Results 21 to 30 of about 3,779 (110)
Small, EarlyView.Bioinspired triglyceride‐ceramide lipid nanoparticles were reverse‐engineered from cytokine‐sequestering plant‐derived nanoparticles to capture pathological inflammatory mediators through protein corona formation. Dexamethasone‐loaded TCNPs combine extracellular cytokine sequestration with intracellular immunomodulation, reducing IL‐6, TNF‐α, and NF‐κΒ
Junsik J. Sung +2 more
wiley +1 more source
The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders
Brain Pathology, EarlyView.Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu +11 more
wiley +1 more source
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source
Reviews in Medical Virology, Volume 36, Issue 5, September 2026.ABSTRACT Hantaviruses are emerging zoonotic pathogens of increasing global public health significance. Their epidemiological landscape is rapidly changing due to ecological disruption, climate variability, urbanisation, and evolving human–animal interfaces.
Francesco De Maria +5 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.Ischemic stroke (IS) remains a leading cause of disability with limited therapeutic targets. Using multi‐omics integration, we identified ADGRE5 as a protective gene significantly downregulated in venous endothelial cells (vECs) during IS. JUNB acts as a key upstream transcription factor that negatively regulates ADGRE5 expression.
XiangLing Ou, ZunKe Gong
wiley +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, Volume 13, Issue 38, 9 July 2026.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
A study on screening and antitumor effect of CD55-specific ligand peptide in cervical cancer cells
Drug Design, Development and Therapy, 2018 Guoxiang Liu, Qifeng Yin, Huanhuan Ji, Yujuan Wang, Huihui Liu, Liangqian Jiang, Feng Zhu, Bing Li Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, People’s Republic of China Background: To ...
Liu G +7 more
doaj
Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?
European Journal of Immunology, Volume 56, Issue 7, July 2026.Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni +4 more
wiley +1 more source
DETECTION AND FOLLOW UP OF PNH CLONE BY MEASURING CD55 AND CD59 EXPRESSION ON NEUTROPHILS
Zdravniški Vestnik, 2004 Background. Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal haematopoietic stem cell disorder characterised by intravascular haemolysis, bone marrow failure and increased tendency to thrombosis.
Uroš Mlakar, Darja Žontar
doaj
Complement Factor H‐Based Therapeutics: A Comprehensive Overview
European Journal of Immunology, Volume 56, Issue 7, July 2026.Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H‐based therapeutic concepts and modalities to treat complement‐mediated diseases.
Sebastiaan M. W. R. Hamers +2 more
wiley +1 more source