Results 71 to 80 of about 10,623 (204)

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Identification of DAF1/CD55, a Novel Definitive Endoderm Marker

Cell Structure and Function, 2010
Although there are several markers available for the identification of endoderm derivatives such as the lung, pancreas, liver, and intestine, there are still very few surface markers available for the prospective isolation of the definitive endoderm. Among these, CXCR4 has been used in combination with E-cadherin as a cell surface marker to identify ...
Shiraki N, Harada S, Ogaki S, Kume K, Shoen Kume   +4 more
openaire   +3 more sources

Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children

G3: Genes, Genomes, Genetics, 2017
In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria.
Kathrin Schuldt, Christa Ehmen, Juergen Sievertsen, Jennifer Evans, Juergen May, Daniel Ansong, Birgit Muntau, Gerd Ruge, Christian Timmann, Tsiri Agbenyega, Rolf D. Horstmann, Thorsten Thye   +11 more
doaj   +1 more source

Production of ULBP1-KO pigs with human CD55 expression using CRISPR technology

Journal of Applied Animal Research, 2020
The shortage of organs for transplantation is a well-known issue of modern medicine. The domestic pig has proved to be most suitable for xenotransplantation purposes.
Agnieszka Nowak-Terpiłowska, Daniel Lipiński, Magdalena Hryhorowicz, Wojciech Juzwa, Jacek Jura, Ryszard Słomski, Natalia Mazurkiewicz, Barbara Gawrońska, Joanna Zeyland   +8 more
doaj   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Table_1_KLF4 and CD55 expression and function depend on each other.docx

The transcription factor Kruppel-like factor 4 (KLF4) regulates the expression of immunosuppressive and anti-thrombotic proteins. Despite its importance in maintaining homeostasis, the signals that control its expression and the mechanism of its ...
Feng-Qi An (342727), Guangjin Zhou (369032), Michael G. Strainic (17938745), Mukesh K. Jain (10807581), Wasim Hussain (17938742), M. Edward Medof (17938748), Micah T. Harland (17938739)   +6 more
core   +1 more source

Vpu does not downregulate surface levels of CD55 or EGFR.

, 2021
Cell-surface levels of CD55 and EGFR were measured in the presence of Vpu-FLAG by flow cytometry. Representative two-color flow plots are shown, CD4 was used as a positive control, GFP was used as a marker for transfection.
Sumit K. Chanda (11768006), Mark Ellisman (25776), Thomas Deerinck (450877), Charlotte A. Stoneham (10819125), John Lapek (10955076), David J. Gonzalez (4449451), John Guatelli (247378), Andrea Thor (11768003), Jacob M. Wozniak (4900267), Simon Langer (152875), Paul D. De Jesus (11768000), Lars Pache (562198)   +11 more
core   +1 more source

The potential role of cell surface complement regulators and circulating CD4+ CD25+ T-cells in the development of autoimmune myasthenia gravis

Electronic Physician, 2016
Introduction: CD4+CD25+ regulatory T-lymphocytes (T-regs) and regulators of complement activity (RCA) involving CD55 and CD59 play an important role in the prevention of autoimmune diseases.
Mohamed Nasreldin Thabit Hamdoon, Mona Fattouh, Asmaa Nasr El-din, Hassan M. Elnady   +3 more
doaj   +1 more source

Cardiovirulent Coxsackieviruses and the Decay-Accelerating Factor (CD55) Receptor

Virology, 1998
Group B coxsackieviruses are etiologically linked with many human diseases including acute myocarditis and associated chronic dilated cardiomyopathy. Well-established CVB3 cardiovirulent strains (CVB3c(s)) with known phenotypic difference have been used to study the pathogenesis of virus-induced heart disease.
Martino, Tami A., Petric, Martin, Brown, Martha, Aitken, Karen, Gauntt, Charles J., Richardson, Christopher D., Chow, Lawrence H., Liu, Peter P.   +7 more
openaire   +2 more sources

Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia

Platelets, 2017
In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger, Beate Eichelberger, Anja Ulz, Simon Panzer   +3 more
doaj   +1 more source