Molecules, 2022 Exosomes are small extracellular vesicles with a variable protein cargo in consonance with cell origin and pathophysiological conditions. Gestational diabetes mellitus (GDM) is characterized by different levels of chronic low-grade inflammation and ...
Elena G. Bernea +9 more
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Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. [PDF]
PLoS ONE, 2012 Microbial pathogens acquire the immediate imperative to avoid or counteract the formidable defense of innate immunity as soon as they overcome the initial physical barriers of the host. Many have adopted the strategy of directly disrupting the complement
Henry A Choy
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The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes. [PDF]
PLoS ONE, 2009 Saliva of haematophagous arthropods contain biomolecules involved directly or indirectly with the haematophagy process, and among them are encountered some complement system inhibitors.
Veruska Cavalcanti Barros +7 more
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C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus
Frontiers in Immunology, 2021 C4b Binding Protein (C4BP) is a major fluid phase inhibitor of the classical and lectin pathways of the complement system. Complement inhibition is achieved by binding to and restricting the role of activated complement component C4b. C4BP functions as a
Praveen M. Varghese +11 more
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Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism [PDF]
, 2016 During the activation of complement C4 to C4b, the exposure of its thioester domain (TED) is crucial for the attachment of C4b to activator surfaces. In the C4b crystal structure, TED forms an Arg(104)-Glu(1032) salt bridge to tether its neighbouring ...
Fung, KW +4 more
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Degradation of human complement component C4b in the presence of the C4b-binding protein-protein S complex [PDF]
Biochemical Journal, 1983 Vitamin K-dependent protein S and the higher-molecular-weight form of C4b-binding protein (C4bp-high) interact, forming a 1:1 complex with a KD of approx. 1×10(-7) M [Dahlbäck (1983) Biochem. J. 209, 847-856]. In the present study the effect of protein S on the degradation of C4b by Factor I (C3b inactivator) and C4bp was investigated both in fluid ...
B, Dahlbäck, B, Hildebrand
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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
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Hypomorphic C4B∗ 15 variant of the fourth component of complement [PDF]
FEBS Letters, 1990 We report a rare ‘hypomorphic’ C4 allotype detected during routine screening in controls for the Rogers:1 epitope. C4B∗15 was distinguished by having only faint staining when using polyclonal anti‐C4 antibody on agarose inimunoelectrophoresis (e.g.
Christenson, Marie J. +4 more
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Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]
, 2016 Item does not contain ...
Atkinson, John P +14 more
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CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]
, 1991 Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Dierich, Manfred P. +4 more
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