Results 1 to 10 of about 26,400 (209)

Divergence of C4A and C4B in first-episode psychosis: Insights from CSF and plasma immune profiling [PDF]

Translational Psychiatry
The complement genes C4A and C4B share high sequence similarity yet differ in biological function and disease relevance. C4A, in contrast to C4B, is implicated in synaptic pruning and increased risk for schizophrenia, however beyond this their distinct ...
Shokouh Arjmand, Mridul Chaudhary, Samudyata, Fredrik Piehl, Aurimantas Pelanis, Göran Engberg, Simon Cervenka, Mikael Landén, Sophie Erhardt, Carl M. Sellgren   +9 more
doaj   +2 more sources

Complement C4A Regulates Autoreactive B Cells in Murine Lupus [PDF]

Cell Reports, 2020
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll   +6 more
doaj   +3 more sources

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction. [PDF]

PLoS ONE, 2012
Low protein levels and copy number variation (CNV) of the fourth component of human complement (C4A and C4B) have been associated with various diseases. High-throughput methods for analysing C4 CNV are available, but they commonly do not detect the most ...
Riitta Paakkanen, Hanna Vauhkonen, Katja T Eronen, Asko Järvinen, Mikko Seppänen, Marja-Liisa Lokki   +5 more
doaj   +5 more sources

Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for the Slp Gene of Complement Component C4 [PDF]

Brain Sciences
Background: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior.
Yasuhiko Yamamoto, Anpei Zhang, Anna A. Shabalova, Ai Harashima, Kyota Fujita, Teruko Yuhi, Yu Oshima, Pinyue Fu, Sei-ichi Munesue, Kana Minami, Kazuhiro Higashida, Hirokazu Kumazaki, Chiharu Tsuji, Haruhiro Higashida   +13 more
doaj   +2 more sources

Stabilization of C4a-Hydroperoxyflavin in a Two-component Flavin-dependent Monooxygenase Is Achieved through Interactions at Flavin N5 and C4a Atoms [PDF]

Journal of Biological Chemistry, 2011
إن إنزيم p - Hydroxyphenylacetate (HPA) 3 - hydroxylase هو إنزيم أحادي الأكسجين يعتمد على الفلافين ثنائي المكونات. استنادًا إلى البنية البلورية لمكون إنزيم الأكسجين (C(2))، فإن His -396 هو 4.5 Å من الموضع flavin C4a، في حين أن Ser -171 هو 2.9 Å من الموضع flavin N5. لقد حققنا في أدوار هاتين البقايا في استقرار وسيط C4a - hydroperoxy - FMN.
Jisnuson Svasti, Pirom Chenprakhon, Jeerus Sucharitakul   +2 more
exaly   +4 more sources

N5 Is the New C4a: Biochemical Functionalization of Reduced Flavins at the N5 Position

Frontiers in Molecular Biosciences, 2020
For three decades the C4a-position of reduced flavins was the known site for covalency within flavoenzymes. The reactivity of this position of the reduced isoalloxazine ring with the dioxygen ground-state triplet established the C4a as a site capable of ...
Graham R Moran
exaly   +3 more sources

Shear Wave Elastography to Quantitatively Assess the Early Changes of Skin Elasticity in Patients with Chronic Venous Disease of the Lower Extremity [PDF]

International Journal of General Medicine
Dan Lv,1,* Xi Yang,1,* Xin Mao,1,* Mei Zhang,1,* Xuemeihui Ma,1 Yuanyuan Liu,1 Guangsen Li,1 Bingbing Yang2 1Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116027 ...
Lv D, Yang X, Mao X, Zhang M, Ma X, Liu Y, Li G, Yang B   +7 more
doaj   +2 more sources

Deletion of C4A genes in patients with systemic lupus erythematosus [PDF]

Arthritis and Rheumatism, 1987
AbstractTo define the relationship between inheritance of major histocompatibility complex (MHC) alleles and susceptibility to the development of systemic lupus erythematosus (SLE), we examined the MHC class I, II, and III phenotypes of white SLE patients and characterized the structures of their class III MHC genes, using Southern blotting. Nine of 88
John P Atkinson
exaly   +3 more sources

Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures [PDF]

BMC Medicine
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among midlife women. Circulating extracellular vesicles (EVs) carry bioactive cargo that may mediate or reflect disease processes, but their role in hepatic steatosis ...
Patrick Pirrotte, Brooke Lovell, Siobán D. Harlow, Carrie A. Karvonen-Gutierrez, Michelle M. Hood, Ignazio S. Piras, Xiumei Wu, Melissa N. Martinez, Ritin Sharma, Krystine Garcia-Mansfield, Maya Willey, Johanna K. DiStefano   +11 more
doaj   +2 more sources

Correction: Copy Number Analysis of Complement C4A, C4B and C4A Silencing Mutation by Real-Time Quantitative Polymerase Chain Reaction

PLoS ONE, 2012
There was an error in the Competing Interests statement. The correct Competing interests are: MLL is working as a consultant at a company owned by the University of Helsinki providing complement C4 analysis for diagnostic samples. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors
Paakkanen, Riitta, Vauhkonen, Hanna, Eronen, Katja T., Järvinen, Asko, Seppänen, Mikko, Lokki, Marja-Liisa   +5 more
doaj   +4 more sources