Expression of the ß-chain of the complement regulator C4b-binding protein in human ovary
European Journal of Cell Biology, 1999 Human C4b-binding protein (C4BP) is an important regulator of the complement system that also binds and inactivates the anticoagulant vitamin K-dependent protein S. These two activities are performed by two distinct polypeptides of 70 kDa and 45 kDa known as alpha and beta chains, respectively.
Criado-García, Olga +4 more
openaire +3 more sources
Vitamin k-dependent protein s localizing complement regulator c4b-binding protein to the surface of apoptotic cells. [PDF]
, 2002 Apoptosis is characterized by a lack of inflammatory reaction in surrounding tissues, suggesting local control of complement activation. During the initial stage of apoptosis, cells expose negatively charged phospholipid phosphatidylserine on their ...
Dahlbäck, Björn +5 more
core +1 more source
Complement Factor H: solution structures and interactions with ligands [PDF]
, 2009 Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core
PLoS ONE, 2012 Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ...
Patience B Tetteh-Quarcoo +9 more
doaj +1 more source
Complement-mediated adherence of immune complexes to human erythrocytes Difference in the requirements for C4A and C4B [PDF]
, 1987 The classical pathway of complement is required for the adherence of soluble tetanus toxoid (TT)-human anti-TT complexes to erythrocytes. Using human C4-deficient serum we compared the capacity of the two forms of human C4 (C4A and C4B) to mediate this ...
Jean-Pierre Paccaud +5 more
core +1 more source
The surface protease PgtE of Salmonella enterica affects complement activity by proteolytically cleaving C3b, C4b and C5 [PDF]
, 2007 Complement activity in mammalian serum is fundamentally based on three homologous components C3b, C4b and C5. During systemic infection, the gastrointestinal pathogen Salmonella enterica disseminates within host phagocytic cells but also extracellularly.
Holmberg, Mikko +11 more
core +1 more source
Pentraxins in Complement Activation and Regulation
Frontiers in Immunology, 2018 The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self
Ying Jie Ma, Peter Garred
doaj +1 more source
Association between copy number variation of complement component
Journal of Biomedical Science, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling +7 more
doaj +1 more source
The hyphal and yeast forms of Candida albicans bind the complement regulator C4b-binding [PDF]
, 2004 Candida albicans, an important pathogenic yeast, activates all three pathways of the complement system. To understand how this yeast evades the effects of the activated system, we have analyzed the binding of the classical pathway inhibitor C4b-binding ...
Meri, S +13 more
core +1 more source
Complement proteins changes in ischemic stroke patients and their relation to outcome
ImmunobiologyWe studied plasma levels of complement system factors C1q, C2, C3, C3b, C4, C4b, C5, C5a, C9 of 84 patients with ischemic stroke within 24 h from onset of symptoms and on seventh day after admission, using Luminex immunoassay.
Radosław Opiła +5 more
doaj +1 more source