Results 101 to 110 of about 9,987 (203)

Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed, Yilin Wang, Yangping Li, Guoku Hu, Jingjing Yang, Bing Yao, Andrew Escayg   +6 more
wiley   +1 more source

Consumption of C4b-binding protein (C4BP) during in vivo activation of the classical complement pathway [PDF]

, 1999
C4BP has a central role in regulating the classical complement (C') pathway, but it is still uncertain whether or not it is consumed during in vivo complement activation.
M. Cicardi, A. Miedico, R. Coppola, A. Agostoni, L. Bergamaschini, E. N. Faioni   +5 more
core   +1 more source

Synthesis, Photophysical Characterization, and Anticancer Evaluation of Novel Furochromene Derivatives

ChemistryOpen, Volume 15, Issue 6, June 2026.
This is the first study on novel furochromene derivatives. A series of novel furochromen derivatives, namely (2E)‐1‐(6‐hydroxy‐4,7‐dimethoxy‐1‐benzofuran‐5‐yl)‐3‐arylprop‐2‐en‐1‐ones 4a–c, were synthesized via the Knoevenagel condensation of 6‐hydroxy‐4,7‐dimethoxybenzofuran‐5‐ylethanone 2 with various aromatic aldehydes.
Amal Rabahi, Mustapha Mounir Bouhenna, Hasnia Abdeldjebar, Massinissa Baymout, Malika Makhloufi‐Chebli, Walter Luyten, Hamdi Bendif, Anis Ahmad Chaudhary, Walid Elfalleh, Stefania Garzoli   +9 more
wiley   +1 more source

Hydralazine binds covalently to complement component-C4: Different reactivity of C4A AND C4B Gene-Products [PDF]

, 1985
Long-term treatment with hydralazine is sometimes associated with deposition of immune complexes and development of systemic lupus erythematosus (SLE) as an adverse side-effect. Hydralazine inhibits the covalent binding reaction of the complement protein
Law, Sai-Kit A., Edith Sim, Sim, Edith, Sai-Kit A. Law   +3 more
core   +1 more source

Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion

BMC Ophthalmology
Background Retinal vein occlusion (RVO) is a major cause of vision loss. The pathogenesis remains poorly defined although inflammation is known to play a critical role.
Hengwei Liu, Yufan Zhou, Jinyan Qi, Shengnan Liang, Tingting Guo, Juan Chen, Huanhuan Tan, Jie Wang, Heping Xu, Zhongping Chen   +9 more
doaj   +1 more source

Urine Proteomic Profiling at Admission Reveals Complement Biomarkers Linked to Alcohol‐Associated Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
Patients with alcohol‐associated hepatitis (AH) and alcohol‐cirrhosis (AC) show perturbations in complement. Complement activation pathways are perturbed in the urine of patients with AH and AC, and distinguish severe AH from AC. Complement perturbations can help physicians and researchers to understand the liver–kidney crosstalk in severe AH and AC ...
Luan Prado, Ryan Musich, Moyinoluwa Taiwo, Vai Pathak, Daniel M. Rotroff, Annette Bellar, Nicole Welch, Jaividhya Dasarathy, David Streem, for the AlcHepNet, Srinivasan Dasarathy, Laura E. Nagy   +11 more
wiley   +1 more source

Intracellular degradation of the complement C3b/C4b receptor in the absence of ligand.

Journal of Biological Chemistry, 1988
Human neutrophils (PMN) respond to various soluble stimuli by translocating intracellular complement C3b/C4b receptors (CR1) to the cell surface. Ligand-independent internalization of surface CR1 has been demonstrated previously, but the fate of total cellular CR1 during PMN stimulation has not been determined.
J R, Turner, A M, Tartakoff, M, Berger
openaire   +2 more sources

Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom [PDF]

, 2010
Atypical haemolytic uraemic syndrome (aHUS) is associated with a poor prognosis with regard to survival at presentation, recovery of renal function and transplantation.
Sam Machin, ?, ?, Machin, Sam, Tim H. J. Goodship, Goodship, Tim H J, Stephen J. Wigmore, Taylor, C Mark, Wigmore, Stephen J, C. Mark Taylor   +8 more
core   +1 more source

Self-association of complement factor H in the presence and absence of metals [PDF]

, 2010
In the complement system of innate immunity, factor H (FH) is a major regulator of its activation, and is comprised of 20 short complement regulator (SCR) domains.
Nan, R.
core  

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source