Results 81 to 90 of about 9,987 (203)

Plasma Extracellular Vesicles‐Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Sarcopenia is characterized by progressive loss of muscle mass, strength and physical performance, yet current diagnostic tools are limited for practical and longitudinal monitoring. Extracellular vesicles (EVs) encapsulate various biomolecules, including proteins, nucleic acids, lipids and metabolites and have emerged as promising ...
Ji Yeon Kim, Sung Hye Kong, Dohyun Han, Tae‐Hwan Gil, Hyeon Soo Kim, Miji Kim, Jin Hee Kim, Seung Shin Park, Seong‐Jun Park, Hak Chul Jhang, Chang Won Won, Ok Hee Jeon   +11 more
wiley   +1 more source

Structural basis and functional effects of the interaction between complement inhibitor C4b-binding protein and DNA. [PDF]

, 2008
Human C4b-binding protein (C4BP) is a soluble, multiple-subunit inhibitor of complement that circulates in blood. Recently C4BP was shown to bind DNA, reduce DNA release from necrotic cells and limit DNA-mediated complement activation in solution. Herein
Blom, Anna M, Herbert, Andrew P, Anna M. Blom, Barlow, Paul N, Jenkins, Huw T, Huw T. Jenkins, Marcin Okroj, Paul N. Barlow, Okroj, Marcin,, Andrew P. Herbert, Lund University., Okroj, Marcin   +11 more
core   +1 more source

A Combined Transcriptomics and Proteomics Approach to Identify Immune Signatures in ANCA‐Associated Glomerulonephritis

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis often leads to severe kidney damage. To better understand ANCA‐associated glomerulonephritis (AAGN) and identify potential new therapeutic targets, we performed comprehensive transcriptomic and compartmental proteomic analysis of kidney biopsies from 23 patients in the ...
Ivana Stojkic, John P. Shapiro, Arnon Arazi, Huijuan Song, Pearlly Yan, Estela Puchulu‐Campanella, Hubao Wang, William E. Smoyer, Lynn A. Fussner, Anjali Satoskar, Xin Wang, Samir V. Parikh, Stacy P. Ardoin, Dan Koboldt, Brad H. Rovin, Salem Almaani   +15 more
wiley   +1 more source

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]

, 2007
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Brown, JS, Brown, J.S., Yuste, J., Botto, M., Bottoms, SE, Bottoms, S.E., Yuste, J, Botto, M   +7 more
core  

Functional recruitment of human complement inhibitor C4B-binding protein to outer membrane protein Rck of Salmonella. [PDF]

PLoS ONE, 2011
Resistance to complement mediated killing, or serum resistance, is a common trait of pathogenic bacteria. Rck is a 17 kDa outer membrane protein encoded on the virulence plasmid of Salmonella enterica serovars Typhimurium and Enteritidis.
Derek K Ho, Jorma Tissari, Hanna M Järvinen, Anna M Blom, Seppo Meri, Hanna Jarva   +5 more
doaj   +1 more source

Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1292-1301, July 2026.
This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo, Ziheng Yan, Jingyu Ye, Ruifu Yang, Yajun Song, Hui Yue, Yong Zhao   +6 more
wiley   +1 more source

C4b-Binding Protein [PDF]

, 2017
C4b-binding protein (C4BP) is the main fluid-phase inhibitor of the classical complement pathway. It serves as cofactor in factor I-mediated cleavage of C4b and C3b and it accelerates the decay of complement convertases.
Blom, Anna M., Okrój, Marcin, Anna M. Blom, Marcin Okrój   +3 more
core   +1 more source

Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial

Arthritis &Rheumatology, Volume 78, Issue 7, Page 1403-1413, July 2026.
Objective Our study objective was to identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA (Arthritis Prevention In the Preclinical Phase of RA with Abatacept) study participants were selected from baseline to RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source