Results 61 to 70 of about 10,623 (204)

Detection of paroxysmal nocturnal hemoglobinuria-phenotype in patients with chronic lymphocytic leukemia and multiple myeloma

Indian Journal of Pathology and Microbiology, 2012
Background : Paroxysmal nocturnal hemoglobinuria (PNH) results due to decrease or absence of glycosylphosphatidylinositol-anchored (GPI) molecules, such as CD55 and CD59, from the surface of the affected cells. PNH-phenotype has been described in various
S Varma, N Varma, V V Reddy, S Naseem, P Bose, P Malhotra   +5 more
doaj   +1 more source

Deletion of either CD55 or CD97 ameliorates arthritis [PDF]

Annals of the Rheumatic Diseases, 2010
CD55 (decay accelerating factor) is best known for its role in the negative regulation of the complement system. Indeed, lack of this molecule leads to disease aggravation in many inflammatory disease models. However, CD55 is abundantly present on fibroblast-like …
R M Hoek, D de Launay, E N Kop, A S Yilmaz-Elis, O Karpus, F Lin, K A Reedquist, J S Verbeek, M E Medof, P P Tak, J Hamann   +10 more
openaire   +1 more source

Flow cytometric analysis of CD55 and CD59 expression on blood cells in paroxysmal nocturnal haemoglobinuria

Folia Histochemica et Cytobiologica, 2011
PNH is a rare clonal disorder of hematopoietic stem cells, therefore all blood cells lineages are involved. The main feature is an increased sensitivity of erythrocytes to complement-mediated cell lysis due to deficiency of membrane-bound GPI ...
Anna Czyz, Iwona Mozer-Lisewska, Magdalena Trybus, Ewa Mizera-Nyczak, Jan Sikora, Grzegorz Dworacki, Jan Zeromski   +6 more
doaj   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Reduced Hypotonic Exposure and Sequential Membrane Cholesterol Enrichment Limit Phosphatidylserine Externalization and Enhance Circulatory Retention of Erythrocyte‐Derived Microparticles

Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.
ABSTRACT Erythrocyte‐derived carriers have emerged as effective biomimetic platforms for the delivery of therapeutic and imaging cargos. However, clearance by the mononuclear phagocytic system (MPS) limits their utility. Towards development of standardized methods for increased bioavailability, we have developed an approach that lowers the ...
Shamima Zaman, Grant Swajian, Shiril Bhardwaj Iragavarapu, Md Tashdid Hossain Shoudho, Bahman Anvari   +4 more
wiley   +1 more source

The decay-accelerating factor (CD55) in acute leukemia patients and its query implication in cancer pathogenesis

Journal of the Egyptian National Cancer Institute
Background The role of the complement system and its membrane-bound regulatory proteins (mCRPs) in the pathogenesis of cancer is still a debatable issue.
Hisham Abdelaziz, Mona Abdellateif, Ghada Elnaggar, Samar Kassem, Perihan Mohamed, Mohamed El Aziz, Khaled Abo-Aisha, Noha Farag, Noha Hassan   +8 more
doaj   +1 more source

Multi‐Layered Genomic and Clinical Analysis Identifies Novel Variants, Co‐Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host‐Pathogen Interaction in COVID‐19 Severity

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Host genetic factors may contribute to COVID‐19 severity. To identify genetic variants influencing COVID‐19 severity progression, whole‐exome sequencing was performed, followed by an exome‐wide association study on 191 hospitalized patients categorized into three severity groups.
Doris Repušić, Marina Korolija, Ana Livun, Tomo Svaguša, Robert Belužić, Vjekoslav Tomaić, Rosa Karlić, Kristian Vlahoviček   +7 more
wiley   +1 more source

CD55 polymorphisms and risk of aspirin-exacerbated respiratory disease

Molecular Medicine Reports, 2012
Aspirin-exacerbated respiratory disease (AERD) is a respiratory disease characterized by acute bronchial responses upon the administration of non-steroidal anti‑inflammatory drugs (NSAIDs) and the immune response by mast cells is regarded as one of the noteworthy causes of AERD pathogenesis. The complement cascade is
Jin Sol, Lee, Joon Seol, Bae, Jeong-Hyun, Kim, Jason Yongha, Kim, Tae Joon, Park, Charisse Flerida, Pasaje, Byung-Lae, Park, Hyun Sub, Cheong, Soo-Taek, Uh, An-Soo, Jang, Inseon S, Choi, Choon-Sik, Park, Hyoung Doo, Shin   +12 more
openaire   +3 more sources

A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells

, 2018
Guoxiang Liu, Qifeng Yin, Huanhuan Ji, Yujuan Wang, Huihui Liu, Liangqian Jiang, Feng Zhu, Bing Li Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, People’s Republic of China Background: To ...
Liu H, Jiang L, Ji H, Yin Q, Zhu F, Li B, Wang Y, Liu G   +7 more
core  

Single‐Cell and Spatial Transcriptomics Uncover Immune Dynamics and Cellular Heterogeneity in Benign Prostatic Hyperplasia and Prostate Cancer Transition

MedComm, Volume 7, Issue 6, June 2026.
Leveraging integrated single‐cell and spatial transcriptomics, we delineated the sustained immunosuppressive landscape during prostate disease progression. Based on this, we have developed a precise gene‐based diagnostic classifier and a multimodal prognostic model.
Yuanyuan Luo, Haitao Zhong, Tongrui Shang, Bin Hu, Dongbo Yuan, Xueyuan Jia, Ruichong Lin, Zehua Wang, Yinyi Fang, Guohua Zhu, Jukun Song, Zhangcheng Liu, Bo Yan, Fa Sun, Zhenyu Jia, Yunfang Yu, Luhui Mao, Hai Huang, Jianguo Zhu   +18 more
wiley   +1 more source