Results 81 to 90 of about 16,633 (207)
Pathological Roles of Astrocytes in Traumatic Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu +7 more
wiley +1 more source
Islet Amyloid Polypeptide Triggers Limited Complement Activation and Binds Complement Inhibitor C4b-binding Protein, Which Enhances Fibril Formation [PDF]
Journal of Biological Chemistry, 2011 Islet amyloid polypeptide (IAPP) is synthesized in pancreatic β-cells and co-secreted with insulin. Aggregation and formation of IAPP-amyloid play a critical role in β-cell death in type 2 diabetic patients. Because Aβ-fibrils in Alzheimer disease activate the complement system, we have here investigated specific interactions between IAPP and ...
Sjölander, Jonatan +3 more
openaire +4 more sources
REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis
eLife, 2020 The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3 ...
Percy Griffin +7 more
doaj +1 more source
PLoS Pathogens, 2022 The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo +5 more
doaj +1 more source
Spirochetal Lipoproteins and Immune Evasion. [PDF]
, 2017 Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani +2 more
core +1 more source
BMC Medical Genetics, 2008 Background Research indicates that the etiology of autism has a strong genetic component, yet so far the search for genes that contribute to the disorder, including several whole genome scans, has led to few consistent findings.
Odell J Dennis +3 more
doaj +1 more source
Risk Factors for Recurrence of the Anti‐Synthetase Syndrome Related Interstitial Lung Disease
Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.ABSTRACT Purpose This current study aimed to detect the risk factors for recurrence of the anti‐synthetase syndrome related interstitial lung disease (ASSD‐ILD). Methods Patients who were diagnosed with ASSD‐ILD and achieved the improving standards after treatment at a single clinical center from January 1, 2017 to January 1, 2022 were retrospectively ...
Zhen‐Yu Ren +4 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.ABSTRACT Cell recognition and uptake of extracellular vesicles (EVs) is mediated by a variety of surface molecules. Growing interest has recently been drawn towards glycan structures on EVs. Hyaluronic acid (HA) is a negatively charged glycosaminoglycan that can decorate the surface of EVs from different origins.
Heikki Kyykallio +10 more
wiley +1 more source
Functional recruitment of human complement inhibitor C4B-binding protein to outer membrane protein Rck of Salmonella. [PDF]
PLoS ONE, 2011 Resistance to complement mediated killing, or serum resistance, is a common trait of pathogenic bacteria. Rck is a 17 kDa outer membrane protein encoded on the virulence plasmid of Salmonella enterica serovars Typhimurium and Enteritidis.
Derek K Ho +5 more
doaj +1 more source
, 2016 Bursting is a phenomenon found in a variety of physical and biological systems. For example, in neuroscience, bursting is believed to play a key role in the way information is transferred in the nervous system.
Bernard, Christophe +3 more
core +3 more sources