Multifaceted Activities of Seven Nanobodies against Complement C4b. [PDF]
J Immunol, 2022 Abstract Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and lectin pathways of the complement system. Dysregulated activation of C4 and other initial components of the classical pathway may cause or aggravate pathologies, such as ...
De la O Becerra KI +9 more
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Clinical features of patients with homozygous complement C4A or C4B deficiency. [PDF]
PLoS ONE, 2018 IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa +4 more
doaj +5 more sources
Real-time PCR quantification of human complement C4A and C4B genes [PDF]
BMC Genetics, 2006 Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George +5 more
doaj +5 more sources
Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia. [PDF]
PLoS ONE, 2012 Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis.
Sven Malm +5 more
doaj +4 more sources
Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]
PLoS ONE, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab +7 more
doaj +3 more sources
Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae [PDF]
Infection and Immunity, 2008 ABSTRACTComplement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide onNeisseria meningitidisas an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization
Lewis, Lisa A. +7 more
openaire +5 more sources
Structural and functional studies of complement inhibitor C4b-binding protein [PDF]
Biochemical Society Transactions, 2002 C4b-binding protein (C4BP) is a potent inhibitor of the classical pathway of the complement system. This large plasma glycoprotein consists of seven identical α-chains and a unique β-chain held together by disulphide bridges. Both types of subunits are composed almost exclusively of complement control protein domains (CCPs).
Blom, Anna
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Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP [PDF]
Molecular and Cellular ProteomicsC4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalently bind vitamin K-dependent protein S (ProS). These spider-like structures can form even larger complexes as C4BP interacts with other, mostly complement ...
Leendert Trouw +2 more
exaly +6 more sources
Importance of the α3‐fragment of complement C4 for the binding with C4b‐binding protein [PDF]
FEBS Letters, 1990 The human regulatory complement component C4b‐binding protein (C4BP) is a multimene plasma protein, which regulates the classical pathway of the complement system. C4BP functions as a cofactor to factor 1 in the degradation of C4b and accelerates the decay rate of the C4b2a complex.
Hessing, M. +4 more
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Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli [PDF]
Kidney International, 1986 Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Feucht, Helmut E. +7 more
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