Results 21 to 30 of about 20,066 (195)
Cell Reports, 2021 Summary: The complement fragment C5a is closely associated with adaptive immune induction in the mucosa. However, the mechanisms that control CD8+ T cell responses by C5a have not been extensively explored.
Sae-Hae Kim +3 more
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New insights for C5a and C5a receptors in sepsis
Frontiers in Immunology, 2012 The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions.
Hongwei eGao, Chunguang eYan
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Journal of Neuroinflammation, 2022 Background We previously reported higher plasma levels of complement fragments C3a and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular fibrosis.
María Llorián-Salvador +5 more
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Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression
Journal of Neuroinflammation, 2022 Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho +10 more
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Central Asian Journal of Medical Sciences, 2018 Objectives: The objective of the paper is to summarize the evidence in atherosclerosis research regarding the relationship of complement C5a with low-grade inflammation, endothelial dysfunction, and atherosclerosis.
Gansuvd Shagdarsuren +4 more
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Complement C5a receptors C5L2 and C5aR in renal fibrosis [PDF]
American Journal of Physiology-Renal Physiology, 2018 Complement factor C5a has two known receptors, C5aR, which mediates proinflammatory effects, and C5L2, a potential C5a decoy receptor. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney. Here we tested for the first time the role of C5L2 in renal fibrosis.
Ina V. Martin +8 more
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Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. [PDF]
PLoS ONE, 2014 There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Hua Hua Tong +8 more
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Biomedicines, 2022 The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino +11 more
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Reduced order modeling and analysis of the human complement system. [PDF]
PLoS ONE, 2017 Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation.
Adithya Sagar +4 more
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Complement C5a receptors in the pituitary gland: expression and function [PDF]
Journal of Endocrinology, 2008 Communication between the immune and endocrine system is important for the control of inflammation that is primarily mediated through the hypothalamic–pituitary–adrenal axis. The innate immune system rapidly responds to pathogens by releasing complement proteins that include the anaphylatoxins C3a and C5a.
Karen, Francis +3 more
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