Results 1 to 10 of about 698 (115)

Function, structure and therapeutic potential of complement C5a receptors [PDF]

British Journal of Pharmacology, 2007
Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury.
Peter Monk
exaly   +6 more sources

Complement C5a Implication in Axonal Growth After Injury

Cells
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to ...
Aurélie Cotten, Charlotte Jeanneau, Patrick Decherchi, Imad About   +3 more
doaj   +3 more sources

Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis

Cells, 2022
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer   +14 more
doaj   +1 more source

C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d

Frontiers in Immunology, 2022
Numerous publications have underlined the link between complement C5a and the clinical course of COVID-19. We previously reported that levels of C5a remain high in the group of severely ill patients up to 90 days after hospital discharge.
Daria Kowalska, Alicja Kuźniewska, Yaiza Senent, Yaiza Senent, Yaiza Senent, Beatriz Tavira, Beatriz Tavira, Beatriz Tavira, Susana Inogés, Susana Inogés, Susana Inogés, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ascensión López-Díaz de Cerio, Ruben Pio, Ruben Pio, Ruben Pio, Ruben Pio, Marcin Okrój, José Ramón Yuste, José Ramón Yuste, José Ramón Yuste   +21 more
doaj   +1 more source

A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce

Scientific Reports, 2022
A complement effect on homeostasis during infection is determined by both cytotoxic (activate complement component 5 (C5a) terminal cytotoxic complex (TCC)), and cytoprotective elements (complement factor H (FH), as well as apolipoprotein E (ApoE)). Here,
Krzysztof Laudanski, Tony Okeke, Kumal Siddiq, Jihane Hajj, Mariana Restrepo, Damodar Gullipalli, Wen-chao Song   +6 more
doaj   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Important roles of C5a and C5aR in tumor development and cancer treatment [PDF]

E3S Web of Conferences, 2019
The complement system is part of the body's innate defense immune system, which can identify and eliminate invasive pathogenic microorganisms to maintain normal life activities.
Yuxuan Wang
doaj   +1 more source

Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease. [PDF]

PLoS ONE, 2015
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, and inflammation. Here we explored complement inflammatory effectors in CF lung fluid.
Laura A Sass, Pamela S Hair, Amy M Perkins, Tushar A Shah, Neel K Krishna, Kenji M Cunnion   +5 more
doaj   +1 more source

Complement C5a Generation by Staphylococcal Biofilms [PDF]

Shock, 2013
Biofilms production is a central feature of nosocomial infection of catheters and other medical devices used in resuscitation and critical care. However, the very effective biofilm forming pathogen Staphylococcus epidermidis often produces a modest host inflammatory response and few of the signs and symptoms associated with more virulent pathogens.
Ashley E, Satorius, Jacob, Szafranski, Derek, Pyne, Mahesh, Ganesan, Michael J, Solomon, Duane W, Newton, David M, Bortz, John G, Younger   +7 more
openaire   +2 more sources

Association of C5a/C5aR pathway to activate ERK1/2 and p38 MAPK in acute kidney injury – a mouse model

Romanian Journal of Laboratory Medicine, 2022
Acute inflammation is accompanied by complement system activation and inflammatory cell accumulation. Acute kidney injury (AKI) is one of the common clinical symptoms, it is not clear whether complement system-mediated signaling pathway is involved. This
Zhang Zeying
doaj   +1 more source