Results 1 to 10 of about 9,613 (181)
Advances in cryo-EM that have shaped mechanistic models of membrane-attack-complex assembly and regulation [PDF]
IUCrJThe complement system is a blood-based immune network that plays a crucial role in fighting infection and maintaining immune homeostasis. The membrane attack complex (MAC) is a pore assembled from complement proteins that creates holes in cells when the ...
Dylan P. Noone, Doryen Bubeck
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Role of NK cells in immune escape in patients with classical paroxysmal nocturnal haemoglobinuria [PDF]
Clinical and Translational MedicineBackground Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal haematopoietic stem cell disorder. Immune escape is crucial in PNH, and our previous studies revealed that natural killer (NK) cells potential participate in the immune escape of
Chaomeng Wang +10 more
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The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus
Cell Reports, 2023 Summary: Complement-dependent microglia pruning of excitatory synapses has been widely reported in physiological and pathological conditions, with few reports concerning pruning of inhibitory synapses or direct regulation of synaptic transmission by ...
Zuolong Chen, Yong Shen, Xiaoli Yang
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Altered expression of complement regulatory proteins CD35 and CD59 in acute lymphoblastic and acute myeloblastic leukemia suggests a context-based pattern [PDF]
Discover OncologyThe complement system is a vital part of the innate immune defense, playing a key role in clearing immune complexes; however, its activity must be carefully regulated to avoid damage to healthy cells.
Reem Hossam EL-Din Ahmed +3 more
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Determination of the Membrane Environment of CD59 in Living Cells [PDF]
Biomolecules, 2018 The organization and dynamics of proteins and lipids in the plasma membrane, and their role in membrane functionality, have been subject of a long-lasting debate.
Gergő Fülöp +4 more
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Indonesian Journal of Pharmacy, 2021 Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole), an alkaloid isolated from plants Ochrosia elliptica, showed anticancer activity. A previous study demonstrated that ellipticine exhibited a reduction of the proliferation and self-renewal ability of ...
Adam Hermawan, Herwandhani Putri
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Dynamics and Molecular Interactions of GPI-Anchored CD59
Toxins, 2023 CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the complement membrane attack complex (MAC), an immune pore that can damage human cells. While CD59 blocks
Tomas B. Voisin +3 more
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Frontiers in Oncology, 2021 BackgroundDrug resistance remains a serious challenge to rituximab therapy in B-NHL (B cell non-Hodgkin’s lymphoma). CDC (complement-dependent cytotoxicity) has been proposed as a major antitumor mechanism of rituximab, and direct abrogation of CD59 ...
Xiaowen Ge +15 more
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A Splice Site Mutation Associated with Congenital CD59 Deficiency
Hematology Reports, 2022 Congenital CD59 deficiency is a recently described rare autosomal recessive disease associated with CD59 gene mutations that lead to deficient or dysfunctional CD59 protein on the cell surface.
Jiani N. Chai +4 more
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CD59 (CD59 molecule, complement regulatory protein) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on CD59 (CD59 molecule, complement regulatory protein), with data on DNA, on the protein encoded, and where the gene is implicated.
Donev, RM, Kolev, MV
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