Results 21 to 30 of about 405,066 (236)

Increased local concentration of complement C5a contributes to incisional pain in mice [PDF]

Journal of Neuroinflammation, 2011
Background In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contribution of ...
Clark David J, Sun Yuan, Kido Kanta, Liang Deyong, Jang Jun H, Brennan Timothy J   +5 more
doaj   +2 more sources

A decline of protective apolipoprotein J and complement factor H concomitant with increase in C5a 3 months after cardiac surgery—Evidence of long-term complement perturbations

Frontiers in Cardiovascular Medicine, 2022
BackgroundHeart surgery results in complement activation with the potential for collateral end-organ damage, especially if the protective elements (complement factor H, Apolipoprotein J) are inadequate. Here, we have investigated if peri-operative stress
Krzysztof Laudanski, Krzysztof Laudanski, Krzysztof Laudanski, Da Liu, Damodar Gullipalli, Wen-Chao Song, Tony Okeke, Wilson Y. Szeto   +7 more
doaj   +1 more source

The complement system and its role in the treatment of ANCA-associated vasculitis

Journal of Education, Health and Sport, 2022
Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis.   Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the
Natalia Rybak, Iga Dudek, Jakub Czarnota, Michał Dobrzyński, Tomasz Skubel, Małgorzata Drozd   +5 more
doaj   +1 more source

Nociceptive sensitization by complement C5a and C3a in mouse [PDF]

Pain, 2010
Activation of the complement system by injury increases inflammation by producing complement fragments C5a and C3a which are able to recruit and activate immune cells. Complement activation may contribute to pain after inflammation and injury. In this study, we examined whether C5a and C3a elicit nociception when injected into mouse hind paws in vivo ...
Jun Ho, Jang, David J, Clark, Xiangqi, Li, Matthew S, Yorek, Yuriy M, Usachev, Timothy J, Brennan   +5 more
openaire   +2 more sources

Enhancement of Macrophage Phagocytosis by Complement Component C5a

Enhancement of Macrophage Phagocytosis by Complement Component C5a
To investigate the modulatory function of complement component C5a in macrophages, the effects of C5a on macrophage phagocytosis were examined by means of fluorescent polystyrene particles and flow cytometry. We found that C5a enhanced the phagocytosis of latex beads in mouse peritoneal macrophages.
Ichinose, Mitsuyuki, Hirota, Akihiko
openaire   +2 more sources

The Role of Complement in Cancer Immunotherapy [PDF]

, 2022
The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...

core   +1 more source

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source

Complement C5a promotes antigen cross-presentation by Peyer’s patch monocyte-derived dendritic cells and drives a protective CD8+ T cell response

Cell Reports, 2021
Summary: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8+ T cell responses by C5a have not been extensively explored.
Sae-Hae Kim, Byeol-Hee Cho, Kwang Soon Kim, Yong-Suk Jang   +3 more
doaj   +1 more source

Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells

Journal of Neuroinflammation, 2022
Background We previously reported higher plasma levels of complement fragments C3a and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular fibrosis.
María Llorián-Salvador, Eimear M. Byrne, Manon Szczepan, Karis Little, Mei Chen, Heping Xu   +5 more
doaj   +1 more source

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase [PDF]

, 1986
The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-
M G Tonnesen, Guthrie, L A, P M Henson, G S Worthen, C Haslett, Tonnesen, M G, Smedly, LA, Worthen, G S, Sandhaus, R A, R B Johnston, Henson, P M, L A Guthrie, L A Smedly, Johnstone Jr., R.B, Haslett, Christopher, R A Sandhaus   +15 more
core   +1 more source