Results 31 to 40 of about 10,623 (204)

Expression of CD55, CD59, and CD35 on red blood cells of β-thalassaemia patients

, 2017
Aim of the study : β-thalassaemia (β-Thal) is considered a severe, progressive haemolytic anaemia, which needs regular blood transfusions for life expectancy.
Mustafa Yildiz, Erdal Kurtoğlu, Ayşegül Uğur Kurtoğllu, Belkls Koçtekin, Selen Bozkurt   +4 more
core   +1 more source

Increased expression of complement regulators CD55 and CD59 on peripheral blood cells in patients with EAHEC O104:H4 infection.

PLoS ONE, 2013
BackgroundAn outbreak of Shiga Toxin 2 (Stx-2) producing enterohemorrhagic and enteroaggregative E.coli (EAHEC) O104H4 infection in May 2011 caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS).
Werner Dammermann, Pim Schipper, Sebastian Ullrich, Katharina Fraedrich, Julian Schulze Zur Wiesch, Thorben Fründt, Gisa Tiegs, Ansgar Lohse, Stefan Lüth   +8 more
doaj   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis [PDF]

, 2015
CD55, a glycosylphosphatidylinositol-anchored, complement-regulating protein (decay-accelerating factor), is expressed by fibroblast-like synoviocytes (FLS) with high local abundance in the intimal lining layer.
Tak, Paul P., J Verbeek, Paul P Tak, Arens, Ramon, Karpus, O.N., Hamann, J., Arens, R., Tak, P.P., Yilmaz-Elis, A. Seda, Birgit Niederreiter, Ramon Arens, Kiener, H.P., van der Kaa, Jos, Jörg Hamann, Ramaglia, Valeria, Verbeek, J.S., Verbeek, J. Sjef, Marina Botto, Botto, M., Valeria Ramaglia, Niederreiter, B., Kaa, J. van der, Hans P Kiener, A Yilmaz-Elis, Smolen, Josef S., Niederreiter, Birgit, Ramaglia, V., Josef S Smolen, Botto, Marina, Olga N Karpus, Yilmaz-Elis, A.S., Karpus, Olga N., Smolen, J.S., Kiener, Hans P., Hamann, Jörg, Jos van der Kaa   +35 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

O papel das proteínas reguladoras do complemento CD55/CD59 em células de sangue periférico de pacientes com lúpus eritematoso sistêmico The role of CD55/CD59 complement regulatory proteins on peripheral blood cells of systemic lupus erythematosus patients

Revista Brasileira de Reumatologia, 2009
CD55 e CD59 são proteínas de membrana ancoradas por glicosilfosfatidilinositol que apresentam propriedades reguladoras da ativação da cascata do complemento.
Ana Paula Alegretti, Tamara Mucenic, João Carlos Tavares Brenol, Ricardo Machado Xavier   +3 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer

Molecular Cancer
Background Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment of OC patients. Our previous studies identified cell surface CD55, a
Rashmi Bharti, Goutam Dey, Debjit Khan, Alex Myers, Olivia G. Huffman, Caner Saygin, Chad Braley, Elliott Richards, Naseer Sangwan, Belinda Willard, Justin D. Lathia, Paul L. Fox, Feng Lin, Babal Kant Jha, J. Mark Brown, Jennifer S. Yu, Mohammed Dwidar, Amy Joehlin-Price, Roberto Vargas, Chad M. Michener, Michelle S. Longworth, Ofer Reizes   +21 more
doaj   +1 more source

Bee Venom Alleviates Atopic Dermatitis Symptoms through the Upregulation of Decay-Accelerating Factor (DAF/CD55)

Toxins, 2019
Bee venom (BV)—a complex mixture of peptides and toxic proteins including phospholipase A2 and melittin—promotes blood clotting. In this study, we investigated the anti-atopic properties of BV and the mechanism associated with its regulation ...
Yenny Kim, Youn-Woo Lee, Hangeun Kim, Dae Kyun Chung   +3 more
doaj   +1 more source

Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies

Journal for ImmunoTherapy of Cancer, 2023
Background Oncolytic virus immunotherapy has revolutionized cancer immunotherapy by efficiently inducing both oncolysis and systemic immune activation.
Dong-Sup Lee, Mi-Ju Park, Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Byung-Jin Jung, Yun-Kyoung Hong, Keunhee Oh   +9 more
doaj   +1 more source