The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Journal of Neuroinflammation, 2008 Background The complement system is thought to be involved in the pathogenesis of numerous neurological diseases. We previously reported that pre-treatment of murine cortico-hippocampal neuronal cultures with the complement derived anaphylatoxin C5a ...
Thomas Sunil +2 more
doaj +1 more source
Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway [PDF]
, 2007 Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence
Collins, Julie +11 more
core +2 more sources
Journal of the Formosan Medical Association, 2019 Background: The binding of anti-phospholipase A2 receptor (anti-PLA2R) antibody to podocyte and complement activation is the mechanisms of idiopathic membranous nephropathy (IMN).
Jyun Ni Chi +9 more
doaj +1 more source
Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiation
BMC Oral Health, 2021 Background During the process of deep decay, when decay approaches the pulp, an immune response is triggered inside the pulp, which activates the complement cascade.
Jie Liu +10 more
doaj +1 more source
Complement factor C5a induces atherosclerotic plaque disruptions [PDF]
Journal of Cellular and Molecular Medicine, 2014 AbstractComplement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE−/− mice.
Wezel, A. +6 more
openaire +4 more sources
Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients [PDF]
, 2014 Background: During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (reflected by circulating C5a) and
Beelen, R.H.J. (Robert) +7 more
core +3 more sources
The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. [PDF]
PLoS ONE, 2008 Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis.
Michael A Flierl +7 more
doaj +1 more source
SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate
Clinical & Translational Immunology, 2022 Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect.
Martin W Lo +10 more
doaj +1 more source
C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera
Frontiers in Immunology, 2021 Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França +6 more
doaj +1 more source