Results 1 to 10 of about 80 (79)

Cloning of the Human C5a Anaphylatoxin Receptor, and More

Frontiers in Immunology, 2015
Norma P Gérard
exaly   +3 more sources

The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis. [PDF]

PLoS ONE, 2018
The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis.
Jonathan Dick, Poh-Yi Gan, A Richard Kitching, Stephen R Holdsworth   +3 more
doaj   +1 more source

The complement system and its role in the treatment of ANCA-associated vasculitis

Journal of Education, Health and Sport, 2022
Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis.   Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the
Natalia Rybak, Iga Dudek, Jakub Czarnota, Michał Dobrzyński, Tomasz Skubel, Małgorzata Drozd   +5 more
doaj   +1 more source

Important roles of C5a and C5aR in tumor development and cancer treatment [PDF]

E3S Web of Conferences, 2019
The complement system is part of the body's innate defense immune system, which can identify and eliminate invasive pathogenic microorganisms to maintain normal life activities.
Yuxuan Wang
doaj   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]

PLoS ONE, 2013
Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A Wetsel, Silke Glage, Andreas Klos   +6 more
doaj   +1 more source

Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli

Frontiers in Immunology, 2022
Urticaria is characterized by the occurrence of wheals and flares in response to vasoactive mediators, such as histamine. Various studies have suggested the involvement of basophils in the pathogenesis of chronic spontaneous urticaria (CSU).
Daiki Matsubara, Yuhki Yanase, Kaori Ishii, Shunsuke Takahagi, Akio Tanaka, Koichiro Ozawa, Michihiro Hide, Michihiro Hide   +7 more
doaj   +1 more source

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

Journal of Innate Immunity, 2023
Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka, Ida Mariegaard, Mikkel-Ole Skjødt, Rafael Bayarri-Olmos, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg   +6 more
doaj   +1 more source

Complement Proteins C5/C5a, Cathepsin D and Prolactin in Chondrocytes: A Possible Crosstalk in the Pathogenesis of Osteoarthritis

Cells, 2022
Introduction: Both increased activity of the complement system (CS) and the role of the pituitary hormone prolactin (PRL) are implicated in osteoarthritis (OA) pathogenesis.
Sandeep Silawal, Miriam Wagner, Dominik Roth, Thomas Bertsch, Silke Schwarz, Maximilian Willauschus, Markus Gesslein, Jakob Triebel, Gundula Schulze-Tanzil   +8 more
doaj   +1 more source

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis

Frontiers in Cellular Neuroscience, 2023
BackgroundThe extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying leptomeninges, a more inflammatory CSF milieu and with ...
Rhian Evans, Lewis M. Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I. Rees, Denise Fitzgerald, B. Paul Morgan, James W. Neal, Owain W. Howell   +11 more
doaj   +1 more source