Results 101 to 110 of about 16,633 (207)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

Journal of Biological Chemistry, 1990
C4b-binding protein (C4BP) is a large complex assembly of eight subunits that functions as an inhibitor of the complement cascade. A portion of the C4BP in serum exists as a complex with protein S. This study demonstrated that another protein, serum amyloid P component (SAP), also formed a calcium-dependent complex with C4BP.
R A, Schwalbe, B, Dahlbäck, G L, Nelsestuen   +2 more
openaire   +2 more sources

The region Ser³³³‐Arg³⁵⁶ of the α‐chain of human C4b‐binding protein is involved in the binding of complement C4b [PDF]

FEBS Letters, 1993
Human C4b‐binding protein (C4BP) functions as a cofactor to factor I in the degradation of C4b and accelerates the decay rate of the C4b2a complex. In this study we describe a monoclonal antibody directed against the α‐chain of C4BP that inhibits the binding of C4b to C4BP.
Hessing, M., Kanters, D., Takeya, H., Veer, C. van 't, Hackeng, T.M., Iwanaga, S., Bouma, B.N.   +6 more
openaire   +2 more sources

The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
Both transient ischaemic attack (TIA) and ischaemic stroke lead to an increase in individual cellular‐derived populations of extracellular vesicles (EVs), including endothelial, platelet and leukocyte derived. These EVs have downstream roles in the pathophysiological events associated with TIA and stroke, including dysregulated inflammation and ...
Rebecca Marie Raven, Philip Eurig James, Keith Morris, Jessica Olivia Williams   +3 more
wiley   +1 more source

Structure of Complement Component C2a: Implications for Convertase Formation and Substrate Binding [PDF]

, 1906
SummaryC2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal structures of full-length C2a, with and without a pseudo ligand bound.
Fin J. Milder, Hans C.A. Raaijmakers, Mitja D.A.A. Vandeputte, Arie Schouten, Eric G. Huizinga, Roland A. Romijn, Wieger Hemrika, Anja Roos, Mohamed R. Daha, Piet Gros, Barash, Bentley, Bhattacharya, Bode, Brunger, Crump, Durocher, Emsley, Emsley, Fredslund, Graham, Hinshelwood, Horiuchi, Janssen, Jin, Jing, Jones, Kallen, Kam, Kerr, Kerr, Khan, Leslie, Murshudov, Palmiter, Pangburn, Perona, Ponnuraj, Rawal, Roos, Shimaoka, Song, Storoni, Tomana, Walport, Walport, Wattanasin, Winn   +47 more
core   +1 more source

Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity.

The Journal of biological chemistry, 2003
We identified Neisseria meningitidis lipooligosaccharide (LOS) as an acceptor for complement component C4b (C4b). Phosphoethanolamine (PEA) residues on the second heptose (HepII) residue in the LOS core structure formed amide linkages with C4b. PEA at the 6-position of HepII (6-PEA) was more efficient than 3-PEA in binding C4b.
Seppo Meri, J. Claire Wright, Peter A. Rice, Sunita Gulati, Sanjay Ram, Ulrich Vogel, Daniel C. Stein, E. Richard Moxon, Ryan Boden, Andrew D. Cox, Silke Getzlaff, James C. Richards, Jianjun Li, Joyce S. Plested   +13 more
openaire   +3 more sources

Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion

BMC Ophthalmology
Background Retinal vein occlusion (RVO) is a major cause of vision loss. The pathogenesis remains poorly defined although inflammation is known to play a critical role.
Hengwei Liu, Yufan Zhou, Jinyan Qi, Shengnan Liang, Tingting Guo, Juan Chen, Huanhuan Tan, Jie Wang, Heping Xu, Zhongping Chen   +9 more
doaj   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, Volume 13, Issue 8, 9 February 2026.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Membranoproliferative glomerulonephritis in patients with chronic venous catheters: a case report and literature review. [PDF]

, 2014
Chronic indwelling catheters have been reported to be associated with membranoproliferative glomerulonephritis (MPGN) via the activation of the classical complement pathway in association with bacterial infections such as coagulase negative ...
Nast, Cynthia C, Pham, Phuong-Chi T, Pham, Phuong-Thu T, Sy, John   +3 more
core   +2 more sources

Proteomic analysis of human plasma in chronic rheumatic mitral stenosis reveals proteins involved in the complement and coagulation cascade [PDF]

, 2014
BACKGROUND: Rheumatic fever in childhood is the most common cause of Mitral Stenosis in developing countries. The disease is characterized by damaged and deformed mitral valves predisposing them to scarring and narrowing (stenosis) that results in left ...
Arun Bandyopadhyay, Mahesh J Kulkarni, Mashanipalya G Jagadeeshaprasad, Monodeep Biswas, Sanjib Pattari, Santanu Dutta, Somaditya Mukherjee, Sudip K Ghosh, Tanima Banerjee   +8 more
core   +1 more source