Results 41 to 50 of about 16,633 (207)

The Molecular Mechanisms of Complement Receptor 1—It Is Complicated

Biomolecules, 2023
Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on the
Matthew P. Hardy, Mariam Mansour, Tony Rowe, Sandra Wymann   +3 more
doaj   +1 more source

Complement C4A Regulates Autoreactive B Cells in Murine Lupus

Cell Reports, 2020
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll   +6 more
doaj   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Complement C4b-Binding Protein as a Novel Murine Epididymal Secretory Protein [PDF]

Biology of Reproduction, 2003
Complement C4b-binding protein (C4BP) is a plasma protein synthesized in the liver and plays a regulatory role in the host defense complement system. We have previously reported that mRNAs of the C4BP alpha chain (C4BPalpha) are expressed at significant levels in the guinea pig and mouse epididymis in an androgen-dependent manner.
Mayumi I, Nonaka, Yoshitaka, Hishikawa, Nobuo, Moriyama, Takehiko, Koji, Ronald T, Ogata, Akihiko, Kudo, Hayato, Kawakami, Masaru, Nonaka   +7 more
openaire   +2 more sources

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

npj Genomic Medicine, 2022
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, International SSc Group, Susanna M. Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin   +24 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Investigation of complement component C4 copy number variation in human longevity. [PDF]

PLoS ONE, 2014
Genetic factors have been estimated to account for about 25% of the variation in an adult's life span. The complement component C4 with the isotypes C4A and C4B is an effector protein of the immune system, and differences in the overall C4 copy number or
Friederike Flachsbart, Amke Caliebe, Femke-Anouska Heinsen, Tom Hemming-Karlsen, Stefan Schreiber, Andre Franke, Almut Nebel   +6 more
doaj   +1 more source

Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts. [PDF]

, 2017
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of ...
Baumgarth, Nicole, Tracy, Karen E
core   +1 more source

Structural and functional studies of complement inhibitor C4b-binding protein [PDF]

Biochemical Society Transactions, 2002
C4b-binding protein (C4BP) is a potent inhibitor of the classical pathway of the complement system. This large plasma glycoprotein consists of seven identical α-chains and a unique β-chain held together by disulphide bridges. Both types of subunits are composed almost exclusively of complement control protein domains (CCPs).
openaire   +3 more sources

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE)

Lupus Science and Medicine, 2019
Objective Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether ...
Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu   +12 more
doaj   +1 more source