Results 31 to 40 of about 170,506 (176)

Functional and antigenic similarities between a 94-kD protein of Schistosoma mansoni (SCIP-1) and human CD59. [PDF]

The Journal of experimental medicine, 1994
Schistosomiasis is a parasitic disease affecting approximately 200 million people, primarily in the third world. Schistosoma mansoni, one of the causative agents of this disease, parasitize the human mesenteric and portal blood systems while successfully evading host immune responses.
M, Parizade, R, Arnon, P J, Lachmann, Z, Fishelson   +3 more
openaire   +2 more sources

Molecular pathogenesis of human CD59 deficiency [PDF]

, 2018
Objective To characterize all 4 mutations described for CD59 congenital deficiency. Methods The 4 mutations, p.Cys64Tyr, p.Asp24Val, p.Asp24Valfs*, and p.Ala16Alafs*, were described in 13 individuals with CD59 malfunction.
Mevorach, Dror, Peles, Elior, Schueler-Furman, Ora, Eshed-Eisenbach, Yael, Hila Hoizman, Elior Peles, Dror Mevorach, Hoizman, Hila, Ora Schueler-Furman, B. Paul Morgan, Adi Tabib, Morgan, B. Paul, Karbian, Netanel, Netanel Karbian, Tabib, Adi, Yael Eshed-Eisenbach   +15 more
core   +1 more source

Optic neuritis in CD59 deficiency: an extremely rare presentation [PDF]

, 2022
Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency. In this paper, we report a
Çağatay Günay, Elvan Yardım, Yardim, Elvan, Uzan, Gamze Sarikaya, Gunay, Cagatay, Yaman, Aylin, Uluç Yiş, Taylan Öztürk, YİŞ, ULUÇ, Ayse Semra Hız-Kurul, Ozturk, Taylan, Yasar, Elif, Aylin Yaman, HIZ, AYŞE SEMRA, Gamze Sarıkaya Uzan, Elif Yaşar   +15 more
core   +1 more source

Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. [PDF]

Proceedings of the National Academy of Sciences, 1992
The gene for CD59 [membrane inhibitor of reactive lysis (MIRL), protectin], a phosphatidylinositol-linked surface glycoprotein that regulates the formation of the polymeric C9 complex of complement and that is deficient on the abnormal hematopoietic cells of patients with paroxysmal nocturnal hemoglobinuria, consists of four exons spanning 20 kilobases.
J G, Petranka, D E, Fleenor, K, Sykes, R E, Kaufman, W F, Rosse   +4 more
openaire   +2 more sources

Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. [PDF]

, 2011
Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL).
Graham P. Collins, Liggins, Amanda P., Liggins, AP, Lawrie, Charles H., Banham, Alison H., Pulford, Karen, Pulford Karen, Christopher D. O. Cooper, Cooper Christopher D. O., Christian S. R. Hatton, Hatton, Christian S.R., Cooper, CD, Hatton Christian S. R., Lawrie, CH, Liggins Amanda P., Banham, Alison, Christopher D O Cooper, Hatton, CS, Banham, AH, Collins, GP, Charles H Lawrie, Pulford, K, Amanda P Liggins, Banham Alison H., Karen Pulford, Charles H. Lawrie, Amanda P. Liggins, Collins Graham P., Graham P Collins, Collins, Graham P., Alison H Banham, Christian S R Hatton, Lawrie Charles H., Cooper, Christopher D.O., Alison H. Banham   +34 more
core   +2 more sources

Functionalized Graphene Quantum Dots (GQDs) based Label-Free Optical Fluorescence Sensor for CD59 Antigen Detection and Cellular Bioimaging

Journal of Fluorescence, 2023
Cluster of differentiation (CD59), a cell surface glycoprotein, regulates the complement system to prevent immune damage. In cancer, altered CD59 expression allows tumors to evade immune surveillance, promote growth, and resist certain immunotherapies.
Rahul Shankar, Tade, Ashish, Kalkal, Pravin Onkar, Patil   +2 more
openaire   +4 more sources

The complement-inhibiting protein, Protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells

Clinical and Experimental Immunology, 1991
SUMMARYProtectin (CDS9 antigen) is a 20-kD phosphatidyl-inositol-linked membrane protein that inhibits formation of the membrane attack complex (MAC) of complement on homologous cells. Although the antigen has been identified in a number of human tissues, until recently a functional role had been demonstrated only in circulating cells.
I A, Rooney, A, Davies, D, Griffiths, J D, Williams, M, Davies, S, Meri, P J, Lachmann, B P, Morgan   +7 more
openaire   +3 more sources

Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4 [PDF]

, 2010
Schistosoma haematobium antigen recognition profiles of the human isotypes IgA, IgE, IgG1 and IgG4 were compared by image analysis of western blots. Adult worm antigens separated by 2-dimensional gel electrophoresis were probed with pooled sera from ...
Midzi, N., Maizels, R M, Burchmore, R., Y. HARCUS, Mduluza, T., R. M. MAIZELS, Harcus, Y, Turner, C.M.R., R. BURCHMORE, C. M. TURNER, Mutapi, F, Midzi, N, Mutapi, F., Maizels, R.M., Turner, C M, Maizels, RM, N. MIDZI, Harcus, Y., Bourke, C., F. MUTAPI, T. MDULUZA, Turner, CM, Maizels, R. M., Bourke, C, Turner, C. M., Mduluza, T, Burchmore, R.J.S., Burchmore, R, C. BOURKE   +28 more
core   +1 more source

Contribution of the N-linked carbohydrate of erythrocyte antigen CD59 to its complement-inhibitory activity.

Journal of Biological Chemistry, 1992
The contribution of N-linked carbohydrate to the complement-inhibitory function of the human erythrocyte membrane glycoprotein, CD59, was investigated. Amino acid sequence analysis of tryptic peptides labeled with [3H]borohydride revealed an N-linked carbohydrate moiety at the Asn18 residue.
H, Ninomiya, B H, Stewart, S A, Rollins, J, Zhao, A L, Bothwell, P J, Sims   +5 more
openaire   +2 more sources

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source