Results 21 to 30 of about 10,623 (204)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Effective clearance of rituximab-resistant tumor cells by breaking the mirror-symmetry of immunoglobulin G and simultaneous binding to CD55 and CD20

Scientific Reports, 2023
Complement-dependent cytotoxicity (CDC), which eliminates aberrant target cells through the assembly and complex formation of serum complement molecules, is one of the major effector functions of anticancer therapeutic antibodies.
Sang Min Lee, Sung-Won Min, Hyeong Sun Kwon, Gong-Deuk Bae, Ji Hae Jung, Hye In Park, Seung Hyeon Lee, Chung Su Lim, Byoung Joon Ko, Ji Chul Lee, Sang Taek Jung   +10 more
doaj   +1 more source

CD39+CD55− Fb Subset Exhibits Myofibroblast-Like Phenotype and Is Associated with Pain in Osteoarthritis of the Knee

Biomedicines, 2023
Recent studies utilizing single-cell analysis have unveiled the presence of various fibroblast (Fb) subsets within the synovium under inflammatory conditions in osteoarthritis (OA), distinguishing them from those in rheumatoid arthritis (RA).
Maho Tsuchiya, Yoshihisa Ohashi, Yoshio Kodera, Masashi Satoh, Takashi Matsui, Kensuke Fukushima, Dai Iwase, Jun Aikawa, Manabu Mukai, Gen Inoue, Masashi Takaso, Kentaro Uchida   +11 more
doaj   +1 more source

Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare type of acquired Haemolytic anaemia that is described as a triad of acquired intravascular Haemolysis, venous thrombosis and anaemia with pancytopenia sometimes due to bone marrow failure. However the
Archana Dambal, Naren V Nimbal, Shanmukh T Kalsad, K Pramod, M P Madhavaranga   +4 more
doaj   +1 more source

Function of complement regulatory proteins in immunity of reproduction: a review

Czech Journal of Animal Science, 2005
Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová, M. Simon, J. Antalíková   +2 more
doaj   +1 more source

Alteration of membrane complement regulators is associated with transporter status in patients on peritoneal dialysis. [PDF]

PLoS ONE, 2017
INTRODUCTION:A growing body of evidence from animal models and cell culture studies indicate an important role of a local regulatory complement system (CS) in peritoneal injury during peritoneal dialysis (PD).
Daniel Kitterer, Dagmar Biegger, Stephan Segerer, Niko Braun, M Dominik Alscher, Joerg Latus   +5 more
doaj   +1 more source

1,25-Dihydroxyvitamin D3 promotes a sustained LPS-induced NF-κB-dependent expression of CD55 in human monocytic THP-1 cells. [PDF]

PLoS ONE, 2012
The vitamin D3 system imposes immunosuppressive effects on monocytic cells, in part, by inhibiting NF-κB-dependent expression of proinflammatory mediators.
Michael G Izban, Bogdan J Nowicki, Stella Nowicki   +2 more
doaj   +1 more source

Functional Dissection of the Dominant Role of CD55 in Protecting Vesicular Stomatitis Virus against Complement-Mediated Neutralization

Viruses, 2021
The human complement system is an important part of the innate immune system. Its effector pathways largely mediate virus neutralization. Vesicular stomatitis virus (VSV) activates the classical pathway of the complement, leading to virus neutralization ...
Nisha Asok Kumar, Sreenath Muraleedharan Suma, Umerali Kunnakkadan, Joydeep Nag, Reshma Koolaparambil Mukesh, Douglas S. Lyles, John Bernet Johnson   +6 more
doaj   +1 more source

Constitutive HO-1 and CD55 (DAF) Expression and Regulatory Interaction in Cultured Podocytes

Biomedicines, 2023
Overexpression of the inducible heme oxygenase (HO-1) isoform in visceral renal glomerular epithelial cells (podocytes) using in vivo transgenesis methods was shown to increase glomerular expression of the complement regulatory protein decay-accelerating
Elias A. Lianos, Kelsey Wilson, Katerina Goudevenou, Maria G. Detsika, Mukut Sharma   +4 more
doaj   +1 more source

Mitochondrial injury and complement dysregulation are drivers of pathological inflammation in viral myocarditis

Journal of Virology
Enteroviruses cause nearly 1 billion global infections annually and are associated with a diverse array of human illnesses. Among these, myocarditis and the resulting chronic inflammation have been recognized as major contributing factors to virus ...
Yasir Mohamud, Amirhossein Bahreyni, Sinwoo Wendy Hwang, Jingfei Carly Lin, Zhihan Claire Wang, Jingchun Zhang, Honglin Luo   +6 more
doaj   +1 more source