CD55 may be an important prognostic factor of thymic epithelial tumors: a retrospective study [PDF]
World Journal of Surgical OncologyBackground Thymic epithelial tumors (TETs) currently lack effective prognostic factors and novel treatment approaches, the aim of the study is to investigate the expression of CD55 in TETs and the relationship with clinicopathological characteristics and
Jiao Ma +11 more
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The Function of Transforming Growth Factor 2 in Facilitating Inflammasome Activation to Enhance the Development of Myopia via Complement System [PDF]
CellsMyopia is one of the major public health conditions with significant complications. This study investigates the role of transforming growth factor (TGF)-β2, complement activation, and inflammasome pathways in myopia progression using a Brown Norway rat ...
Sheng-Chun Lin +11 more
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Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells [PDF]
eLifeTendons and ligaments are crucial connective tissues linking bones and muscles, yet achieving full functional recovery after injury remains challenging.
Hiroki Tsutsumi +8 more
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GDPD5-CD55-EGFR competitive binding axis regulates radioresistance and lipid accumulation in rectal cancer [PDF]
Cell Death and DiseaseResistance to neoadjuvant chemoradiotherapy in rectal cancer diminishes survival benefits, potentially due to dysregulated lipid metabolism, though the mechanisms are unclear.
Ruiqiu Zhu +7 more
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CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responses [PDF]
Communications BiologyComplement overactivation, has been verified in COVID-19 patients. Complement regulatory proteins, including CD55, control complement overactivation thus eliminating complement deposition and cell lysis.
Maria G. Detsika +11 more
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Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts. [PDF]
PLoS ONE, 2012 BACKGROUND:CD55 (decay-accelerating factor) is a complement-regulatory protein highly expressed on fibroblast-like synoviocytes (FLS). CD55 is also a ligand for CD97, an adhesion-type G protein-coupled receptor abundantly present on leukocytes. Little is
Olga N Karpus +4 more
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Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2015 Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare type of acquired Haemolytic anaemia that is described as a triad of acquired intravascular Haemolysis, venous thrombosis and anaemia with pancytopenia sometimes due to bone marrow failure. However the
Archana Dambal +4 more
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Function of complement regulatory proteins in immunity of reproduction: a review
Czech Journal of Animal Science, 2005 Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová +2 more
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Beyond the Role of CD55 as a Complement Component [PDF]
Immune Network, 2018 The complement is a part of the immune system that plays several roles in removing pathogens. Despite the importance of the complement system, the exact role of each component has been overlooked because the complement system was thought to be a nonspecific humoral immune mechanism that worked against pathogens.
Dho, So Hee +2 more
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Alteration of membrane complement regulators is associated with transporter status in patients on peritoneal dialysis. [PDF]
PLoS ONE, 2017 INTRODUCTION:A growing body of evidence from animal models and cell culture studies indicate an important role of a local regulatory complement system (CS) in peritoneal injury during peritoneal dialysis (PD).
Daniel Kitterer +5 more
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