Results 11 to 20 of about 9,613 (181)
Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells. [PDF]
PLoS ONE, 2014 The glycosylphosphatidylinositol (GPI)-anchored molecule CD59 has been implicated in the modulation of T cell responses, but the underlying molecular mechanism of CD59 influencing T cell signaling remained unclear.
Anna M Lipp +12 more
doaj +1 more source
Optic neuritis in CD59 deficiency: an extremely rare presentation
The Turkish Journal of Pediatrics, 2022 Background. CD59 is the principal cell inhibitor of complement membrane attack on cells. Stroke, peripheral neuropathy, and recurrent central nervous system attacks have been reported in patients with inherited CD59 deficiency.
Çağatay Günay +7 more
doaj +1 more source
Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2015 Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare type of acquired Haemolytic anaemia that is described as a triad of acquired intravascular Haemolysis, venous thrombosis and anaemia with pancytopenia sometimes due to bone marrow failure. However the
Archana Dambal +4 more
doaj +1 more source
Viruses, 2018 The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work has shown that ...
Yujia Li, Griffith D. Parks
doaj +1 more source
Mapping the Active Site of CD59 [PDF]
The Journal of Experimental Medicine, 1997 CD59 is a widely distributed membrane-bound inhibitor of the cytolytic membrane attack complex (MAC) of complement. This small (77 amino acid) glycoprotein is a member of the Ly6 superfamily of proteins and is important in protecting host cells from the lytic and proinflammatory activity of the MAC.
Yu, Jinghua +5 more
openaire +4 more sources
Cd59 and inflammation regulate Schwann cell development
eLife, 2022 Efficient neurotransmission is essential for organism survival and is enhanced by myelination. However, the genes that regulate myelin and myelinating glial cell development have not been fully characterized.
Ashtyn T Wiltbank +4 more
doaj +1 more source
Function of complement regulatory proteins in immunity of reproduction: a review
Czech Journal of Animal Science, 2005 Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová +2 more
doaj +1 more source
Journal of Neuroinflammation, 2023 Background Homozygous CD59-deficient patients manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), hemolytic anemia and recurrent strokes.
Netanel Karbian +9 more
doaj +1 more source
Autoimmunity, 2017 Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters.
Amanda Salviano-Silva +2 more
doaj +1 more source
Gecko CD59 is implicated in proximodistal identity during tail regeneration. [PDF]
PLoS ONE, 2011 Several adult reptiles, such as Gekko japonicus, have the ability to precisely re-create a missing tail after amputation. To ascertain the associated acquisition of positional information from blastemal cells and the underlying molecular mechanism of ...
Yongjun Wang +12 more
doaj +1 more source