Results 11 to 20 of about 13,567 (213)
Association of Blood Group Antigen CD59 with Disease [PDF]
Transfusion Medicine and Hemotherapy, 2022 In 2014, the membrane-bound protein CD59 became a blood group antigen. CD59 has been known for decades as an inhibitor of the complement system, located on erythrocytes and on many other cell types.
C. Weinstock
semanticscholar +4 more sources
Determination of the Membrane Environment of CD59 in Living Cells [PDF]
Biomolecules, 2018 The organization and dynamics of proteins and lipids in the plasma membrane, and their role in membrane functionality, have been subject of a long-lasting debate.
Gergő Fülöp +4 more
doaj +4 more sources
Structural basis for membrane attack complex inhibition by CD59
Nature Communications, 2023 CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins.
Emma C. Couves +6 more
doaj +2 more sources
Cd59 and inflammation regulate Schwann cell development
eLife, 2022 Efficient neurotransmission is essential for organism survival and is enhanced by myelination. However, the genes that regulate myelin and myelinating glial cell development have not been fully characterized.
Ashtyn T Wiltbank +4 more
doaj +2 more sources
Cancer Cell International, 2019 Background T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood.
Yanfei Jia +9 more
doaj +2 more sources
Molecular pathogenesis of human CD59 deficiency [PDF]
Neurology Genetics, 2018 Objective To characterize all 4 mutations described for CD59 congenital deficiency. Methods The 4 mutations, p.Cys64Tyr, p.Asp24Val, p.Asp24Valfs*, and p.Ala16Alafs*, were described in 13 individuals with CD59 malfunction. All 13 presented with recurrent
Netanel Karbian +7 more
semanticscholar +3 more sources
Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59 [PDF]
Multiple Sclerosis Journal, 2019 Background: CD59, a broadly expressed glycosylphosphatidylinositol-anchored protein, is the principal cell inhibitor of complement membrane attack on cells. In the demyelinating disorders, multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), elevated complement protein levels, including ...
W. Zelek +9 more
semanticscholar +5 more sources
Viruses, 2018 The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work has shown that ...
Yujia Li, Griffith D. Parks
doaj +2 more sources
Frontiers in Immunology, 2018 Cellular protection against undesired effects of complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59.
Laura A. Michielsen +7 more
doaj +2 more sources
Acta Neuropathologica Communications, 2017 Pathogenesis in aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorders (herein called NMO) involves complement-dependent cytotoxicity initiated by AQP4-IgG binding to astrocyte AQP4.
Xiaoming Yao, Alan S. Verkman
doaj +2 more sources