Complement C4A Regulates Autoreactive B Cells in Murine Lupus [PDF]
Cell Reports, 2020 Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Jessy Presumey +2 more
exaly +4 more sources
Clinical features of patients with homozygous complement C4A or C4B deficiency [PDF]
PLoS ONE, 2018 IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa +2 more
exaly +4 more sources
Association between copy number variation of complement component
Journal of Biomedical Science, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling +7 more
doaj +4 more sources
Divergence of C4A and C4B in first-episode psychosis: Insights from CSF and plasma immune profiling [PDF]
Translational PsychiatryThe complement genes C4A and C4B share high sequence similarity yet differ in biological function and disease relevance. C4A, in contrast to C4B, is implicated in synaptic pruning and increased risk for schizophrenia, however beyond this their distinct ...
Shokouh Arjmand +9 more
doaj +2 more sources
Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D [PDF]
Communications BiologyRecent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D).
Xiaowei Hu +10 more
doaj +2 more sources
Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases [PDF]
Frontiers in Immunology, 2016 The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner +7 more
doaj +4 more sources
Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for the Slp Gene of Complement Component C4 [PDF]
Brain SciencesBackground: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior.
Yasuhiko Yamamoto +13 more
doaj +2 more sources
Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures [PDF]
BMC MedicineBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among midlife women. Circulating extracellular vesicles (EVs) carry bioactive cargo that may mediate or reflect disease processes, but their role in hepatic steatosis ...
Patrick Pirrotte +11 more
doaj +2 more sources
Frontiers in GeneticsIntroduction: Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. One-third of the genetic contribution to this disease remains unexplained.Methods: We analyzed targeted sequencing data from two independent ...
Claudio Punzo +2 more
exaly +3 more sources
Complement system in dermatological diseases – fire under the skin [PDF]
Frontiers in Medicine, 2015 The complement system plays a key role in several dermatological diseases. Overactivation, deficiency or abnormality of the control proteins are often related to a skin disease.
Jaana Helena Panelius +4 more
doaj +2 more sources