Results 41 to 50 of about 36,145 (228)
Central Asian Journal of Medical Sciences, 2018 Objectives: The objective of the paper is to summarize the evidence in atherosclerosis research regarding the relationship of complement C5a with low-grade inflammation, endothelial dysfunction, and atherosclerosis.
Gansuvd Shagdarsuren +4 more
doaj +1 more source
Biomedicines, 2022 The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs ...
Nicola Iacomino +11 more
doaj +1 more source
Complement and cytokine response in acute Thrombotic Thrombocytopenic Purpura [PDF]
, 2013 Complement dysregulation is key in the pathogenesis of atypical Haemolytic Uraemic Syndrome (aHUS), but no clear role for complement has been identified in Thrombotic Thrombocytopenic Purpura (TTP).
Heelas, E +4 more
core +1 more source
Reduced order modeling and analysis of the human complement system. [PDF]
PLoS ONE, 2017 Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation.
Adithya Sagar +4 more
doaj +1 more source
Complement C5a receptors C5L2 and C5aR in renal fibrosis [PDF]
American Journal of Physiology-Renal Physiology, 2018 Complement factor C5a has two known receptors, C5aR, which mediates proinflammatory effects, and C5L2, a potential C5a decoy receptor. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney. Here we tested for the first time the role of C5L2 in renal fibrosis.
Ina V. Martin +8 more
openaire +2 more sources
A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds [PDF]
, 2010 Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses.
AJ Wright +26 more
core +1 more source
Complement C5a receptors in the pituitary gland: expression and function [PDF]
Journal of Endocrinology, 2008 Communication between the immune and endocrine system is important for the control of inflammation that is primarily mediated through the hypothalamic–pituitary–adrenal axis. The innate immune system rapidly responds to pathogens by releasing complement proteins that include the anaphylatoxins C3a and C5a.
Karen, Francis +3 more
openaire +2 more sources
Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation. [PDF]
Scand J Immunol, 2017 AbstractThe complement and neutrophil defence systems, as major components of innate immunity, are activated during inflammation and infection. For neutrophil migration to the inflamed region, we hypothesized that the complement activation product C5a induces significant changes in cellular morphology before chemotaxis. Exposure of human neutrophils to
Denk S +16 more
europepmc +4 more sources
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]
, 2015 Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C +9 more
core +3 more sources
Serum complement factor C5a in IgG4-related disease [PDF]
Annals of the Rheumatic Diseases, 2019 We read with great interest the correspondence by Umehara et al 1 which discussed the difficulties in the diagnosis of IgG4-related disease (IgG4-RD). They mention that increased IgG4 concentration is not a specific marker for IgG4-RD. Therefore, the markers for the diagnosis and the disease activity of IgG4-RD are demanded. Approximately a quarter of
Shoichi, Fukui +4 more
openaire +2 more sources