Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Human complement C4 is one of the most diverse but heritable effectors for humoral immunity. To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including ...
Sasigarn Bowden +2 more
exaly +5 more sources
Real-time PCR quantification of human complement C4A and C4B genes [PDF]
BMC Genetics, 2006 Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George +5 more
doaj +5 more sources
Multifaceted Activities of Seven Nanobodies against Complement C4b [PDF]
The Journal of Immunology, 2022 Abstract Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation of C4 and other initial components of the classical pathway may cause or aggravate pathologies, such as ...
Karla I De la O Becerra +9 more
core +9 more sources
Clinical features of patients with homozygous complement C4A or C4B deficiency. [PDF]
PLoS ONE, 2018 IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa +4 more
doaj +5 more sources
Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia. [PDF]
PLoS ONE, 2012 Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis.
Sven Malm +5 more
doaj +5 more sources
Human pentraxin 3 binds to the complement regulator c4b-binding protein.
PLoS ONE, 2011 The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells.
Anne Braunschweig, Mihály Józsi
doaj +4 more sources
Significance of urine complement proteins in monitoring lupus activity [PDF]
PeerJ, 2022 Objectives Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported.
Jin Zhao +5 more
doaj +2 more sources
Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus
Viruses, 2021 Adenovirus (AdV) infection elicits a strong immune response with the production of neutralizing antibodies and opsonization by complement and coagulation factors.
Corey C. Emerson, Phoebe L. Stewart
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 Complement system plays an important role in the immune defense against pathogens; however, recent studies demonstrated an important role of complement subunits C1q, C4, and C3 in normal functions of the central nervous system (CNS) such as non ...
Tatyana Veremeyko +8 more
doaj +1 more source
The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35) [PDF]
The Journal of Immunology, 2004 Abstract Several previous reports concluded that the C4b fragment of human C4A (C4Ab) binds with higher affinity to CR1 than does C4Bb. Because the isotypic residues, 1101PCPVLD and 1101LSPVIH in C4A and C4B, respectively, are located within the C4d region, one may have expected a direct binding contribution of C4d to the interaction ...
Clemenza, Liliana, Isenman, David E.
openaire +5 more sources