Results 1 to 10 of about 7,925 (224)
Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy? [PDF]
BiologyEmerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins +5 more
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C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]
International Journal of Retina and VitreousBackground Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias +4 more
doaj +2 more sources
PLoS Neglected Tropical Diseases, 2021 The complement system is activated in tuberculous pleural effusion (TPE), with increased levels of the anaphylatoxins stimulating pleural mesothelial cells (PMCs) to secrete chemokines, which recruit nonclassical monocytes to the pleural cavity.
Shuanglinzi Deng +8 more
doaj +1 more source
Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis
Cells, 2022 The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth +14 more
doaj +1 more source
Biomedicines, 2023 The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today.
Marta Budkowska +11 more
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Biomedicines, 2021 Activation of the complement system is important for efficient clearance of a wide variety of pathogens via opsonophagocytosis, or by direct lysis via complement-dependent cytotoxicity (CDC).
Carolin Schmidt +8 more
doaj +1 more source
Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]
PLoS ONE, 2011 The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel +6 more
doaj +1 more source
Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease
Frontiers in Cellular and Infection Microbiology, 2022 Chagas disease, caused by the intracellular pathogen Trypanosoma cruzi, is the parasitic disease with the greatest impact in Latin America and the most common cause of infectious myocarditis in the world.
María Belén Caputo +6 more
doaj +1 more source
Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]
, 2012 Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara +6 more
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Anaphylatoxins spark the flame in early autoimmunity
Frontiers in Immunology, 2022 The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher +3 more
doaj +1 more source