Results 51 to 60 of about 327,401 (305)
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Rocha-Ferreira, E +5 more
core +1 more source
The Role of Apoptosis Proteins and Complement Components in the Etiopathogenesis of Systemic Lupus Erythematosus [PDF]
Clinics, 2010 Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the ...
Liphaus, Bernadete L. +1 more
openaire +5 more sources
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings [PDF]
, 2011 Characterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or ...
Maciejewski, Mateusz +5 more
core +1 more source
Complement in neurological disorders and emerging complement-targeted therapeutics. [PDF]
, 2020 The complement system consists of a network of plasma and membrane proteins that modulate tissue homeostasis and contribute to immune surveillance by interacting with the innate and adaptive immune systems.
Peter J. Spaeth +5 more
core +1 more source
Bio-Protocol, 2021 The complement system is a central component of innate immunity, responsible for recognition and killing of bacteria by tagging invaders through opsonisation, thereby promoting phagocytosis, and by direct lysis.
Wioleta Zelek
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Ancient origins: complement in invertebrates [PDF]
Invertebrate Survival Journal, 2005 Proteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom.In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that arehomologues of C3, the central component of the ...
SV Nair, A Ramsden, DA Raftos
doaj +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Rat C‐reactive protein activates the autologous complement system
Immunology, 2003 SummaryActivation of complement is a biological function of human C‐reactive protein (hCRP), whereas rat CRP (rCRP) has been claimed to be unable to activate complement. As important biological functions of proteins are probably conserved among species, we re‐evaluated, using various ligands, the capability of rCRP to activate complement.
Niubel, Diaz Padilla +6 more
openaire +3 more sources
Expression and localization of proteins of the complement system in human skin. [PDF]
Journal of Clinical Investigation, 1992 The complement system participates in the immune recognition of foreign antigens, many of which may penetrate the skin by physical injury or transcutaneous adsorption. In this study, we examined the presence of complement components and complement regulatory proteins in the human skin and cultured human keratinocytes.
N, Dovezenski, R, Billetta, I, Gigli
openaire +2 more sources