Complementing antibody profiles: Assessing antibody function on antigen microarrays [PDF]
, 2012 Antibody effector functions other than neutralization depend on interactions with soluble and cellular components of the immune system. Antigen recognition is usually oligoclonal, with the different clones of antibodies belonging to different ...
Papp, Krisztián +2 more
core +1 more source
Factor H Family Proteins in Complement Evasion of Microorganisms
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
doaj +1 more source
TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement [PDF]
, 2014 Immune molecules, including complement proteins C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement localizes to synapses and refines the developing visual system via C3-dependent microglial phagocytosis of ...
Bialas, Allison R., Stevens, Beth
core +1 more source
Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion
Frontiers in Microbiology, 2016 The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh +4 more
doaj +1 more source
Role of the complement system in the tumor microenvironment
Cancer Cell International, 2019 The complement system has traditionally been considered a component of innate immunity against invading pathogens and “nonself” cells. Recent studies have demonstrated the immunoregulatory functions of complement activation in the tumor microenvironment (
Ronghua Zhang +4 more
doaj +1 more source
F1000Research, 2020 The complement system consists of more than 30 plasma as well as cell surface proteins that together constitute a major arm of the immune system. The long-held belief is that most of the complement components are synthesized by hepatocytes in the liver ...
Berhane Ghebrehiwet
doaj +1 more source
Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hammerschmidt, Claudia +6 more
core +3 more sources
Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]
, 2018 Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean +11 more
core +2 more sources
The Kaposi's Sarcoma-associated Herpesvirus Complement Control Protein Mimics Human Molecular Mechanisms for Inhibition of the Complement System [PDF]
Journal of Biological Chemistry, 2004 Kaposi's sarcoma-associated human herpesvirus (KSHV) is thought to cause Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Previously, we reported that the KSHV complement control protein (KCP) encoded within the viral genome is a potent regulator of the complement system; it acts both as a cofactor for factor I and ...
Linda, Mark +6 more
openaire +2 more sources
Precision Medicine in Neurology: The Inspirational Paradigm of Complement Therapeutics
Pharmaceuticals, 2020 Precision medicine has emerged as a central element of healthcare science. Complement, a component of innate immunity known for centuries, has been implicated in the pathophysiology of numerous incurable neurological diseases, emerging as a potential ...
Maria Gavriilaki +2 more
doaj +1 more source