Results 21 to 30 of about 16,633 (207)

Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes

Frontiers in Cellular Neuroscience, 2023
Complement system plays an important role in the immune defense against pathogens; however, recent studies demonstrated an important role of complement subunits C1q, C4, and C3 in normal functions of the central nervous system (CNS) such as non ...
Tatyana Veremeyko, Tatyana Veremeyko, Tatyana Veremeyko, Rongcai Jiang, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev, Eugene D. Ponomarev, Eugene D. Ponomarev   +8 more
doaj   +1 more source

Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia. [PDF]

PLoS ONE, 2012
Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis.
Sven Malm, Monika Jusko, Sigrun Eick, Jan Potempa, Kristian Riesbeck, Anna M Blom   +5 more
doaj   +1 more source

Increased frequency of complement C4B deficiency in rheumatoid arthritis. [PDF]

Arthritis Rheum, 2012
AbstractObjectiveTo assess the copy number variation of complement C4A and C4B genes in patients with rheumatoid arthritis (RA).MethodsDNA samples were obtained from 299 patients and controls and analyzed for copy number variation of total complement C4, C4A, and C4B genes. The results were compared by chi‐square analysis, and odds ratios (ORs) and 95%
Rigby WF, Wu YL, Zan M, Zhou B, Rosengren S, Carlson C, Hilton W, Yu CY.   +7 more
europepmc   +4 more sources

Complement c4b–null alleles in felty's syndrome [PDF]

Arthritis & Rheumatism, 1988
AbstractC4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA–DR4. A C4B‐null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%).
W, Thomson, P A, Sanders, M, Davis, J, Davidson, P A, Dyer, D M, Grennan   +5 more
openaire   +2 more sources

The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35) [PDF]

The Journal of Immunology, 2004
AbstractSeveral previous reports concluded that the C4b fragment of human C4A (C4Ab) binds with higher affinity to CR1 than does C4Bb. Because the isotypic residues, 1101PCPVLD and 1101LSPVIH in C4A and C4B, respectively, are located within the C4d region, one may have expected a direct binding contribution of C4d to the interaction with CR1.
Liliana, Clemenza, David E, Isenman
openaire   +4 more sources

Synovial Complement Factors in Patients with Periprosthetic Joint Infection after Undergoing Revision Arthroplasty of the Hip or Knee Joint

Diagnostics, 2021
The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen, Sophia Schell, Matthias Dominik Wimmer, Gunnar Thorben Rembert Hischebeth, Hendrik Kohlhof, Sascha Gravius, Thomas Martin Randau   +6 more
doaj   +1 more source

Exploring the function of factor XIII free B subunit: Interactions with complement factors and a novel approach to identify potential binding partners

Research and Practice in Thrombosis and Haemostasis, 2022
Background The factor XIII (FXIII)‐B subunit has a critical function as a carrier protein to stabilize FXIII‐A in plasma and supply it to its main substrate, fibrinogen.
Bojun Li, Clément Bechtler, Lorenz Jenny, Daniel Ricklin, Verena Schroeder   +4 more
doaj   +1 more source

CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage

Frontiers in Immunology, 2022
Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries, Marie Heß, Noura Nouri, Thomas A. Wichelhaus, Stephan Göttig, Franco H. Falcone, Peter Kraiczy   +6 more
doaj   +1 more source

Expression of Human Thrombomodulin Prevents Early Thrombocytopenia and Thrombotic Microangiopathy in Pig-to-Nonhuman Primate Orthotopic Liver Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhang Z, Li T, Li Q, Xie B, Zhao X, Wang J, Huang Y, Luo J, Wen S, Zhou Y, Deng Y, Lu Y, Jiang Y, Li J, Cooper DKC, Pan D, Si Z, Qi H.   +17 more
europepmc   +2 more sources

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity. [PDF]

FEBS J
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Pinto AJ, Chouquet A, Bally I, Rossi V, Thielens NM, Dumestre-Pérard C, Kunert R, Gaboriaud C, Ling WL, Reiser JB.   +9 more
europepmc   +2 more sources