Identification of CD320, SLC44A1 and TNFRSF13B as potential novel therapeutic targets for CAR T-cell therapy in multiple myeloma [PDF]
Frontiers in MedicineIntroductionMultiple myeloma (MM) remains incurable despite effective therapies, with most patients eventually relapsing. Chimeric antigen receptor (CAR) T-cell therapy has improved treatment options but is limited by antigen escape and lack of durable ...
Francesca Garofano +7 more
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Drug Resistance in Multiple Myeloma: Tumor-Intrinsic Mechanisms and the Bone Marrow Microenvironment. [PDF]
Cell Biochem FunctABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder, and despite substantial improvements in prognosis achieved through chemotherapy, immunotherapy, and autologous stem cell transplantation, most patients ultimately develop relapsed or refractory disease. Drug resistance (DR) is increasingly recognized as a dynamically evolving ecosystem
Chen Y, Huang W, Tang M, Wang X.
europepmc +2 more sources
Proteomic Analysis of Endothelial Activation Induced by Adult Angiostrongylus vasorum Homogenate: Insights into Vascular Remodeling and Hemostatic Imbalance [PDF]
AnimalsThe interaction between Angiostrongylus vasorum and the vascular endothelium of the host plays a key role in the pathogenesis of canine angiostrongylosis. The adult stage of A.
Manuel Collado-Cuadrado +9 more
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Immune response and histology of humoral rejection in kidney transplantation
Nefrología (English Edition), 2016 The adaptive immune response forms the basis of allograft rejection. Its weapons are direct cellular cytotoxicity, identified from the beginning of organ transplantation, and/or antibodies, limited to hyperacute rejection by preformed antibodies and not ...
Miguel González-Molina +7 more
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Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil
Revista Brasileira de Hematologia e Hemoterapia, 2011 BACKGROUND: Paroxysmal nocturnal hemoglobinuria is a hematological disease with complex physiopathology. It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best
Lacy Cardoso de Brito Junior +5 more
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Function of complement regulatory proteins in immunity of reproduction: a review
Czech Journal of Animal Science, 2005 Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová +2 more
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Optimizing complement-activating antibody-based cancer immunotherapy: a feasible strategy?
Journal of Translational Medicine, 2004 Passive immunotherapy with monoclonal antibodies (mAb) targeted to specific tumor-associated antigens is amongst the most rapidly expanding approaches to biological therapy of cancer.
Maio Michele +2 more
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Frontiers in Physiology, 2016 Human Gingival Mesenchymal Stem Cells (hGMSC) are multipotential cells that can expand and differentiate in culture under specific and standardized conditions.
Rosaliana Libro +9 more
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The International Journal of Biological Markers, 2013 In colorectal cancer, CD133 + cells from fresh biopsies proved to be more tumorigenic than their CD133 – counterparts. Nevertheless, the function of CD133 protein in tumorigenic cells seems only marginal.
Marica Gemei +3 more
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The HPB-AML-I cell line possesses the properties of mesenchymal stem cells
Journal of Experimental & Clinical Cancer Research, 2010 Background In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML)-M1, HPB-AML-I shows plastic adherence with spindle-like morphology.
Tatsumi Eiji +9 more
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