KLF4 and CD55 expression and function depend on each other
Frontiers in ImmunologyThe transcription factor Kruppel-like factor 4 (KLF4) regulates the expression of immunosuppressive and anti-thrombotic proteins. Despite its importance in maintaining homeostasis, the signals that control its expression and the mechanism of its ...
Edward Medof, Michael Strainic
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CD55 is over-expressed in the tumour environment [PDF]
British Journal of Cancer, 2001 CD55 is a protein that protects cells from complement-mediated attack. 791Tgp72 is an antigen which has been used successfully as a target for both tumour imaging and cancer vaccines. 791Tgp72 has recently been identified as CD55. Quantitative expression of CD55 in the tumour environment was therefore studied.
L G Durrant
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Neoplasia, 2006 Decay-accelerating factor (CD55) is a member of membrane-bound complement-regulatory proteins. CD55 expression correlates with poor survival in patients with colorectal cancer and has been implicated in the survival and tumorigenesis of blood-borne ...
Kenneth Pienta +2 more
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Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites
eLife, 2021 Invasion of human erythrocytes by the malaria parasite Plasmodium falciparum is a multi-step process. Previously, a forward genetic screen for P. falciparum host factors identified erythrocyte CD55 as essential for invasion, but its specific role and how
Bikash Shakya +3 more
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CD55 may be an important prognostic factor of thymic epithelial tumors: a retrospective study [PDF]
World Journal of Surgical OncologyBackground Thymic epithelial tumors (TETs) currently lack effective prognostic factors and novel treatment approaches, the aim of the study is to investigate the expression of CD55 in TETs and the relationship with clinicopathological characteristics and
Jiao Ma +11 more
doaj +2 more sources
Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells [PDF]
eLifeTendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging.
Hiroki Tsutsumi +8 more
doaj +2 more sources
GDPD5-CD55-EGFR competitive binding axis regulates radioresistance and lipid accumulation in rectal cancer [PDF]
Cell Death and DiseaseResistance to neoadjuvant chemoradiotherapy in rectal cancer diminishes survival benefits, potentially due to dysregulated lipid metabolism, though the mechanisms are unclear.
Ruiqiu Zhu +7 more
doaj +2 more sources
The Function of Transforming Growth Factor 2 in Facilitating Inflammasome Activation to Enhance the Development of Myopia via Complement System [PDF]
CellsMyopia is one of the major public health conditions with significant complications. This study investigates the role of transforming growth factor (TGF)-β2, complement activation, and inflammasome pathways in myopia progression using a Brown Norway rat ...
Sheng-Chun Lin +11 more
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Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM. [PDF]
Ann Clin Transl NeurolABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Sala-Coromina J +11 more
europepmc +2 more sources
CD55 may be a new target for colorectal cancer treatment
Scientific ReportsIn the early stage, our research group injected lentivirus carrying blood type A antigen into tumors as a drug, and the tumor volume of mice was significantly reduced. We speculate that the complement system plays an important role in anti-tumor therapy,
Qiong Luo +7 more
doaj +3 more sources