Results 21 to 30 of about 173,706 (280)
Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration [PDF]
Immunity & AgeingBackground Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a progressive degenerative disease leading to irreversible vision loss in elderly individuals.
Jenni Martinez Villarruel Hinnerskov +7 more
doaj +2 more sources
Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia
Platelets, 2017 In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger +3 more
doaj +2 more sources
Review: Complement and its regulatory proteins in kidney diseases [PDF]
Nephrology, 2010 ABSTRACTComplement is a part of the body's innate immune system that helps defend the host from microbial infection. It is tightly controlled by a number of cell surface and fluid‐phase proteins so that under normal circumstances injury to autologous tissues is avoided.
Allison M, Lesher, Wen-Chao, Song
exaly +3 more sources
Localization of the complement regulatory proteins in the normal human kidney
Kidney International, 1994 The kidney is an organ where complement-mediated tissue injuries take place by various stimuli. To assess how the kidney is protected from the autologous complement attack, comparative localization of decay accelerating factor (DAF), membrane cofactor protein (MCP) and 20 kDa homologous restriction factor (HRF20) was studied in the normal human kidney.
Ichida, Shizunori +4 more
openaire +3 more sources
Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus.
Folia Histochemica et Cytobiologica, 2007 CD59 is one of the key molecules involved in cell protection against autologus complement. The fact that complement regulatory proteins are able to prevent hyperacute rejection of organs in pig to primate model, raises the question of possible complement
Agnieszka Kinsner +6 more
doaj +3 more sources
The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host’s Complement System
Biomolecules, 2022 The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites.
Sajad Rashidi +5 more
doaj +1 more source
Genetic engineering strategies to prevent the effects of antibody and complement on xenogeneic chondrocytes [PDF]
European Cells & Materials, 2015 Advances in animal transgenesis may allow using xenogeneic chondrocytes in tissue-engineering applications for clinical cartilage repair. Porcine cartilage is rejected by humoral and cellular mechanisms that could be overcome by identifying key molecules
R Sommaggio +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases.
Loveleena Bansal +8 more
doaj +1 more source
Laboratory tests for disorders of complement and complement regulatory proteins [PDF]
American Journal of Hematology, 2015 The complement pathway is a cascade of proteases that is involved in immune surveillance and innate immunity, as well as adaptive immunity. Dysfunction of the complement cascade may be mediated by aberrations in the pathways of activation, complement regulatory proteins, or complement deficiencies, and has been linked to a number of hematologic ...
Angela R, Shih, Mandakolathur R, Murali
openaire +2 more sources
Frontiers in Immunology, 2022 Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement.
Kelly C. Fahnoe +11 more
doaj +1 more source