Results 1 to 10 of about 305,759 (329)

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion [PDF]

Frontiers in Microbiology, 2016
The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and ...
Elise Sofie Hovingh, Elise Sofie Hovingh, Bryan van den Broek, Ilse Jongerius, Ilse Jongerius   +4 more
doaj   +7 more sources

Complement proteins and complement regulatory proteins are associated with age-related macular degeneration stage and treatment response [PDF]

Journal of Neuroinflammation
Background Dysregulation of the complement system is involved in development of age-related macular degeneration (AMD). The complement cascade is regulated by membrane bound complement regulatory proteins (Cregs) on mononuclear leukocytes among others ...
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen   +7 more
doaj   +3 more sources

Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli [PDF]

Current Issues in Molecular Biology, 2021
In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ...
Maria G. Detsika, Elias A. Lianos
doaj   +6 more sources

Complement and complement regulatory proteins are upregulated in lungs of COVID-19 patients [PDF]

Pathology - Research and Practice, 2023
We explored the pathological changes and the activation of local complement system in COVID-19 pneumonia. Lung paraffin sections of COVID-19 infected patients were analyzed by HE (hematoxylin-eosin) staining. The deposition of complement C3, the deposition of C3b/iC3b/C3d and C5b-9, and the expression of complement regulatory proteins, CD59, CD46 and ...
Xiaowen Ge, Zhui Yu, Xinxin Guo, Ling Li, Ling Ye, Maosong Ye, Jingping Yuan, Chouwen Zhu, Weiguo Hu, Yingyong Hou   +9 more
europepmc   +4 more sources

Expression levels of complement regulatory proteins (CD35, CD55 and CD59) on peripheral blood cells of patients with chronic kidney disease [PDF]

International Journal of General Medicine, 2019
Dalia Mahmoud Eldewi,1 Alshaymaa M Alhabibi,1 Hanaa Mohammed Eid El Sayed,2 Sammar Ahmed Kasim Mahmoud,2 Sanaa Mohammed El Sadek,3 Rasha Mahmoud Gouda,3 Mohammed Abd El Malik Hassan,4 Amal H Ibrahim,2 Naglaa F Abd El Haliem5 1Clinical Pathology ...
Eldewi DM, Alhabibi AM, El Sayed HME, Mahmoud SAK, El Sadek SM, Gouda RM, Hassan MAEM, Ibrahim AH, Abd El Haliem NF   +8 more
doaj   +3 more sources

Effect of Heme Oxygenase-1 Depletion on Complement Regulatory Proteins Expression in the Rat [PDF]

Antioxidants, 2022
Heme oxygenase has been implicated in the regulation of various immune responses including complement activation. Using a transgenic rat model of HO-1 depletion, the present study assessed the effect of HO-1 absence on the expression of complement ...
Maria G. Detsika, Eirini Theochari, Kostas Palamaris, Harikleia Gakiopoulou, Elias A. Lianos   +4 more
doaj   +2 more sources

Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion [PDF]

Frontiers in Immunology, 2023
Background and aimsComplement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis.Materials and ...
Huan Tang, Huan Tang, Xinyue Hu, Xinyue Hu, Li Li, Shuanglinzi Deng, Shuanglinzi Deng, Yuanyuan Jiang, Yuanyuan Jiang, Lisha Luo, Lisha Luo, Runjin Cai, Runjin Cai, Yifei Yang, Yifei Yang, Chendong Wu, Chendong Wu, Xiaoxiao Gong, Xiaoxiao Gong, Juntao Feng, Juntao Feng   +20 more
doaj   +2 more sources

Complement regulatory proteins in glomerular diseases [PDF]

Kidney International, 1998
Complement activation plays a critical role in the pathogenesis of many forms of glomerulonephritis. Complement activation leads to tissue injury through various mechanisms including the generation of chemotactic factors and activation of the resident glomerular cells following C5b-9 insertion.
Masaomi Nangaku
openalex   +3 more sources

The effect of splenectomy on complement regulatory proteins in erythrocytes in β-thalassemia major [PDF]

Archives of Medical Science, 2018
Introduction Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major (β-TM) patients. The role of complement system in the etiopathogenesis of hemolysis observed in β-TM were released.
Ayşegül Uğur Kurtoğllu, Belkıs Koçtekin, Erdal Kurtoğlu, Mustafa Yildiz   +3 more
doaj   +2 more sources

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection [PDF]

Malaria Journal, 2019
Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on RBCs are an ...
Damian A. Oyong, Jessica R. Loughland, Arya SheelaNair, Dean Andrew, Fabian D. L. Rivera, Kim A. Piera, Timothy William, Matthew J. Grigg, Bridget E. Barber, Ashraful Haque, Christian R. Engwerda, James S. McCarthy, Nicholas M. Anstey, Michelle J. Boyle   +13 more
doaj   +2 more sources