Results 1 to 10 of about 13,567 (213)

The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus

Cell Reports, 2023
Summary: Complement-dependent microglia pruning of excitatory synapses has been widely reported in physiological and pathological conditions, with few reports concerning pruning of inhibitory synapses or direct regulation of synaptic transmission by ...
Xiaoli Yang, Zuolong Chen, Yong Shen
exaly   +4 more sources

Advances in cryo-EM that have shaped mechanistic models of membrane-attack-complex assembly and regulation [PDF]

IUCrJ
The complement system is a blood-based immune network that plays a crucial role in fighting infection and maintaining immune homeostasis. The membrane attack complex (MAC) is a pore assembled from complement proteins that creates holes in cells when the ...
Dylan P. Noone, Doryen Bubeck
doaj   +2 more sources

Role of NK cells in immune escape in patients with classical paroxysmal nocturnal haemoglobinuria [PDF]

Clinical and Translational Medicine
Background Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal haematopoietic stem cell disorder. Immune escape is crucial in PNH, and our previous studies revealed that natural killer (NK) cells potential participate in the immune escape of
Chaomeng Wang, Yan Yang, Wei Wang, Liyan Li, Mengting Che, Yingying Chen, Honglei Wang, Zhaoyun Liu, Lijuan Li, Hui Liu, Rong Fu   +10 more
doaj   +2 more sources

Dynamics and Molecular Interactions of GPI-Anchored CD59

Toxins, 2023
CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the complement membrane attack complex (MAC), an immune pore that can damage human cells. While CD59 blocks
Tomas B. Voisin, Emma C. Couves, Edward W. Tate, Doryen Bubeck   +3 more
doaj   +4 more sources

Altered expression of complement regulatory proteins CD35 and CD59 in acute lymphoblastic and acute myeloblastic leukemia suggests a context-based pattern [PDF]

Discover Oncology
The complement system is a vital part of the innate immune defense, playing a key role in clearing immune complexes; however, its activity must be carefully regulated to avoid damage to healthy cells.
Reem Hossam EL-Din Ahmed, Menatalla Mostafa Mahmoud, Mohamed Ahmed El-Azizi, Noha Samir Farag   +3 more
doaj   +2 more sources

Integrative Bioinformatics Analysis Reveals Possible Target and Mechanism of Ellipticine Against Breast Cancer Stem Cells.

Indonesian Journal of Pharmacy, 2021
Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole), an alkaloid isolated from plants Ochrosia elliptica, showed anticancer activity. A previous study demonstrated that ellipticine exhibited a reduction of the proliferation and self-renewal ability of ...
Adam Hermawan, Herwandhani Putri
doaj   +1 more source

Herbal NF-κB Inhibitors Sensitize Rituximab-Resistant B Lymphoma Cells to Complement-Mediated Cytolysis

Frontiers in Oncology, 2021
BackgroundDrug resistance remains a serious challenge to rituximab therapy in B-NHL (B cell non-Hodgkin’s lymphoma). CDC (complement-dependent cytotoxicity) has been proposed as a major antitumor mechanism of rituximab, and direct abrogation of CD59 ...
Xiaowen Ge, Yiqun Du, Yiqun Du, Jianfeng Chen, Na Zhu, Jiamei Yao, Xin Zhang, Xin Zhang, Na Wang, Na Wang, Yujing Sun, Yujing Sun, Feng Gao, Weiguo Hu, Weiguo Hu, Yingyong Hou   +15 more
doaj   +1 more source

A Splice Site Mutation Associated with Congenital CD59 Deficiency

Hematology Reports, 2022
Congenital CD59 deficiency is a recently described rare autosomal recessive disease associated with CD59 gene mutations that lead to deficient or dysfunctional CD59 protein on the cell surface.
Jiani N. Chai, Abul Kalam Azad, Kevin Kuan, Xiaoling Guo, Yanhua Wang   +4 more
doaj   +1 more source

Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells. [PDF]

PLoS ONE, 2014
The glycosylphosphatidylinositol (GPI)-anchored molecule CD59 has been implicated in the modulation of T cell responses, but the underlying molecular mechanism of CD59 influencing T cell signaling remained unclear.
Anna M Lipp, Kata Juhasz, Christian Paar, Christoph Ogris, Paul Eckerstorfer, Roland Thuenauer, Jan Hesse, Benedikt Nimmervoll, Hannes Stockinger, Gerhard J Schütz, Ulrich Bodenhofer, Zsolt Balogi, Alois Sonnleitner   +12 more
doaj   +1 more source

Optic neuritis in CD59 deficiency: an extremely rare presentation

The Turkish Journal of Pediatrics, 2022
Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency.
Çağatay Günay, Elvan Yardım, Elif Yaşar, Ayse Semra Hız-Kurul, Gamze Sarıkaya Uzan, Taylan Öztürk, Aylin Yaman, Uluç Yiş   +7 more
doaj   +1 more source