Results 71 to 80 of about 9,987 (203)

and the Human Complement Regulator C4b-Binding Protein [PDF]

, 2001
C4b-binding protein (C4BP) is an important plasma inhibitor of the classical pathway of complement activation. Several bacterial pathogens bind C4BP, which may contribute to their virulence. In the present report we demonstrate that isolated type IV pili
Lindahl, G, Anna M. Blom, Gunnar Lindahl, Björn Dahlbäck, Vasquez, P, Dahlbäck, B, Blom, AM, Rytkönen, A, Paola Vasquez, Jonsson, AB, Anne Rytkönen, Ann-Beth Jonsson   +11 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

eLife, 2020
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3 ...
Percy Griffin, Patrick W Sheehan, Julie M Dimitry, Chun Guo, Michael F Kanan, Jiyeon Lee, Jinsong Zhang, Erik S Musiek   +7 more
doaj   +1 more source

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source

Genomic Copy Number Variations of the Complement Component C4B Gene Are Associated With Chronic Central Serous Chorioretinopathy [PDF]

, 2015
Contains fulltext : 155364.pdf (Publisher’s version ) (Open Access)PURPOSE: Chronic central serous chorioretinopathy (cCSC) has recently been associated to variants in the complement factor H gene. To further investigate the role of the
Jong, E.K. de, Breukink, M.B., Schellevis, R.L., Boon, C.J.F., Fauser, S., Hoyng, C.B., Hollander, A.I. den   +6 more
core   +1 more source

DataSheet_1_Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases.docx [PDF]

, 2021
Human complement C4 is one of the most diverse but heritable effectors for humoral immunity. To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including ...
Werner Passler (11607298), Wael N. Jarjour (7871042), Gilbert T. Chua (9236639), Stacy P. Ardoin (6669185), Joanne L. Drew (11607286), Daniel J. Birmingham (11607295), Michael Rudnicki (135332), Simon K. Lawrance (11607283), Bi Zhou (10981806), Chi Chiu Mok (8711049), Chack Yung Yu (9355063), Sasigarn A. Bowden (11607304), Yu Lung Lau (9018290), Yee Ling Wu (6669188), Miranda E. Hilt (11607292), Danlei Zhou (6669173), Jeffrey J. Auletta (11607301), Fatima Barbar-Smiley (6669182), Robert P. Hoffman (11607307), Taylor K. Armstrong (11607289)   +19 more
core   +1 more source

Identification of Prognostic Genes Relevant With the Nuclear Factors of Activated T Cells Based on Transcriptomics in Oral Squamous Cell Carcinoma

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Background It has previously been demonstrated that the nuclear factor of activated T cells (NFAT) is crucial for the development of tumors. Given OSCC's drug resistance and poor outcomes, identifying NFAT‐associated prognostic genes is urgent for better treatment.
Julaiti Tuerxun, Ailimaierdan Ainiwaer, Tairan Ding   +2 more
wiley   +1 more source

Enolase of Streptococcus pneumoniae Binds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion. [PDF]

, 2012
Streptococcus pneumoniae (pneumococcus) is a pathogen that causes severe local and life-threatening invasive diseases, which are associated with high mortality rates.
Hammerschmidt, Sven, Blom, Anna, Vaibhav Agarwal, Anna M. Blom, Sven Malm, Sven Hammerschmidt, Simone Bergmann, Agarwal, Vaibhav, Bergmann, Simone, Riesbeck, Kristian, Kristian Riesbeck, Malm, Sven   +11 more
core   +1 more source

C4B null alleles are not associated with genetic polymorphisms in the adjacent gene CYP21A2 in autism

BMC Medical Genetics, 2008
Background Research indicates that the etiology of autism has a strong genetic component, yet so far the search for genes that contribute to the disorder, including several whole genome scans, has led to few consistent findings.
Odell J Dennis, Odell Daniel W, Sweeten Thayne L, Torres Anthony R   +3 more
doaj   +1 more source