Colocalization of the Human CD59 Gene to 11p13 with the MIC11 Cell Surface Antigen
Genomics, 1993 The human CD59 gene encodes a cell surface antigen detected by MEM43 and other antibodies. It has homology to the mouse Ly-6 genes that map on mouse chromosome 15 and are involved in lymphocyte signal transduction. CD59 may play a role in protecting against complement-mediated lysis. The human CD59 gene had been previously localized to 11p13-p14.
W A, Bickmore +4 more
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Expression of the glycosylphosphatidylinositol-linked complement-inhibiting protein CD59 antigen in insect cells using a baculovirus vector [PDF]
Biochemical Journal, 1993 CD59 antigen (CD59) is a glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein which protects human cells from complement-mediated lysis. Here we report the expression of functionally active CD59 in Spodoptera frugiperda insect cells using a baculovirus vector.
A, Davies, B P, Morgan
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SOLUBLE CD59-ANTIGEN LEVELS ARE INCREASED IN RENAL DISEASE PLASMA [PDF]
American Journal of Biochemistry and Biotechnology, 2013 Cluster of Differentiation antigen 59 (CD59) is a g lycosyl phosphatidylinositol-linked protein that pr otects cells from damage by lytic terminal complexes of co mplement. Soluble forms of CD59 in serum have been little investigated in disease states. In the prese nt study, by using a sandwich ELISA, reactivities w ith antibodies to CD59 were compared
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Analysis of PI (phosphatidylinositol)‐anchoring antigens in a patient of paroxysmal nocturnal hemoglobinuria (PNH) reveals deficiency of 1F5 antigen (CD59), a new complement‐regulatory factor [PDF]
FEBS Letters, 1990 FACS analysis together with PIPLC treatment was applied to Pi‐anchoring antigens such as DAF (decay‐accerelating factor, CD55), 1F5 antigen (CD59), CD14 and CD16 on the cell surfaces of blood cells from a normal adult and a male patient with paroxysmal nocturnal hemoglubinuria (PNH).
Taguchi, Ryo +3 more
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Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection. [PDF]
, 2010 Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes.
M. PINDER +7 more
core +1 more source
Stem Cell Research & Therapy, 2018 Background Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesodermal lineages.
Eliana Amati +8 more
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Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes [PDF]
Biochemical Journal, 1992 Several groups have recently described the isolation of a 20 kDa membrane-attack-complex (MAC)-inhibiting protein, termed ‘CD59 antigen’, from human erythrocyte membranes. Antibodies raised against erythrocyte CD59 antigen detect antigen on the surface of many other cell types, and in some of these cells the antigen has been shown to have a molecular ...
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CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy? [PDF]
The Journal of Immunology, 2009 Abstract CD59, a broadly expressed GPI-anchored molecule, regulates formation of the membrane attack complex of the complement cascade. We previously demonstrated that mouse CD59 also down-modulates CD4+ T cell activity in vivo. In this study, we explored the role of CD59 on human CD4+ T cells.
Baalasubramanian, Sivasankar +6 more
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Plasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyte. [PDF]
, 2008 BACKGROUND: The asexual blood stages of the human malaria parasite Plasmodium falciparum produce highly immunogenic polymorphic antigens that are expressed on the surface of the host cell.
Christopher J. Drakeley +26 more
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Frontiers in Immunology, 2019 Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of HLA-II expression and low expression of co-stimulatory molecules such as CD40 and CD80.
Alvaro Avivar-Valderas +14 more
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