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Complement C5a Implication in Axonal Growth After Injury [PDF]

Cells
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to ...
Aurélie Cotten, Charlotte Jeanneau, Patrick Decherchi, Imad About   +3 more
doaj   +5 more sources

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody [PDF]

Journal of Innate Immunity, 2023
Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka, Ida Mariegaard, Mikkel-Ole Skjødt, Rafael Bayarri-Olmos, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg   +6 more
doaj   +2 more sources

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure [PDF]

Biological Psychiatry Global Open Science
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee   +7 more
doaj   +2 more sources

Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis

Cells, 2022
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer   +14 more
doaj   +1 more source

C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d

Frontiers in Immunology, 2022
Numerous publications have underlined the link between complement C5a and the clinical course of COVID-19. We previously reported that levels of C5a remain high in the group of severely ill patients up to 90 days after hospital discharge.
Daria Kowalska, Alicja Kuźniewska, Yaiza Senent, Yaiza Senent, Yaiza Senent, Beatriz Tavira, Beatriz Tavira, Beatriz Tavira, Susana Inogés, Susana Inogés, Susana Inogés, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ruben Pio, Ruben Pio, Ruben Pio, Ruben Pio, Marcin Okrój, José Ramón Yuste, José Ramón Yuste, José Ramón Yuste   +21 more
doaj   +1 more source

A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce

Scientific Reports, 2022
A complement effect on homeostasis during infection is determined by both cytotoxic (activate complement component 5 (C5a) terminal cytotoxic complex (TCC)), and cytoprotective elements (complement factor H (FH), as well as apolipoprotein E (ApoE)). Here,
Krzysztof Laudanski, Tony Okeke, Kumal Siddiq, Jihane Hajj, Mariana Restrepo, Damodar Gullipalli, Wen-chao Song   +6 more
doaj   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Important roles of C5a and C5aR in tumor development and cancer treatment [PDF]

E3S Web of Conferences, 2019
The complement system is part of the body's innate defense immune system, which can identify and eliminate invasive pathogenic microorganisms to maintain normal life activities.
Yuxuan Wang
doaj   +1 more source

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy [PDF]

Cancer Cell, 2018
Tiziana Cotechini, Justin J Leitenberger, Molly Kulesz-Martin   +2 more
exaly   +2 more sources

Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease. [PDF]

PLoS ONE, 2015
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, and inflammation. Here we explored complement inflammatory effectors in CF lung fluid.
Laura A Sass, Pamela S Hair, Amy M Perkins, Tushar A Shah, Neel K Krishna, Kenji M Cunnion   +5 more
doaj   +1 more source