Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP [PDF]
Molecular and Cellular ProteomicsC4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalently bind vitamin K-dependent protein S (ProS). These spider-like structures can form even larger complexes as C4BP interacts with other, mostly complement ...
Johannes Preiner +2 more
exaly +4 more sources
Multifaceted Activities of Seven Nanobodies against Complement C4b. [PDF]
J Immunol, 2022 Abstract Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation of C4 and other initial components of the classical pathway may cause or aggravate pathologies, such as ...
De la O Becerra KI +9 more
europepmc +6 more sources
Real-time PCR quantification of human complement C4A and C4B genes [PDF]
BMC Genetics, 2006 Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George +5 more
doaj +3 more sources
Clinical features of patients with homozygous complement C4A or C4B deficiency.
PLoS ONE, 2018 IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa +4 more
doaj +4 more sources
Structural insights into C3 convertase activity of the classical pathway of complement [PDF]
Nature CommunicationsImmune protection by the complement system depends on C3 cleavage by C3 convertases that is critical to all three activation pathways. Structural data on convertase formation in the classical pathway and on C3-substrate binding to convertases is lacking.
Karla I. De la O Becerra +3 more
doaj +2 more sources
Human pentraxin 3 binds to the complement regulator c4b-binding protein.
PLoS ONE, 2011 The long pentraxin 3 (PTX3) is a soluble recognition molecule with multiple functions including innate immune defense against certain microbes and the clearance of apoptotic cells.
Anne Braunschweig, Mihály Józsi
doaj +4 more sources
The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface [PDF]
Infection and Immunity, 2019 Youssif M Ali +2 more
exaly +2 more sources
Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes. [PDF]
Arthritis RheumatolObjective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. The variable copy number (CN) of C4 genes and retroviral human endogenous retrovirus K (HERV‐K) element influence its function.
Martínez-López J +24 more
europepmc +2 more sources
Significance of urine complement proteins in monitoring lupus activity [PDF]
PeerJ, 2022 Objectives Complement activation is a critical feature in the development of systemic lupus erythematosus (SLE). Whether there are changes of complement components in the urine of SLE has not been reported.
Jin Zhao +5 more
doaj +2 more sources
Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus
Viruses, 2021 Adenovirus (AdV) infection elicits a strong immune response with the production of neutralizing antibodies and opsonization by complement and coagulation factors.
Corey C. Emerson, Phoebe L. Stewart
doaj +1 more source