Results 61 to 70 of about 9,279 (174)

An interpretable multi‐task whole‐slide histopathology AI model for non‐small cell lung cancer: Cross‐cohort generalisation, spatial attention–transcriptomic integration, and molecular–immune profiling

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
SparseAGE‐MTL analyses routine haematoxylin and eosin pathology images from multicentre non‐small cell lung cancer cohorts to generate subtype‐classification, stage‐probability and survival‐risk outputs. Task‐specific attention maps and risk scores were integrated with spatial and bulk transcriptomics, linking high‐attention regions and high‐risk cases
Renyi Lu, Anqi Lin, Aimin Jiang, Yuying Feng, Xiuhui Fang, Junyi Shen, Yifeng Bai, Shengkun Peng, Jian Zhang, Quan Cheng, Suyin Feng, Qinglin Li, Peng Luo   +12 more
wiley   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

CD55 polymorphisms and risk of aspirin-exacerbated respiratory disease

Molecular Medicine Reports, 2012
Aspirin-exacerbated respiratory disease (AERD) is a respiratory disease characterized by acute bronchial responses upon the administration of non-steroidal anti‑inflammatory drugs (NSAIDs) and the immune response by mast cells is regarded as one of the noteworthy causes of AERD pathogenesis. The complement cascade is
Jin Sol, Lee, Joon Seol, Bae, Jeong-Hyun, Kim, Jason Yongha, Kim, Tae Joon, Park, Charisse Flerida, Pasaje, Byung-Lae, Park, Hyun Sub, Cheong, Soo-Taek, Uh, An-Soo, Jang, Inseon S, Choi, Choon-Sik, Park, Hyoung Doo, Shin   +12 more
openaire   +3 more sources

Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children

G3: Genes, Genomes, Genetics, 2017
In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria.
Kathrin Schuldt, Christa Ehmen, Juergen Sievertsen, Jennifer Evans, Juergen May, Daniel Ansong, Birgit Muntau, Gerd Ruge, Christian Timmann, Tsiri Agbenyega, Rolf D. Horstmann, Thorsten Thye   +11 more
doaj   +1 more source

Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia

Platelets, 2017
In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger, Beate Eichelberger, Anja Ulz, Simon Panzer   +3 more
doaj   +1 more source

The potential role of cell surface complement regulators and circulating CD4+ CD25+ T-cells in the development of autoimmune myasthenia gravis

Electronic Physician, 2016
Introduction: CD4+CD25+ regulatory T-lymphocytes (T-regs) and regulators of complement activity (RCA) involving CD55 and CD59 play an important role in the prevention of autoimmune diseases.
Mohamed Nasreldin Thabit Hamdoon, Mona Fattouh, Asmaa Nasr El-din, Hassan M. Elnady   +3 more
doaj   +1 more source

Concurrent Loss of PIGA and ZRSR2 in a Patient With Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Neoplasm

International Journal of Laboratory Hematology, EarlyView.
Fatma AlBulushi, Eric McGinnis
wiley   +1 more source

Identification of DAF1/CD55, a Novel Definitive Endoderm Marker

Cell Structure and Function, 2010
Although there are several markers available for the identification of endoderm derivatives such as the lung, pancreas, liver, and intestine, there are still very few surface markers available for the prospective isolation of the definitive endoderm. Among these, CXCR4 has been used in combination with E-cadherin as a cell surface marker to identify ...
Shiraki N, Harada S, Ogaki S, Kume K, Shoen Kume   +4 more
openaire   +3 more sources

A Histological Analysis and Detection of Complement Regulatory Protein CD55 in SARS-CoV-2 Infected Lungs

Life
Background: A complement imbalance in lung alveolar tissue can play a deteriorating role in COVID-19, leading to acute respiratory distress syndrome (ARDS). CD55 is a transmembrane glycoprotein that inhibits the activation of the complement system at the
Sandeep Silawal, Clemens Gögele, Petr Pelikan, Christian Werner, Georgia Levidou, Raman Mahato, Gundula Schulze-Tanzil   +6 more
doaj   +1 more source

Cardiovirulent Coxsackieviruses and the Decay-Accelerating Factor (CD55) Receptor

Virology, 1998
Group B coxsackieviruses are etiologically linked with many human diseases including acute myocarditis and associated chronic dilated cardiomyopathy. Well-established CVB3 cardiovirulent strains (CVB3c(s)) with known phenotypic difference have been used to study the pathogenesis of virus-induced heart disease.
Martino, Tami A., Petric, Martin, Brown, Martha, Aitken, Karen, Gauntt, Charles J., Richardson, Christopher D., Chow, Lawrence H., Liu, Peter P.   +7 more
openaire   +2 more sources