Results 11 to 20 of about 10,623 (204)

Beyond the Role of CD55 as a Complement Component [PDF]

Immune Network, 2018
The complement is a part of the immune system that plays several roles in removing pathogens. Despite the importance of the complement system, the exact role of each component has been overlooked because the complement system was thought to be a nonspecific humoral immune mechanism that worked against pathogens.
Dho, So Hee, Lim, Jae Cheong, Kim, Lark Kyun   +2 more
openaire   +5 more sources

Loss of CD55 Is Associated with Aggressive Breast Tumors [PDF]

Clinical Cancer Research, 2004
Abstract Purpose: CD55 is a complement regulatory protein expressed by cells to protect them from bystander attack by complement. CD55 is overexpressed on some tumor cell lines, and in colorectal carcinomas, it has been shown to be an indicator of poor prognostic.
Madjd, Zahra, Durrant, Lindy G, Bradley, Richard, Spendlove, Ian, Ellis, Ian O, Pinder, Sarah E   +5 more
openaire   +4 more sources

Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia [PDF]

Malaria Journal, 2011
Background Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process.
Gwamaka Moses, Fried Michal, Domingo Gonzalo, Duffy Patrick E   +3 more
doaj   +2 more sources

CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever

mBio, 2022
Relapsing fever, caused by diverse Borrelia spirochetes, is prevalent in many parts of the world and causes significant morbidity and mortality. To investigate the pathoetiology of relapsing fever, we performed a high-throughput screen of Borrelia ...
Gunjan Arora, Geoffrey E. Lynn, Xiaotian Tang, Connor E. Rosen, Dieuwertje Hoornstra, Andaleeb Sajid, Joppe W. Hovius, Noah W. Palm, Aaron M. Ring, Erol Fikrig   +9 more
doaj   +2 more sources

Interactions of CD55 with non-complement ligands

Biochemical Society Transactions, 2002
Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection.
Lea, S
openaire   +4 more sources

Overexpression of Human CD55 and CD59 or Treatment with Human CD55 Protects against Renal Ischemia-Reperfusion Injury in Mice [PDF]

The Journal of Immunology, 2017
Abstract Deficiency in the membrane-bound complement regulators CD55 and CD59 exacerbates renal ischemia-reperfusion injury (IRI) in mouse models, but the effect of increasing CD55 and CD59 activity has not been examined. In this study, we investigated the impact of overexpression of human (h) CD55 ± hCD59 or treatment with soluble ...
Anjan K Bongoni, Bo Lu, Evelyn J Salvaris, Veena Roberts, Doreen Fang, Jennifer L McRae, Nella Fisicaro, Karen M Dwyer, Peter J Cowan   +8 more
core   +4 more sources

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

New England Journal of Medicine, 2017
Studies of monogenic gastrointestinal diseases have revealed molecular pathways critical to gut homeostasis and enabled the development of targeted therapies.We studied 11 patients with abdominal pain and diarrhea caused by early-onset protein-losing enteropathy with primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and ...
Krolo, Ana, KIYKIM, Ayça, Baris, Zeren, GÜLŞAN, MELTEM, ÖĞÜLÜR, İSMAİL, Snapper, Scott B., Houwen, Roderick H. J., Lenardo, Michael J., Sari, SİNAN, BARIŞ, SAFA, Serwas, Nina K., Zhang, Yu, Matthews, Helen F., Pittaluga, Stefania, Folio, Les R., Aksu, Aysel Unlusoy, McElwee, Joshua J., Boztug, Kaan, ÖZEN, AHMET OĞUZHAN, Comrie, William A., Ardy, Rico C., Conde, Cecilia Dominguez, BEŞER, Ömer Faruk, Morawski, Aaron R., Karakoc-Aydiner, Elif, TUTAR, ENGİN, Ozcay, Figen, DALGIÇ, BUKET, Leavis, Helen L., ERTEM ŞAHİNOĞLU, DENİZ, Kain, Renate, Erkan, Tulay, Su, Helen C.   +32 more
core   +9 more sources

Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts. [PDF]

PLoS ONE, 2012
BACKGROUND:CD55 (decay-accelerating factor) is a complement-regulatory protein highly expressed on fibroblast-like synoviocytes (FLS). CD55 is also a ligand for CD97, an adhesion-type G protein-coupled receptor abundantly present on leukocytes. Little is
Olga N Karpus, Kirstin M Heutinck, Paul J M Wijnker, Paul P Tak, Jörg Hamann   +4 more
doaj   +2 more sources

A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.

PLoS ONE, 2011
BackgroundIn addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97
Henrike Veninga, Robert M Hoek, Alex F de Vos, Alex M de Bruin, Feng-Qi An, Tom van der Poll, René A W van Lier, M Edward Medof, Jörg Hamann   +8 more
doaj   +2 more sources

Periferal Lökositlerde CD35, CD46, CD55 ve CD59 Düzeyleri

Genel Tıp Dergisi, 2017
Giriş: Kompleman aktivasyonunun, hedef molekül dışında bulunan çevre dokulara zarar vermesini kompleman düzenleyici proteinler engeller. Özellikle CD35, CD46, CD55 ve CD59 hastalıklarla ilişkilendirilen kompleman düzenleyici proteinlerdir.
Aydan Karagül, Belkıs Koçtekin, Sevcan Uğur, Ayşegül Uğur Kurtoğlu   +3 more
doaj   +2 more sources