A peptide dataset for target analysis of human complement system proteins [PDF]
Data in BriefThe targeted LC-MS/MS method has been widely applied for peptide quantification, offering sensibility, specificity, and reproducibility to the analysis. However, it requires the prior selection of targets, including the construction of a spectral library.
Thais Cristina Tirado +4 more
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Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion
Frontiers in Microbiology, 2016 The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh +4 more
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Complement System Proteins in the Human Aqueous Humor and Their Association with Primary Open-Angle Glaucoma [PDF]
Journal of Personalized Medicine, 2023 This study discovers the complement protein profile in the aqueous humor (AH) of human subjects and investigates its association with primary open-angle glaucoma (POAG) pathogenesis.
Jeremy Altman +2 more
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A new perspective on the pathophysiology of kidney diseases: the intracellular complement system- “complosome” [PDF]
Frontiers in NephrologyThe complement cascade is a vital component of the innate immune system. It consists of around 50 proteins, including circulating complement proteins and membrane-bound receptors. It operates through three main activation pathways: classical, lectin, and
Emre Leventoğlu, Sevcan A. Bakkaloğlu
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Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D [PDF]
Communications BiologyRecent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D).
Xiaowei Hu +10 more
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Plasmid-encoded toxin of Escherichia coli cleaves complement system proteins and inhibits complement-mediated lysis in vitro [PDF]
Frontiers in Cellular and Infection MicrobiologyPlasmid-encoded toxin (Pet) is an autotransporter protein of the serine protease autotransporters of Enterobacteriaceae (SPATE) family, important in the pathogenicity of Escherichia coli. The pet gene was initially found in the enteroaggregative E. coli (
Gabriel B. Correa +7 more
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Low serum complement level is associated with higher mortality in tuberculous meningitis: a retrospective cohort study [PDF]
Encephalitis, 2023 Purpose We evaluated the associations between serum complement levels and tuberculous meningitis (TBM), bacterial meningitis (BM), and viral meningitis (VM), as well as the association between serum complement levels and mortality in TBM.
Hansol Im +7 more
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Comprehensive review of membranoproliferative glomerulonephritis: spotlighting the latest advances in revised classification and treatment [PDF]
Childhood Kidney Diseases, 2023 Membranoproliferative glomerulonephritis (MPGN) is a complex group of renal diseases characterized by a specific pattern of glomerular injury that includes thickening of the capillary wall and mesangial expansion, leading to a heterogeneous group of ...
Jeong Yeon Kim
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The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
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Dysregulation of complement system in neuropsychiatric disorders: A mini review
Biomarkers in Neuropsychiatry, 2022 Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation
Danny Perez Sierra +2 more
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