Results 1 to 10 of about 169,959 (149)

CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever

mBio, 2022
Relapsing fever, caused by diverse Borrelia spirochetes, is prevalent in many parts of the world and causes significant morbidity and mortality. To investigate the pathoetiology of relapsing fever, we performed a high-throughput screen of Borrelia ...
Gunjan Arora, Geoffrey E. Lynn, Xiaotian Tang, Connor E. Rosen, Dieuwertje Hoornstra, Andaleeb Sajid, Joppe W. Hovius, Noah W. Palm, Aaron M. Ring, Erol Fikrig   +9 more
doaj   +2 more sources

Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells [PDF]

eLife
Tendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging.
Hiroki Tsutsumi, Tomoki Chiba, Yuta Fujii, Takahide Matsushima, Tsuyoshi Kimura, Akinori Kanai, Akio Kishida, Yutaka Suzuki, Hiroshi Asahara   +8 more
doaj   +2 more sources

CD55 may be a new target for colorectal cancer treatment [PDF]

Scientific Reports
In the early stage, our research group injected lentivirus carrying blood type A antigen into tumors as a drug, and the tumor volume of mice was significantly reduced. We speculate that the complement system plays an important role in anti-tumor therapy,
Qiong Luo, Yingjia Mao, Rong Yu, Fuqian Zhao, Hongmei Niu, Daofu Shen, Huan Tian, Lei Wang   +7 more
doaj   +2 more sources

Drug Resistance in Multiple Myeloma: Tumor-Intrinsic Mechanisms and the Bone Marrow Microenvironment. [PDF]

Cell Biochem Funct
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder, and despite substantial improvements in prognosis achieved through chemotherapy, immunotherapy, and autologous stem cell transplantation, most patients ultimately develop relapsed or refractory disease. Drug resistance (DR) is increasingly recognized as a dynamically evolving ecosystem
Chen Y, Huang W, Tang M, Wang X.
europepmc   +2 more sources

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection? [PDF]

Eur J Immunol
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Bettoni S, Qviberg E, Chaloner E, Lavender H, Laabei M.   +4 more
europepmc   +2 more sources

Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue [PDF]

Arthritis & Rheumatism, 1999
Fibroblast-like synoviocytes (FLS) express decay-accelerating factor (CD55) at high levels. Recently, it was found that CD55 is a specific cellular ligand for the 7-span transmembrane receptor CD97. The objective of this study was to define the expression of this receptor-ligand pair in synovial tissue (ST) to provide more insight into the interaction ...
Hamann, J. [=Jörg], Wishaupt, J. O., van Lier, R. A., Smeets, T. J., Breedveld, F. C., Tak, P. P.   +5 more
openaire   +3 more sources

Antigen‐presenting cell exosomes are protected from complement‐mediated lysis by expression of CD55 and CD59 [PDF]

European Journal of Immunology, 2003
AbstractExosomes are secreted nanometer‐sized vesicles derived from antigen‐presenting cells, which have attracted recent interest as they likely play important roles in immune regulation, and their use as cell‐free tools for immunotherapy has been proposed.
Aled, Clayton, Claire L, Harris, Jacquelyn, Court, Malcolm D, Mason, B Paul, Morgan   +4 more
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model

Scientific Reports, 2022
Pig-to-human organ transplantation is a feasible solution to resolve the shortage of organ donors for patients that wait for transplantation. To overcome immunological rejection, which is the main hurdle in pig-to-human xenotransplantation, various ...
Nayoung Ko, Joohyun Shim, Hyoung-Joo Kim, Yongjin Lee, Jae-Kyung Park, Kyungmin Kwak, Jeong-Woong Lee, Dong-Il Jin, Hyunil Kim, Kimyung Choi   +9 more
doaj   +1 more source

Cromer-related blood group antigens and the glycosyl phosphatidylinositol-linked protein, decay-accelerating factor DAF (CD55) [PDF]

Immunohematology, 1990
Abstract Cromer-related blood group antigens are located on the complement regulatory glycoprotein, decay-accelerating factor (DAF). DAF is not detectable on red cells from individuals with a Cromer null phenotype (termed Inab), which is probably an inherited condition.
openaire   +2 more sources