Results 11 to 20 of about 20,066 (195)

The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics [PDF]

Trends in Immunology, 2020
The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy ...
Woodruff, Trent M., Shukla, Arun K.
europepmc   +7 more sources

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody [PDF]

Journal of Innate Immunity, 2023
Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka, Ida Mariegaard, Mikkel-Ole Skjødt, Rafael Bayarri-Olmos, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg   +6 more
doaj   +2 more sources

Role of complement C5a and histones in septic cardiomyopathy [PDF]

Molecular Immunology, 2018
Polymicrobial sepsis (after cecal ligation and puncture, CLP) causes robust complement activation with release of C5a. Many adverse events develop thereafter and will be discussed in this review article. Activation of complement system results in generation of C5a which interacts with its receptors (C5aR1, C5aR2).
Fatemeh Fattahi, Lynn M. Frydrych, Guowu Bian, Miriam Kalbitz, Todd J. Herron, Elizabeth A. Malan, Matthew J. Delano, Peter A. Ward   +7 more
openaire   +4 more sources

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure [PDF]

Biological Psychiatry Global Open Science
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee   +7 more
doaj   +2 more sources

Complement C5a‐Induced Changes in Neutrophil Morphology During Inflammation [PDF]

Scandinavian Journal of Immunology, 2017
AbstractThe complement and neutrophil defence systems, as major components of innate immunity, are activated during inflammation and infection. For neutrophil migration to the inflamed region, we hypothesized that the complement activation product C5a induces significant changes in cellular morphology before chemotaxis. Exposure of human neutrophils to
S. Denk, R. P. Taylor, R. Wiegner, E. M. Cook, M. A. Lindorfer, K. Pfeiffer, S. Paschke, T. Eiseler, M. Weiss, E. Barth, J. D. Lambris, M. Kalbitz, T. Martin, H. Barth, D. A. C. Messerer, F. Gebhard, M. S. Huber‐Lang   +16 more
openaire   +3 more sources

Association of C5a/C5aR pathway to activate ERK1/2 and p38 MAPK in acute kidney injury – a mouse model

Romanian Journal of Laboratory Medicine, 2022
Acute inflammation is accompanied by complement system activation and inflammatory cell accumulation. Acute kidney injury (AKI) is one of the common clinical symptoms, it is not clear whether complement system-mediated signaling pathway is involved. This
Zhang Zeying
doaj   +1 more source

Nociceptive sensitization by complement C5a and C3a in mouse [PDF]

Pain, 2010
Activation of the complement system by injury increases inflammation by producing complement fragments C5a and C3a which are able to recruit and activate immune cells. Complement activation may contribute to pain after inflammation and injury. In this study, we examined whether C5a and C3a elicit nociception when injected into mouse hind paws in vivo ...
Jun Ho, Jang, David J, Clark, Xiangqi, Li, Matthew S, Yorek, Yuriy M, Usachev, Timothy J, Brennan   +5 more
openaire   +2 more sources

The complement system and its role in the treatment of ANCA-associated vasculitis

Journal of Education, Health and Sport, 2022
Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis.   Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the
Natalia Rybak, Iga Dudek, Jakub Czarnota, Michał Dobrzyński, Tomasz Skubel, Małgorzata Drozd   +5 more
doaj   +1 more source

Complement Factor C5a Inhibits Apoptosis of Neutrophils—A Mechanism in Polytrauma? [PDF]

Journal of Clinical Medicine, 2021
Life-threatening polytrauma results in early activation of the complement and apoptotic system, as well as leukocytes, ultimately leading to the clearance of damaged cells. However, little is known about interactions between the complement and apoptotic systems in PMN (polymorphonuclear neutrophils) after multiple injuries. PMN from polytrauma patients
Christian Ehrnthaller, Sonja Braumüller, Stephanie Kellermann, Florian Gebhard, Mario Perl, Markus Huber-Lang   +5 more
openaire   +2 more sources

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source