Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases [PDF]
Frontiers in Immunology, 2021 Human complement C4 is one of the most diverse but heritable effectors for humoral immunity. To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including ...
Danlei Zhou +2 more
exaly +7 more sources
A case report of complement C4B deficiency in a patient with steroid and IVIG-refractory anti-NMDA receptor encephalitis [PDF]
BMC Neurology, 2020 Background Complement C4A or C4B deficiency has never been reported in autoantibody-associated encephalitides patient. Here we present a case of anti-N-methyl- D-aspartate (NMDA) receptor encephalitis associated with homozygous C4B deficiency, who did ...
Gilbert T. Chua +5 more
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Structural and Functional Analysis of Porcine CR1-like Proteins in C4b-Mediated Immune Responses [PDF]
Veterinary SciencesThe complement system is crucial for immune defense, linking innate and adaptive immunity. In the classical and lectin pathways, C4 is split into C4b, triggering opsonization, lysis, and the removal of pathogens and damaged cells. Dysregulated activation
Wei Yin +13 more
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Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort [PDF]
Translational PsychiatryThe T Helper (Th)1-Th2 imbalance has been observed during the transition from the clinical high-risk (CHR) state to psychosis. However, it remains unclear whether the complement system influences this imbalance during psychosis onset. This study aimed to
TianHong Zhang +17 more
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Divergence of C4A and C4B in first-episode psychosis: Insights from CSF and plasma immune profiling [PDF]
Translational PsychiatryThe complement genes C4A and C4B share high sequence similarity yet differ in biological function and disease relevance. C4A, in contrast to C4B, is implicated in synaptic pruning and increased risk for schizophrenia, however beyond this their distinct ...
Shokouh Arjmand +9 more
doaj +2 more sources
Complement profiling for treatment outcomes in pulmonary TB [PDF]
Frontiers in ImmunologyIntroductionThe complement system plays a vital role in the immune response against tuberculosis (TB), aiding in the recognition and clearance of Mycobacterium tuberculosis.
Nathella Pavan Kumar +11 more
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Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]
PLoS ONE, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab +7 more
doaj +5 more sources
In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients [PDF]
Scientific ReportsIn the overactivation of the complement, the role of classical pathway is still not thoroughly investigated in COVID-19. Our aim was to examine the connection between SARS-CoV-2-specific antibodies, in vitro complement activation, and in vivo complement ...
Petra Kiszel +5 more
doaj +2 more sources
Association between copy number variation of complement component
Journal of Biomedical Science, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling +7 more
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Differential complement pathways and components in the clinical spectrum of systemic lupus erythematosus [PDF]
Arthritis Research & TherapyObjectives The precise contributions of the classical (CP), lectin (LP), and alternative (AP) pathways to systemic lupus erythematosus (SLE) remain incompletely understood.
Haijun Ma +3 more
doaj +2 more sources