Degradation of human complement component C4b in the presence of the C4b-binding protein-protein S complex [PDF]
Biochemical Journal, 1983 Vitamin K-dependent protein S and the higher-molecular-weight form of C4b-binding protein (C4bp-high) interact, forming a 1:1 complex with a KD of approx. 1×10(-7) M [Dahlbäck (1983) Biochem. J. 209, 847-856]. In the present study the effect of protein S on the degradation of C4b by Factor I (C3b inactivator) and C4bp was investigated both in fluid ...
B, Dahlbäck, B, Hildebrand
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Frontiers in Immunology, 2022 Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries +6 more
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Molecules, 2022 Exosomes are small extracellular vesicles with a variable protein cargo in consonance with cell origin and pathophysiological conditions. Gestational diabetes mellitus (GDM) is characterized by different levels of chronic low-grade inflammation and ...
Elena G. Bernea +9 more
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Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. [PDF]
PLoS ONE, 2012 Microbial pathogens acquire the immediate imperative to avoid or counteract the formidable defense of innate immunity as soon as they overcome the initial physical barriers of the host. Many have adopted the strategy of directly disrupting the complement
Henry A Choy
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Hypomorphic C4B∗ 15 variant of the fourth component of complement [PDF]
FEBS Letters, 1990 We report a rare ‘hypomorphic’ C4 allotype detected during routine screening in controls for the Rogers:1 epitope. C4B∗15 was distinguished by having only faint staining when using polyclonal anti‐C4 antibody on agarose inimunoelectrophoresis (e.g.
Christenson, Marie J. +4 more
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C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus
Frontiers in Immunology, 2021 C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions as a
Praveen M. Varghese +11 more
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The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]
PLoS ONE, 2009 Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros +7 more
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Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]
, 2009 Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie +26 more
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Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]
, 2004 The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek +19 more
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CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]
, 1991 Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Estaller, C. +4 more
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