Results 1 to 10 of about 4,803 (176)

Anaphylatoxins spark the flame in early autoimmunity

Frontiers in Immunology, 2022
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Joerg Koehl, Kohl Jörg, Karsten Christian M   +2 more
exaly   +3 more sources

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

Frontiers in Immunology, 2021
COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve the complement pathway activation for cytokine storm development. Nevertheless, the
Maaweya E Awadalla, Mushira Abdulaziz Enani, Wael Alturaiki   +2 more
exaly   +3 more sources

Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy? [PDF]

Biology
Emerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins, Valeria Molina, Stanley Wiernicki, Kenneth Okwuegbe, Xiaodong Feng, Hongbin Wang   +5 more
doaj   +2 more sources

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

Frontiers in Immunology, 2017
PurposeThe retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells;
Peter Zipfel, Olaf Strauss, Balasubramaniam Annamalai   +2 more
exaly   +3 more sources

C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]

International Journal of Retina and Vitreous
Background Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias, Iara Messias-Reason, Germano Ramos Boff, Kenzo Hokazono, Renato Nisihara   +4 more
doaj   +2 more sources

Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion.

PLoS Neglected Tropical Diseases, 2021
The complement system is activated in tuberculous pleural effusion (TPE), with increased levels of the anaphylatoxins stimulating pleural mesothelial cells (PMCs) to secrete chemokines, which recruit nonclassical monocytes to the pleural cavity.
Shuanglinzi Deng, Xinyue Hu, Lisha Luo, Wei Tang, Yuanyuan Jiang, Feifei Yin, Chengping Hu, Juntao Feng, Xiaozhao Li   +8 more
doaj   +1 more source

Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis

Cells, 2022
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer   +14 more
doaj   +1 more source

Biomarkers of the Complement System Activation (C3a, C5a, sC5b-9) in Serum of Patients before and after Liver Transplantation

Biomedicines, 2023
The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today.
Marta Budkowska, Ewa Ostrycharz, Natalia Maria Serwin, Łukasz Nazarewski, Elżbieta Cecerska-Heryć, Marta Poręcka, Paweł Rykowski, Radosław Pietrzak, Krzysztof Zieniewicz, Aldona Siennicka, Beata Hukowska-Szematowicz, Barbara Dołęgowska   +11 more
doaj   +1 more source

The Dual Role of a Polyvalent IgM/IgA-Enriched Immunoglobulin Preparation in Activating and Inhibiting the Complement System

Biomedicines, 2021
Activation of the complement system is important for efficient clearance of a wide variety of pathogens via opsonophagocytosis, or by direct lysis via complement-dependent cytotoxicity (CDC).
Carolin Schmidt, Sabrina Weißmüller, Fabian Bohländer, Matthias Germer, Martin König, Alexander Staus, Andrea Wartenberg-Demand, Corina C. Heinz, Jörg Schüttrumpf   +8 more
doaj   +1 more source

Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]

PLoS ONE, 2011
The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel, Sylvie Cointe, Pascal Maurice, Saïd Matar, Marta Ghitescu, Pierre Théroux, Arnaud Bonnefoy   +6 more
doaj   +1 more source