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Enhancement of Macrophage Phagocytosis by Complement Component C5a
Enhancement of Macrophage Phagocytosis by Complement Component C5aTo investigate the modulatory function of complement component C5a in macrophages, the effects of C5a on macrophage phagocytosis were examined by means of fluorescent polystyrene particles and flow cytometry. We found that C5a enhanced the phagocytosis of latex beads in mouse peritoneal macrophages.
Ichinose, Mitsuyuki, Hirota, Akihiko
openaire +2 more sources
Role of complement C5a and histones in septic cardiomyopathy. [PDF]
Mol Immunol, 2018 Polymicrobial sepsis (after cecal ligation and puncture, CLP) causes robust complement activation with release of C5a. Many adverse events develop thereafter and will be discussed in this review article. Activation of complement system results in generation of C5a which interacts with its receptors (C5aR1, C5aR2).
Fattahi F +7 more
europepmc +4 more sources
Complement C5a Generation by Staphylococcal Biofilms [PDF]
Shock, 2013 Biofilms production is a central feature of nosocomial infection of catheters and other medical devices used in resuscitation and critical care. However, the very effective biofilm forming pathogen Staphylococcus epidermidis often produces a modest host inflammatory response and few of the signs and symptoms associated with more virulent pathogens.
Ashley E, Satorius +7 more
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Romanian Journal of Laboratory Medicine, 2022 Acute inflammation is accompanied by complement system activation and inflammatory cell accumulation. Acute kidney injury (AKI) is one of the common clinical symptoms, it is not clear whether complement system-mediated signaling pathway is involved. This
Zhang Zeying
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundHeart surgery results in complement activation with the potential for collateral end-organ damage, especially if the protective elements (complement factor H, Apolipoprotein J) are inadequate. Here, we have investigated if peri-operative stress
Krzysztof Laudanski +7 more
doaj +1 more source
The complement system and its role in the treatment of ANCA-associated vasculitis
Journal of Education, Health and Sport, 2022 Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis. Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the
Natalia Rybak +5 more
doaj +1 more source
Nociceptive sensitization by complement C5a and C3a in mouse [PDF]
Pain, 2010 Activation of the complement system by injury increases inflammation by producing complement fragments C5a and C3a which are able to recruit and activate immune cells. Complement activation may contribute to pain after inflammation and injury. In this study, we examined whether C5a and C3a elicit nociception when injected into mouse hind paws in vivo ...
Jun Ho, Jang +5 more
openaire +2 more sources
The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
core +1 more source
Role of Complement and Histones in Sepsis
Frontiers in Medicine, 2020 The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
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Cell Reports, 2021 Summary: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8+ T cell responses by C5a have not been extensively explored.
Sae-Hae Kim +3 more
doaj +1 more source