Cloning of the Human C5a Anaphylatoxin Receptor, and More [PDF]
Frontiers in Immunology, 2015 The initial observation in 1973 that the complement C5 activation product, C5a, has the ability to stimulate human neutrophils led to the concept of a specific C5a receptor (1). In the mid-1986, a groundbreaking paper published in Nature announced the cloning of the beta-adrenergic receptor, and for the first time established seven transmembrane (7TM ...
Norma P Gérard +2 more
exaly +7 more sources
Effect of C5a Receptor Antagonist on the Osteogenic Differentiation of Dental Pulp Stem Cells. [PDF]
Clin Exp Dent ResABSTRACT Objective Complement component 5a (C5a) binding to its receptor (C5aR) can mediate pro‐inflammatory immune responses, which impairs osteogenic differentiation of dental pulp stem cells (DPSCs). The present study aimed to evaluate the regulatory effect of C5aR antagonist (W54011) on the osteogenic differentiation of DPSCs in an in vitro ...
Tan X +7 more
europepmc +2 more sources
Activation of B1 B cells by F. tularensis atypical LPS depends on classical complement and C3a. [PDF]
PLoS PathogensFrancisella tularensis (Ft), a Gram-negative bacterium that causes tularemia, possesses a non-inflammatory atypical LPS (LPSFt) that is highly immunogenic through unknown mechanism.
Guilherme Melo +4 more
doaj +2 more sources
The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis. [PDF]
PLoS ONE, 2018 The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis.
Jonathan Dick +3 more
doaj +1 more source
The complement system and its role in the treatment of ANCA-associated vasculitis
Journal of Education, Health and Sport, 2022 Objective: This study aimed to evaluate the role of the complement system in a therapy of the ANCA- associated vasculitis. Methods and materials: A literature search was conducted in the PubMed MEADLINE database of medical publications using the
Natalia Rybak +5 more
doaj +1 more source
Important roles of C5a and C5aR in tumor development and cancer treatment [PDF]
E3S Web of Conferences, 2019 The complement system is part of the body's innate defense immune system, which can identify and eliminate invasive pathogenic microorganisms to maintain normal life activities.
Yuxuan Wang
doaj +1 more source
Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins
Frontiers in Immunology, 2021 Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West +8 more
doaj +1 more source
The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. [PDF]
PLoS ONE, 2013 Inflammatory bowel diseases are a critical public health issue, and as treatment options remain limited, there is a need to unravel the underlying pathomechanisms in order to identify new therapeutic targets.
Elisabeth Wende +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Urticaria is characterized by the occurrence of wheals and flares in response to vasoactive mediators, such as histamine. Various studies have suggested the involvement of basophils in the pathogenesis of chronic spontaneous urticaria (CSU).
Daiki Matsubara +7 more
doaj +1 more source
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
Journal of Innate Immunity, 2023 Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka +6 more
doaj +1 more source