Results 1 to 10 of about 2,937,320 (249)
Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion [PDF]
Frontiers in Microbiology, 2016 The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh +4 more
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Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli
Current Issues in Molecular Biology, 2021 In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ...
Maria G. Detsika, Elias A. Lianos
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Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. [PDF]
PLoS Medicine, 2011 Pregnancy in women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab)--autoimmune conditions characterized by complement-mediated injury--is associated with increased risk of preeclampsia and miscarriage. Our previous studies
Jane E Salmon +9 more
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Effect of Heme Oxygenase-1 Depletion on Complement Regulatory Proteins Expression in the Rat
Antioxidants, 2022 Heme oxygenase has been implicated in the regulation of various immune responses including complement activation. Using a transgenic rat model of HO-1 depletion, the present study assessed the effect of HO-1 absence on the expression of complement ...
Maria G. Detsika +4 more
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Upregulation of complement proteins in lung cancer cells mediates tumor progression
Frontiers in Oncology, 2023 IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko +16 more
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The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
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Frontiers in Immunology, 2023 Background and aimsComplement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis.Materials and ...
Huan Tang +20 more
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Genetic engineering strategies to prevent the effects of antibody and complement on xenogeneic chondrocytes [PDF]
European Cells & Materials, 2015 Advances in animal transgenesis may allow using xenogeneic chondrocytes in tissue-engineering applications for clinical cartilage repair. Porcine cartilage is rejected by humoral and cellular mechanisms that could be overcome by identifying key molecules
R Sommaggio +5 more
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Frontiers in Pharmacology, 2022 Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases.
Loveleena Bansal +8 more
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Laboratory tests for disorders of complement and complement regulatory proteins [PDF]
American Journal of Hematology, 2015 The complement pathway is a cascade of proteases that is involved in immune surveillance and innate immunity, as well as adaptive immunity. Dysfunction of the complement cascade may be mediated by aberrations in the pathways of activation, complement regulatory proteins, or complement deficiencies, and has been linked to a number of hematologic ...
Angela R, Shih, Mandakolathur R, Murali
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