Results 21 to 30 of about 9,987 (203)
Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein. [PDF]
PLoS Pathogens, 2008 Many pathogens are equipped with factors providing resistance against the bactericidal action of complement. Yersinia enterocolitica, a Gram-negative enteric pathogen with invasive properties, efficiently resists the deleterious action of human ...
Vesa Kirjavainen +5 more
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Human pentraxin 3 binds to the complement regulator c4b-binding protein.
PLoS ONE, 2011 The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells.
Anne Braunschweig, Mihály Józsi
doaj +4 more sources
Significance of urine complement proteins in monitoring lupus activity [PDF]
PeerJ, 2022 Objectives Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported.
Jin Zhao +5 more
doaj +2 more sources
Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus
Viruses, 2021 Adenovirus (AdV) infection elicits a strong immune response with the production of neutralizing antibodies and opsonization by complement and coagulation factors.
Corey C. Emerson, Phoebe L. Stewart
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Frontiers in Cellular Neuroscience, 2023 Complement system plays an important role in the immune defense against pathogens; however, recent studies demonstrated an important role of complement subunits C1q, C4, and C3 in normal functions of the central nervous system (CNS) such as non ...
Tatyana Veremeyko +8 more
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Increased frequency of complement C4B deficiency in rheumatoid arthritis. [PDF]
Arthritis Rheum, 2012 AbstractObjectiveTo assess the copy number variation of complement C4A and C4B genes in patients with rheumatoid arthritis (RA).MethodsDNA samples were obtained from 299 patients and controls and analyzed for copy number variation of total complement C4, C4A, and C4B genes. The results were compared by chi‐square analysis, and odds ratios (ORs) and 95%
Rigby WF +7 more
europepmc +4 more sources
The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35) [PDF]
The Journal of Immunology, 2004 Abstract Several previous reports concluded that the C4b fragment of human C4A (C4Ab) binds with higher affinity to CR1 than does C4Bb. Because the isotypic residues, 1101PCPVLD and 1101LSPVIH in C4A and C4B, respectively, are located within the C4d region, one may have expected a direct binding contribution of C4d to the interaction ...
Clemenza, Liliana, Isenman, David E.
openaire +5 more sources
Complement c4b–null alleles in felty's syndrome [PDF]
Arthritis & Rheumatism, 1988 AbstractC4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA–DR4. A C4B‐null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%).
W, Thomson +5 more
openaire +2 more sources
Diagnostics, 2021 The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen +6 more
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Research and Practice in Thrombosis and Haemostasis, 2022 Background The factor XIII (FXIII)‐B subunit has a critical function as a carrier protein to stabilize FXIII‐A in plasma and supply it to its main substrate, fibrinogen.
Bojun Li +4 more
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