Results 11 to 20 of about 6,819 (179)
Association of Blood Group Antigen CD59 with Disease [PDF]
Transfusion Medicine and Hemotherapy, 2022 In 2014, the membrane-bound protein CD59 became a blood group antigen. CD59 has been known for decades as an inhibitor of the complement system, located on erythrocytes and on many other cell types. In paroxysmal nocturnal haemoglobinuria (PNH), a stem cell clone with acquired deficiency to express GPI-anchored molecules, including the complement ...
openaire +3 more sources
Six monoclonal antibodies to the CD59 antigen [PDF]
Immunohematology, 1993 Abstract CD59 defines an N -glycosylated glycoprotein expressed on various hemopoietic cells. It is anchored to the cell membrane by a glycosylphosphatidylinositol linkage and restricts the action of homologous complement.
J A, Bryant, A, Fletcher, F F, Yuan
openaire +2 more sources
A new blood group antigen is defined by anti‐
Transfusion, 2014 BackgroundCD59 is a cell surface glycoprotein of approximately 20 kDa limiting the lytic activity of the terminal complement complex C5b‐9. Although CD59 is known as a red blood cell (RBC) antigen defined by monoclonal antibodies, it so far has not been identified as a blood group antigen, since the description of a human alloantibody was missing.
Anliker, Markus +7 more
openaire +2 more sources
Antigen‐presenting cell exosomes are protected from complement‐mediated lysis by expression of CD55 and CD59 [PDF]
European Journal of Immunology, 2003 AbstractExosomes are secreted nanometer‐sized vesicles derived from antigen‐presenting cells, which have attracted recent interest as they likely play important roles in immune regulation, and their use as cell‐free tools for immunotherapy has been proposed.
Aled, Clayton +4 more
openaire +2 more sources
Frontiers in Physiology, 2016 Human Gingival Mesenchymal Stem Cells (hGMSC) are multipotential cells that can expand and differentiate in culture under specific and standardized conditions.
Rosaliana Libro +9 more
doaj +1 more source
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
core +1 more source
Colocalization of the Human CD59 Gene to 11p13 with the MIC11 Cell Surface Antigen
Genomics, 1993 The human CD59 gene encodes a cell surface antigen detected by MEM43 and other antibodies. It has homology to the mouse Ly-6 genes that map on mouse chromosome 15 and are involved in lymphocyte signal transduction. CD59 may play a role in protecting against complement-mediated lysis. The human CD59 gene had been previously localized to 11p13-p14.
W A, Bickmore +4 more
openaire +2 more sources
Expression of the glycosylphosphatidylinositol-linked complement-inhibiting protein CD59 antigen in insect cells using a baculovirus vector [PDF]
Biochemical Journal, 1993 CD59 antigen (CD59) is a glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein which protects human cells from complement-mediated lysis. Here we report the expression of functionally active CD59 in Spodoptera frugiperda insect cells using a baculovirus vector.
A, Davies, B P, Morgan
openaire +2 more sources
The International Journal of Biological Markers, 2013 In colorectal cancer, CD133 + cells from fresh biopsies proved to be more tumorigenic than their CD133 – counterparts. Nevertheless, the function of CD133 protein in tumorigenic cells seems only marginal.
Marica Gemei +3 more
doaj +1 more source
The HPB-AML-I cell line possesses the properties of mesenchymal stem cells
Journal of Experimental & Clinical Cancer Research, 2010 Background In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML)-M1, HPB-AML-I shows plastic adherence with spindle-like morphology.
Tatsumi Eiji +9 more
doaj +1 more source