Results 61 to 70 of about 16,633 (207)
The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection [PDF]
, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Ali, Youssif M. +15 more
core +9 more sources
Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus [PDF]
, 1993 We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German ...
Albert, E. D. +6 more
core +1 more source
Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. [PDF]
, 2019 IntroductionLevels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild cognitive impairment (MCI).MethodsParticipants (n = 20 per group) had either MCI ...
Elahi, Fanny M +4 more
core +2 more sources
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
core +1 more source
Novel deletion alleles carrying /chimeric genes in Brazilian patients with 21-hydroxylase deficiency [PDF]
, 2010 Made available in DSpace on 2016-01-24T13:59:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-06-29. Added 1 bitstream(s) on 2016-01-31T13:34:36Z : No.
Araujo, Marcela de +10 more
core +4 more sources
Advanced NanoBiomed Research, EarlyView.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
Freeze-dried plasma proteins are stable at room temperature for at least 1 year
Clinical Proteomics, 2017 Thirty human EDTA plasma samples from male and female subjects ranging in age from 24 to 74 years were collected on ice, processed ice cold and stored frozen at −80 °C, in liquid nitrogen (LN2), or freeze dried and stored at room temperature in a ...
Jaimie Dufresne +5 more
doaj +1 more source
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]
, 2016 Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M. +18 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova +9 more
wiley +1 more source
Frontiers in Immunology, 2019 APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS.
Stephanie L. Savelli +21 more
doaj +1 more source