Complement C5a Implication in Axonal Growth After Injury [PDF]
CellsComplement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to ...
Aurélie Cotten +3 more
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New insights for C5a and C5a receptors in sepsis [PDF]
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
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Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody [PDF]
Journal of Innate Immunity, 2023 Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka +6 more
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Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. [PDF]
PLoS ONE, 2014 There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Hua Hua Tong +8 more
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Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure [PDF]
Biological Psychiatry Global Open ScienceBackground: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen +7 more
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Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge [PDF]
Frontiers in Immunology, 2021 Daniel Ajona +2 more
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C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]
International Journal of Retina and VitreousBackground Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias +4 more
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The Complement System in ANCA‐Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs [PDF]
Immunity, Inflammation and DiseaseBackground ANCA‐associated vasculitides (AAV) are autoimmune small‐vessel vasculitides characterized by necrotizing inflammation with few immune deposits (“pauci‐immune” lesions).
Kehinde Sunmboye, Pauline Millan
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Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis
Cells, 2022 The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth +14 more
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Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy [PDF]
Cancer Cell, 2018 Dhaarini Murugan +2 more
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