Results 1 to 10 of about 113,435 (208)

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase [PDF]

Proceedings of the National Academy of Sciences, 2009
Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of genes necessary for cellular processes including DNA replication.
Kamil, Jeremy P., Hume, Adam J., Jurak, Igor, Münger, Karl, Kalejta, Robert F., Coen, Donald M.   +5 more
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Active disassembly of the first complement component, C-1, by C-1 inactivator.

Journal of Immunology, 1979
In order to clarify its mechanism of disassembly, the first component of human complement, C1, was reconstituted from C1q, 125I-C1r, and 131I-C1s. This radiolabeled C1 bound tightly to aggregated IgG covalently linked to Sepharose 4B.
R. Ziccardi, Neil R. Cooper
semanticscholar   +1 more source

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface [PDF]

Infection and Immunity, 2019
Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked.
Kashif S. Haleem, Youssif M. Ali, Hasan Yesilkaya, Thomas Kohler, Sven Hammerschmidt, Peter W. Andrew, Wilhelm J. Schwaeble, Nicholas J. Lynch   +7 more
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The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system.

Journal of Immunology, 1983
Pneumococcal cell walls are potent activators of the alternative complement (C) pathway; pneumococcal capsules are not. C3b that is deposited onto the cell walls of encapsulated organisms, however, functions inefficiently in host defense compared to C3b ...
E. Brown, K. Joiner, T. Gaither, C. Hammer, M. Frank   +4 more
semanticscholar   +1 more source

CD55 is a key complement regulatory protein that counteracts complement-mediated inactivation of Newcastle Disease Virus

Journal of General Virology, 2016
Newcastle disease virus (NDV) is being developed as an oncolytic virus for virotherapy. In this study we analysed the regulation of complement-mediated inactivation of a recombinant NDV in different host cells. NDV grown in human cells was less sensitive to complement-mediated virus inactivation than NDV grown in embryonated chicken eggs. Additionally,
Udaya S, Rangaswamy, Christopher R, Cotter, Xing, Cheng, Hong, Jin, Zhongying, Chen   +4 more
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Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties [PDF]

Scientific Reports, 2017
Abstract Borrelia (B.) miyamotoi , an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
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Tumor Cell Complementation Groups Based on Myogenic Potential: Evidence for Inactivation of Loci Required for Basic Helix-Loop-Helix Protein Activity [PDF]

Molecular and Cellular Biology, 1996
Basic helix-loop-helix (bHLH) proteins mediate terminal differentiation in many lineages. By using the bHLH protein MyoD, which can dominantly activate the myogenic differentiation program in numerous cell types, we demonstrated that recessive defects in bHLH protein function are present in human tumor lines. In contrast to prior work with primary cell
A N, Gerber, S J, Tapscott
openaire   +2 more sources

Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes

Journal of Experimental Medicine, 1980
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3, factors B (B) and D (D), and properdin, the regulatory proteins C3b inactivator (C3bINA) and beta 1H, in addition to C2, C4,
K. Whaley
semanticscholar   +1 more source

Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins

Journal of Experimental Medicine, 1977
Cleavage of C3 by the alternative complement pathway occurs in at least two distinct phases: continuous low grade generation of C3b by the interaction of native C3, B, D, and P, and subsequent amplified cleavage of C3 by the interaction of C3b, B, D, and
D. Fearon, K. Austen
semanticscholar   +1 more source

Detection by Paper Electrophoresis of the Protein Denaturation in Heat-inactivated Serum for the Complement Fixation Reaction [PDF]

Nature, 1956
IN seeking the mechanism to explain an apparent procomplementary activity to canine complement of canine serum activated at 56° C. for 30 min., it was observed that the same serum was anticomplementary if inactivated at 62° C. instead of 56° C.
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