Results 41 to 50 of about 9,987 (203)

The Molecular Mechanisms of Complement Receptor 1—It Is Complicated

Biomolecules, 2023
Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on the
Matthew P. Hardy, Mariam Mansour, Tony Rowe, Sandra Wymann   +3 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

Increased frequency of the null allele at the complement C4b locus in autism [PDF]

Clinical and Experimental Immunology, 1991
SUMMARY Associations between C4 deficiency and autoimmune disorders have been found over the past several years. Since autism has several autoimmune features, the frequencies of null (no protein produced) alleles at the C4A and C4B loci were studied in 19 subjects with autism and their family members.
R P, Warren, V K, Singh, P, Cole, J D, Odell, C B, Pingree, W L, Warren, E, White   +6 more
openaire   +2 more sources

Complement C4A Regulates Autoreactive B Cells in Murine Lupus

Cell Reports, 2020
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll   +6 more
doaj   +1 more source

Function of the activated fourth component of complement (C4b) in activation of C2 [PDF]

FEBS Letters, 1982
In course of pathway activation fourth component complement is by acCT into (8800 M,) C4b (197 M,). It well known C4b forms reversible complex the second of compleC2, with essential participation Mg2+ [ 1,2]. Furthermore, C4b serves as an acceptor for CZ, activated by cleavage by Ci; the complex formed, C4b2a,b is independent of Mg2+ and has ...
Vogt, W., Hinsch, B., Schmidt, G., von Zabern, I.   +3 more
openaire   +2 more sources

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

npj Genomic Medicine, 2022
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, International SSc Group, Susanna M. Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin   +24 more
doaj   +1 more source

The region Ser³³³‐Arg³⁵⁶ of the α‐chain of human C4b‐binding protein is involved in the binding of complement C4b [PDF]

FEBS Letters, 1993
Human C4b‐binding protein (C4BP) functions as a cofactor to factor I in the degradation of C4b and accelerates the decay rate of the C4b2a complex. In this study we describe a monoclonal antibody directed against the α‐chain of C4BP that inhibits the binding of C4b to C4BP.
Hessing, M., Kanters, D., Takeya, H., Veer, C. van 't, Hackeng, T.M., Iwanaga, S., Bouma, B.N.   +6 more
openaire   +2 more sources

Investigation of complement component C4 copy number variation in human longevity. [PDF]

PLoS ONE, 2014
Genetic factors have been estimated to account for about 25% of the variation in an adult's life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences in the overall C4 copy number or
Friederike Flachsbart, Amke Caliebe, Femke-Anouska Heinsen, Tom Hemming-Karlsen, Stefan Schreiber, Andre Franke, Almut Nebel   +6 more
doaj   +1 more source

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)

Lupus Science and Medicine, 2019
Objective Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether ...
Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu   +12 more
doaj   +1 more source

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D.   +22 more
core   +1 more source