Results 51 to 60 of about 9,987 (203)

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +1 more source

Kinetic Analysis of the Interactions between Vaccinia Virus Complement Control Protein and Human Complement Proteins C3b and C4b [PDF]

, 2004
The vaccinia virus complement control protein (VCP) is an immune evasion protein of vaccinia virus. Previously, VCP has been shown to bind and support inactivation of host complement proteins C3b and C4b and to protect the vaccinia virions from antibody ...
Bernet, John, Mullick, Jayati, Panse, Yogesh, Sahu, Arvind, Parab, Pradeep B.   +4 more
core   +1 more source

The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients

Intensive Care Medicine Experimental, 2020
Background Mechanical ventilation can induce or even worsen lung injury, at least in part via overdistension caused by too large volumes or too high pressures.
Friso M. de Beer, Luuk Wieske, Gerard van Mierlo, Diana Wouters, Sacha Zeerleder, Lieuwe D. Bos, Nicole P. Juffermans, Marcus J. Schultz, Tom van der Poll, Wim K. Lagrand, Janneke Horn, for the BASIC–study group   +11 more
doaj   +1 more source

Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism [PDF]

, 2016
During the activation of complement C4 to C4b, the exposure of its thioester domain (TED) is crucial for the attachment of C4b to activator surfaces. In the C4b crystal structure, TED forms an Arg(104)-Glu(1032) salt bridge to tether its neighbouring ...
Jayesh Gor, Swann, MJ, David W. Wright, Marcus J. Swann, Gor, J, Ka Wai Fung, Wright, DW, Fung, KW, Stephen J. Perkins, Perkins, SJ   +9 more
core   +1 more source

SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

Frontiers in Immunology, 2022
Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination.
Rachel E. Lamerton, Rachel E. Lamerton, Edith Marcial-Juarez, Sian E. Faustini, Marisol Perez-Toledo, Margaret Goodall, Siân E. Jossi, Maddy L. Newby, Iain Chapple, Thomas Dietrich, Tonny Veenith, Adrian M. Shields, Lorraine Harper, Ian R. Henderson, Julie Rayes, David C. Wraith, Steve P. Watson, Max Crispin, Mark T. Drayson, Alex G. Richter, Adam F. Cunningham   +20 more
doaj   +1 more source

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase [PDF]

, 2020
The classical and lectin pathways of the complement system are important for the elimination of pathogens and apoptotic cells and stimulation of the adaptive immune system.
Zarantonello, Alessandra, Andersen, Gregers R., Yalcin, Esra, Thiel, Steffen, Presumey, Jessy, Carroll, Michael C., Olesen, Heidi Gytz, Johnson, Matthew B., Hansen, Annette, Stevens, Beth, Simoni, Léa, Fox, Rachel, Laursen, Nick Stub   +12 more
core   +1 more source

Evidence that a nicked C4b, C4b′, is a functionally active C4b derivative [PDF]

, 1986
Factor I-catalyzed C4b cleavage is a regulatory reaction for the classical pathway of the complement system. Although the reaction was shown to be a two-step reaction, (i) production of a nicked form of C4b, C4b′, as an intermediate cleavage product and (
Ichihara, Chikako, Chikako Ichihara, Mina Yamazaki, Shigeharu Nagasawa, Yamazaki, Mina, Nagasawa, Shigeharu   +5 more
core   +1 more source

Complement C4b-Binding Protein as a Novel Murine Epididymal Secretory Protein [PDF]

Biology of Reproduction, 2003
Complement C4b-binding protein (C4BP) is a plasma protein synthesized in the liver and plays a regulatory role in the host defense complement system. We have previously reported that mRNAs of the C4BP alpha chain (C4BPalpha) are expressed at significant levels in the guinea pig and mouse epididymis in an androgen-dependent manner.
Mayumi I, Nonaka, Yoshitaka, Hishikawa, Nobuo, Moriyama, Takehiko, Koji, Ronald T, Ogata, Akihiko, Kudo, Hayato, Kawakami, Masaru, Nonaka   +7 more
openaire   +2 more sources

Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation [PDF]

, 2011
The complement system plays a pivotal protective role in the innate immune response to many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted nonstructural glycoprotein that accumulates in plasma to high levels and ...
Blom, Anna,, Anna M. Blom, Diamond, Michael S., Panisadee Avirutnan, Somnuke, Pawit, Atkinson, John P., Blom, Anna, John P. Atkinson, Michael S. Diamond, Hauhart, Richard E., Pawit Somnuke, Lund University., Richard E. Hauhart, Avirutnan, Panisadee   +13 more
core   +1 more source

Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow

Advanced Materials Interfaces, EarlyView.
A biomimetic venous circulation system is developed to study protein corona formation on soft nanocarriers under physiological shear. Liposomes, PLGA nanoparticles, and lipid‐polymer hybrid nanoparticles acquire largely shared but material‐dependent protein coronas that alter surface properties and suppress cellular uptake, highlighting the importance ...
Anamarija Nikoletić, Dominik Simon Müller, Timon Flathmann, Jakob Steuer, Evangelos Natsaridis, Chiara Candino, Abdullah Kahraman, Oya Tagit   +7 more
wiley   +1 more source