Results 51 to 60 of about 9,279 (174)

Genetic Determinants of Treatment‐Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 786-794, September 2026.
Osteonecrosis and fractures are serious corticosteroid‐induced bone toxicities in children treated for acute lymphoblastic leukemia, yet their genetic determinants remain incompletely defined. In this study, we aimed to identify novel genetic contributors to bone toxicity and to evaluate the robustness of both newly identified and previously ...
Rachid Abaji, Vincent Gagné, Émilie Espagne, Nathalie Alos, Veronica Del Vecchio, Lamia Ait Said, Albert Shalmiev, Claire Fuchs, Caroline Laverdière, Jean‐Marie Leclerc, Stephen E. Sallan, Lewis B. Silverman, Daniel Sinnett, Thai Hoa Tran, Maja Krajinovic   +14 more
wiley   +1 more source

Flow cytometric analysis of erythrocytes in paroxysmal nocturnal hemoglobinuria reveals superiority of CD59 as a diagnostic marker compared to CD55

Indian Journal of Pathology and Microbiology, 2010
Context: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 ...
Tembhare Prashant, Ramani Manisha, Syed Keerti, Gupta Amar   +3 more
doaj  

Detection of paroxysmal nocturnal hemoglobinuria-phenotype in patients with chronic lymphocytic leukemia and multiple myeloma

Indian Journal of Pathology and Microbiology, 2012
Background : Paroxysmal nocturnal hemoglobinuria (PNH) results due to decrease or absence of glycosylphosphatidylinositol-anchored (GPI) molecules, such as CD55 and CD59, from the surface of the affected cells. PNH-phenotype has been described in various
S Varma, N Varma, V V Reddy, S Naseem, P Bose, P Malhotra   +5 more
doaj   +1 more source

The Changing Landscape of Hantavirus Infections: A Narrative Review of Epidemiology, Pathogenesis, and Countermeasures

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria, Francesco Branda, Giancarlo Ceccarelli, Fabio Scarpa, Massimo Ciccozzi, Alessandro Russo   +5 more
wiley   +1 more source

Interactions of CD55 with non-complement ligands

Biochemical Society Transactions, 2002
Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection.
openaire   +3 more sources

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Multi‐Omics Integration Reveals That SN‐011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Ischemic stroke (IS) remains a leading cause of disability with limited therapeutic targets. Using multi‐omics integration, we identified ADGRE5 as a protective gene significantly downregulated in venous endothelial cells (vECs) during IS. JUNB acts as a key upstream transcription factor that negatively regulates ADGRE5 expression.
XiangLing Ou, ZunKe Gong
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, Volume 13, Issue 38, 9 July 2026.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

The decay-accelerating factor (CD55) in acute leukemia patients and its query implication in cancer pathogenesis

Journal of the Egyptian National Cancer Institute
Background The role of the complement system and its membrane-bound regulatory proteins (mCRPs) in the pathogenesis of cancer is still a debatable issue.
Hisham Abdelaziz, Mona Abdellateif, Ghada Elnaggar, Samar Kassem, Perihan Mohamed, Mohamed El Aziz, Khaled Abo-Aisha, Noha Farag, Noha Hassan   +8 more
doaj   +1 more source

Production of ULBP1-KO pigs with human CD55 expression using CRISPR technology

Journal of Applied Animal Research, 2020
The shortage of organs for transplantation is a well-known issue of modern medicine. The domestic pig has proved to be most suitable for xenotransplantation purposes.
Agnieszka Nowak-Terpiłowska, Daniel Lipiński, Magdalena Hryhorowicz, Wojciech Juzwa, Jacek Jura, Ryszard Słomski, Natalia Mazurkiewicz, Barbara Gawrońska, Joanna Zeyland   +8 more
doaj   +1 more source