Results 51 to 60 of about 10,623 (204)

Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants

Journal of Translational Medicine, 2020
Background Complement Regulatory Proteins (CRPs), especially CD55 primarily negate complement factor 3-mediated injuries and maintain tissue homeostasis during complement cascade activation.
Mohammad Afzal Khan, Talal Shamma, Shadab Kazmi, Abdullah Altuhami, Hala Abdalrahman Ahmed, Abdullah Mohammed Assiri, Dieter Clemens Broering   +6 more
doaj   +1 more source

Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion

Frontiers in Immunology, 2023
Background and aimsComplement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis.Materials and ...
Huan Tang, Huan Tang, Xinyue Hu, Xinyue Hu, Li Li, Shuanglinzi Deng, Shuanglinzi Deng, Yuanyuan Jiang, Yuanyuan Jiang, Lisha Luo, Lisha Luo, Runjin Cai, Runjin Cai, Yifei Yang, Yifei Yang, Chendong Wu, Chendong Wu, Xiaoxiao Gong, Xiaoxiao Gong, Juntao Feng, Juntao Feng   +20 more
doaj   +1 more source

Microglial Pruning of Excitatory Synapses in the Hippocampus Is Complement C3‐Independent in Physiological and Neuroinflammatory States

Glia, Volume 74, Issue 7, July 2026.
In development, microglia engulfment of hippocampal excitatory synapses is unperturbed in C3‐lacking mice. Peripheral inflammation induces a neuroinflammatory phenotype and synapse loss in the hippocampus independent of complement cascade activation. ABSTRACT A key feature of brain development is the refinement of exuberant synapses, known as synapse ...
Eric W. Salter, Ashish Kadia, Lijia Zhang, Jonathan S. Thacker, Sun‐Lim Choi, Liam T. Ralph, Gang Lei, Fuzi Jin, John Georgiou, Graham L. Collingridge   +9 more
wiley   +1 more source

Cellular Heterogeneity During Arterial Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu, Paul‐Lennard Mendez, Dimitri Kasakovski, Judith Sluimer   +3 more
wiley   +1 more source

Increased expression of CD55 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

, 2012
Purpose: To analyze the expression of complement delay-accelerating factor (CD55) in nasopharyngeal carcinoma and its correlation with clinicopathologic features, including survival rate.
Yin, Ruixue, Shen, Yumei, Deng, Xiaogang, Shen, Hong   +3 more
core   +2 more sources

Shifting From Systemic to Precision‐Targeted Complement Therapies: Opportunities and Hurdles

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Complement therapeutics have expanded considerably, but systemic inhibitors remain limited by infection risks, breakthrough events, and loss of physiological functions. Emerging targeted approaches aim for organ‐, tissue‐, or cell‐specific modulation of complement activity, potentially offering greater precision while reducing treatment burden and ...
Marco Mannes, Wioleta M. Zelek, Leendert A. Trouw   +2 more
wiley   +1 more source

Lack of CD55 causes a mild granulocytosis.

, 2013
Immune cells obtained from bone marrow, blood, and spleen of wild-type and Cd55-/- mice were incubated with antibodies against Ly6G (or Gr-1) and CD11b and analyzed by flow cytometry.
Feng-Qi An (342727), Alex F. de Vos (125066), Jörg Hamann (165328), M. Edward Medof (342733), Robert M. Hoek (243201), Tom van der Poll (33907), René A. W. van Lier (342731), Henrike Veninga (342722), Alex M. de Bruin (342725)   +8 more
core   +1 more source

Conditional gene knockout and reconstitution in human iPSCs with an inducible Cas9 system

Stem Cell Research, 2018
Precise genome editing in human induced pluripotent stem cells (iPSCs) significantly enhances our capability to use human iPSCs for disease modeling, drug testing and screening as well as investigation of human cell biology.
Mengyao Wu, Senquan Liu, Yongxing Gao, Hao Bai, Vasiliki Machairaki, Gang Li, Tong Chen, Linzhao Cheng   +7 more
doaj   +1 more source

Iptacopan monotherapy resulted in increased hemoglobin level in patients with PNH and hemoglobin ≥10 g/dL after anti‐C5 therapy

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Patients with paroxysmal nocturnal hemoglobinuria (PNH) on anti‐C5 often experience extravascular hemolysis with anemia. Iptacopan, the first oral proximal complement inhibitor targeting factor B, has shown efficacy and safety in PNH patients. APPULSE‐PNH (NCT05630001), a phase 3b, single‑arm, open‐label trial, enrolled adult patients with PNH
Austin Kulasekararaj, Flore S. de Fontbrune, Anna Gaya, Ilene Weitz, David J. Kuter, Bhumika J. Patel, David J. Araten, Abhay Singh, Jun H. Jang, Richard J. Kelly, Eros Di Bona, Michael Loschi, Vinod Pullarkat, Jörg Schubert, Rosario Notaro, Mustafa N. Yenerel, Joan Beckman, Nicolas Blin, Irina Murakhovskaya, Jens Panse, Eloy Roman, Alexander Röth, Hubert Schrezenmeier, Srinivas Tantravahi, Régis P. de Latour, Navin Mahajan, Luca Monaco, Tao Ding, Tomasz Lawniczek, Philippe Ferber, Marion Dahlke, Antonio M. Risitano   +31 more
wiley   +1 more source

Flow cytometric analysis of erythrocytes in paroxysmal nocturnal hemoglobinuria reveals superiority of CD59 as a diagnostic marker compared to CD55

Indian Journal of Pathology and Microbiology, 2010
Context: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by complement-mediated hemolysis due to reduced expression of glycosyl phosphatidylinositol-anchored complement deactivating proteins such as CD55 ...
Tembhare Prashant, Ramani Manisha, Syed Keerti, Gupta Amar   +3 more
doaj