Results 51 to 60 of about 325,997 (305)

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Ancient origins: complement in invertebrates [PDF]

Invertebrate Survival Journal, 2005
Proteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom.In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that arehomologues of C3, the central component of the ...
SV Nair, A Ramsden, DA Raftos
doaj   +2 more sources

Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens

Frontiers in Physics, 2021
The complement system is assembled from a network of proteins that function to bring about the first line of defense of the body against invading pathogens.
Nehemiah T. Zewde, Rohaine V. Hsu, Dimitrios Morikis, Giulia Palermo, Giulia Palermo   +4 more
doaj   +1 more source

Rat C‐reactive protein activates the autologous complement system

Immunology, 2003
SummaryActivation of complement is a biological function of human C‐reactive protein (hCRP), whereas rat CRP (rCRP) has been claimed to be unable to activate complement. As important biological functions of proteins are probably conserved among species, we re‐evaluated, using various ligands, the capability of rCRP to activate complement.
Niubel, Diaz Padilla, Wim K, Bleeker, Yvonne, Lubbers, Gemma M M, Rigter, Gerard J, Van Mierlo, Mohamed R, Daha, C Erik, Hack   +6 more
openaire   +3 more sources

Expression and localization of proteins of the complement system in human skin. [PDF]

Journal of Clinical Investigation, 1992
The complement system participates in the immune recognition of foreign antigens, many of which may penetrate the skin by physical injury or transcutaneous adsorption. In this study, we examined the presence of complement components and complement regulatory proteins in the human skin and cultured human keratinocytes.
N, Dovezenski, R, Billetta, I, Gigli
openaire   +2 more sources

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott   +26 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

MINI-REVIEW: SYSTEMIC LUPUS ERYTHEMATOSUS AND DEFICIENCIES OF EARLY COMPONENTS OF THE COMPLEMENT CLASSICAL PATHWAY

Frontiers in Immunology, 2016
The complement system plays an important role in the innate and acquired immune response against pathogens. It consists of more than 30 proteins found in soluble form or attached to cell membranes. Most complement proteins circulate in inactive forms and
Lourdes eIsaac, Ana Catarina Lunz Macedo
doaj   +1 more source

On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. [PDF]

PLoS Neglected Tropical Diseases, 2013
It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the
Leonardo P Farias, Greice Krautz-Peterson, Cibele A Tararam, Bogar O Araujo-Montoya, Tatiana R Fraga, Henrique K Rofatto, Floriano P Silva, Lourdes Isaac, Akram A Da'dara, R Alan Wilson, Charles B Shoemaker, Luciana C C Leite   +11 more
doaj   +1 more source