Results 11 to 20 of about 405,861 (246)
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics. [PDF]
Trends Immunol, 2020 The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy ...
Woodruff TM, Shukla AK.
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New insights for C5a and C5a receptors in sepsis [PDF]
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
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Complement C5a receptors in the pituitary gland: expression and function [PDF]
Journal of Endocrinology, 2008 Communication between the immune and endocrine system is important for the control of inflammation that is primarily mediated through the hypothalamic–pituitary–adrenal axis. The innate immune system rapidly responds to pathogens by releasing complement proteins that include the anaphylatoxins C3a and C5a.
Karen, Francis +3 more
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Complement Anaphylatoxin C5a, Endothelial Dysfunction and Low-Grade Inflammation in Atherosclerotic Vascular Diseases [PDF]
Central Asian Journal of Medical Sciences, 2018 Objectives: The objective of the paper is to summarize the evidence in atherosclerosis research regarding the relationship of complement C5a with low-grade inflammation, endothelial dysfunction, and atherosclerosis.
Gansuvd Shagdarsuren +4 more
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Complement Factor C5a Inhibits Apoptosis of Neutrophils—A Mechanism in Polytrauma? [PDF]
Journal of Clinical Medicine, 2021 Life-threatening polytrauma results in early activation of the complement and apoptotic system, as well as leukocytes, ultimately leading to the clearance of damaged cells. However, little is known about interactions between the complement and apoptotic systems in PMN (polymorphonuclear neutrophils) after multiple injuries. PMN from polytrauma patients
Christian Ehrnthaller +5 more
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Complement C5a inhibition reduces atherosclerosis in ApoE –/– mice
The FASEB Journal, 2011 ABSTRACT The complement C5a receptor, CD88, is present on many of the cells found within human atherosclerotic plaques, but little is known about the role of C5a in atherogenesis. Using real‐time PCR, we determined that ApoE –/–
Manthey, Helga D. +6 more
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The effect of complement C5a on mitochondrial functions of PC12 cells
NeuroReport, 2011 C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during apoptosis, we investigated mitochondria as a potential target for C5a.
Ryan D, Martinus, Christian J, Cook
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Increased local concentration of complement C5a contributes to incisional pain in mice [PDF]
Journal of Neuroinflammation, 2011 Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J +5 more
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Complement C5A regulates prolabor mediators in human placenta.
Biology of reproduction, 2012 Human preterm and term parturition is associated with inflammatory cascades in the uteroplacental unit. Activation of the complement cascade releases potent proinflammatory mediators, including the anaphylatoxin C5a, which exerts its biological effects through its receptors, C5AR (also known as CD88) and C5L2, official symbol GPR77.
Lappas, Martha +3 more
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Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease. [PDF]
Int J Mol Sci, 2023 Diabetic kidney disease (DKD) affects 30–40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserved element of the innate immune system, has been ...
Trambas IA, Coughlan MT, Tan SM.
europepmc +2 more sources