Results 1 to 10 of about 36,145 (228)

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P, Barlow, Paul N, Cook, H. T, Cooke, Katie, Denton, Harriet, Kavanagh, David, Liszewski, M. K, Marchbank, Kevin J, Pappworth, Isabel Y, Pickering, Matthew C, Smith-Jackson, Kate, Yang, Yi   +11 more
core   +3 more sources

Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy?

Biology
Emerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins, Valeria Molina, Stanley Wiernicki, Kenneth Okwuegbe, Xiaodong Feng, Hongbin Wang   +5 more
doaj   +1 more source

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

Pharmacological Stimulation of Phagocytosis Enhances Amyloid Plaque Clearance; Evidence from a Transgenic Mouse Model of ATTR Neuropathy

Frontiers in Molecular Neuroscience, 2017
Hereditary ATTR V30M amyloidosis is a lethal autosomal dominant sensorimotor and autonomic neuropathy caused by deposition of aberrant transthyretin (TTR).
Eleni Fella, Eleni Fella, Kleitos Sokratous, Kleitos Sokratous, Revekka Papacharalambous, Kyriacos Kyriacou, Kyriacos Kyriacou, Joy Phillips, Sam Sanderson, Elena Panayiotou, Theodoros Kyriakides, Theodoros Kyriakides   +11 more
doaj   +1 more source

Cerebrospinal Fluid Profiles in Parkinson’s Disease: No Accumulation of Glucosylceramide, but Significant Downregulation of Active Complement C5 Fragment

Journal of Parkinson’s Disease, 2021
Background: As mutations in glucocerebrosidase 1 ( GBA1 ) are a major risk factor for Parkinson’s disease (PD), decreased GBA1 activity might play an important role in the pathogenesis of the disease.
Yoshiki Niimi, Yasuaki Mizutani, Hisako Akiyama, Hirohisa Watanabe, Ryoichi Shiroki, Yoshio Hirabayashi, Kiyotaka Hoshinaga, Tatsuro Mutoh   +7 more
doaj   +1 more source

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Journal of Translational Medicine, 2019
Background Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ensure adequate treatment.
Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth, Werner Dammermann   +4 more
doaj   +1 more source

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration

Journal of Translational Medicine, 2011
Background Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pathogenesis.
Klein Michael L, Chan Chi-Chao, Agron Elvira, Chakrabarty Sagarika, Li Zhiyu, Sen H Nida, Tuo Jingsheng, Meyerle Catherine, Wei Lai, Liu Baoying, Chew Emily, Ferris Frederick, Nussenblatt Robert B   +12 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]

, 1993
Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kroworsch, Peter, Schweiberer, Leonhard, Shimamoto, Kazuaki, Siebeck, Matthias, Spannagl, Michael, Weipert, Joachim   +8 more
core   +1 more source