Results 91 to 100 of about 16,633 (207)

The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation [PDF]

, 2016
Parasitic nematodes manufacture various carbohydratelinked phosphorylcholine (PCh)-containing molecules, including ES-62, a protein with an N-linked glycan terminally substituted with PCh.
Ahmed, Umul Kulthum, Al-Riyami, Lamyaa, Harnett, William, Iqbal, Asif J., Maller, N. Claire, Raynes, John G.   +5 more
core   +1 more source

Increased frequency of the null allele at the complement C4b locus in autism [PDF]

Clinical and Experimental Immunology, 1991
SUMMARY Associations between C4 deficiency and autoimmune disorders have been found over the past several years. Since autism has several autoimmune features, the frequencies of null (no protein produced) alleles at the C4A and C4B loci were studied in 19 subjects with autism and their family members.
R P, Warren, V K, Singh, P, Cole, J D, Odell, C B, Pingree, W L, Warren, E, White   +6 more
openaire   +2 more sources

Neoadjuvant Therapy‐Induced Remodeling in Pancreatic Ductal Adenocarcinoma: Multimodal Spatial Analysis and Prognosis

Cancer Science, Volume 117, Issue 4, Page 1167-1177, April 2026.
Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang, Ruoxin Lan, Danting Li, Yongjun Liu, Sonu Kalyan, Momin Iqbal, Nancy Liu, Jerry Zhang, Iman Hanna, Mala Gupta, Chaohui L. Zhao, Weiguo Liu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao‐Zhong Liu   +16 more
wiley   +1 more source

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. [PDF]

Proceedings of the National Academy of Sciences, 1983
C4b-binding protein (C4bp) participates in the regulation of the C3 convertase of the classical pathway of complement. By binding to C4b, which is one of the structural subunits of this enzyme, C4bp accelerates the decay-dissociation of the enzyme and renders C4b susceptible to degradation by factor I (C3b inactivator).
B, Dahlbäck, C A, Smith, H J, Müller-Eberhard   +2 more
openaire   +2 more sources

Manin's conjecture for a class of singular cubic hypersurfaces

, 2017
Let $n$ be a positive multiple of $4$. We establish an asymptotic formula for the number of rational points of bounded height on singular cubic hypersurfaces $S_n$ defined by $$ x^3=(y_1^2 + \cdots + y_n^2)z . $$ This result is new in two aspects: first,
Liu, Jianya, Wu, Jie, Zhao, Yongqiang
core   +1 more source

Identification of Key Genes Involved in Lactic Acid Metabolism in Periodontitis Based on Bioinformatics Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Lactic acid metabolism correlates with periodontitis progression. Using machine learning (LASSO and SVM‐RFE) on GSE16134 and GSE173078 datasets, CFI and COQ2 were identified as key genes, with good diagnostic performance (AUC > 0.75). GSEA linked these genes to MAPK signalling, endocytosis, and ubiquitin‐mediated proteolysis.
Bijun Zhu, Shi Xu, Mingyue Cheng, Leiying Miao   +3 more
wiley   +1 more source

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Haematologica, 2019
High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA antibodies.
Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +14 more
doaj   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +2 more sources

A Dual‐Phase Approach to Facial Rejuvenation Integrating Contouring and Ligamentous (CL Code) Anchoring With a Polycaprolactone‐Based Collagen Stimulator

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Facial aging reflects concurrent skeletal remodeling, fat redistribution, and attenuation of retaining ligaments. Volume‐oriented fillers may restore contours but often underaddress structural support. Objective To describe the CL Code, a dual‐phase injectable protocol combining Contouring (C) and Ligamentous anchoring (L), using a ...
Gi‐Woong Hong, Isaac Kai Jie Wong, Jovian Wan, Soo Yeon Park, Suyeon Lee, Kyu‐Ho Yi   +5 more
wiley   +1 more source

How Escherichia coli Circumvent Complement-Mediated Killing

Frontiers in Immunology, 2017
Complement is a crucial arm of the innate immune response against invading bacterial pathogens, and one of its main functions is to recognize and destroy target cells.
Angela S. Barbosa, Afonso G. Abreu, Afonso G. Abreu   +2 more
doaj   +1 more source