Results 31 to 40 of about 6,320 (210)

Characterization of a Receptor for C5a Anaphylatoxin on Human Eosinophils

Journal of Biological Chemistry, 1989
The complement anaphylatoxin peptide C5a is well known to activate human polymorphonuclear leukocytes through receptor-mediated processes. C5a has also been reported to activate eosinophils for both chemotaxis and hexose uptake. We characterized the receptor molecule for human C5a on human eosinophils and compared it with the receptor on human ...
N P, Gerard, M K, Hodges, J M, Drazen, P F, Weller, C, Gerard   +4 more
openaire   +2 more sources

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"? [PDF]

, 2011
Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system in contributing to the pathogenesis of ...
Miriam D Neher, Sebastian Weckbach, Michael A Flierl, Markus S Huber-Lang, Philip F Stahel   +4 more
core   +2 more sources

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Acta Neuropathologica Communications, 2018
The complement system is a key driver of neuroinflammation. Activation of complement by all pathways, results in the formation of the anaphylatoxin C5a and the membrane attack complex (MAC).
Iliana Michailidou, Aldo Jongejan, Jeroen P. Vreijling, Theodosia Georgakopoulou, Marit B. de Wissel, Ruud A. Wolterman, Patrick Ruizendaal, Ngaisah Klar-Mohamad, Anita E. Grootemaat, Daisy I. Picavet, Vinod Kumar, Cees van Kooten, Trent M. Woodruff, B. Paul Morgan, Nicole N. van der Wel, Valeria Ramaglia, Kees Fluiter, Frank Baas   +17 more
doaj   +1 more source

Complement in the homeostatic and ischemic brain [PDF]

, 2015
The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue
Aivazian, Akita, Alexander, Amara, Arumugam, Atkinson, Austen, Barber, Barber, Bednar, Beek, Bellander, Benard, Benard, Benoit, Boos, Busche, Carmichael, Carmichael, Carmichael, Cavusoglu, Cervera, Chu, Cojocaru, Costa, Cowell, Crane, Cudrici, Davoust, De La Rosa, De Simoni, De Simoni, Di Napoli, Ducruet, Ducruet, Ducruet, Ducruet, Elvington, Elvington, Engstrom, Figueroa, Fisher, Frauenknecht, Garrett, Gasque, Gasque, Gesuete, Gill, Harboe, Harhausen, Heese, Heimann, Hoke, Holers, Huang, Huber-Lang, Hurtado, Iadecola, Imm, Jauneau, Katzan, Kim, Kramer, Kulik, Levi-Strauss, Lew, Li, Li, Lindsberg, Luo, Mack, McMullen, Mead, Mehta, Mocco, Mocco, Mocco, Moriyama, Morrison, Mukherjee, Mukherjee, Murphy, Olsson, Orsini, Osaka, Osthoff, Patel, Pavlovski, Pedersen, Pedersen, Pedersen, Persson, Pisalyaput, Rahpeymai, Ramaglia, Ricklin, Rogers, Rupprecht, Rynkowski, Schafer, Schafer, Schultz, Shinjyo, Soane, Somani, Speidl, Stahel, Stephan, Stevens, Stokowska, Stokowska, Storini, Széplaki, Ten, Ten, Thundyil, Thurman, Tohgi, Van Beek, Vasthare, Wieloch, Williams, Yang, Zee, Zhang, Zhang, Zhang, Zhang, Zhang, Zipfel   +129 more
core   +3 more sources

Treatment of Rare Inflammatory Kidney Diseases: Drugs Targeting the Terminal Complement Pathway

Frontiers in Immunology, 2020
The complement system comprises the frontline of the innate immune system. Triggered by pathogenic surface patterns in different pathways, the cascade concludes with the formation of a membrane attack complex (MAC; complement components C5b to C9) and ...
Marion Anliker-Ort, Marion Anliker-Ort, Jasper Dingemanse, John van den Anker, John van den Anker, Priska Kaufmann   +5 more
doaj   +1 more source

Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury

Frontiers in Immunology, 2022
Polyphosphates are linear polymers of inorganic phosphates that exist in all living cells and serve pleiotropic functions. Bacteria produce long-chain polyphosphates, which can interfere with host defense to infection.
Julian Roewe, Sarah Walachowski, Arjun Sharma, Arjun Sharma, Kayleigh A. Berthiaume, Christoph Reinhardt, Markus Bosmann, Markus Bosmann   +7 more
doaj   +1 more source

Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]

, 2018
Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean, Halliday, Christopher, Jahagirdar, Ravi, Johansson, Jan O, Kalantar-Zadeh, Kamyar, Kulikowski, Ewelina, Robson, Richard, Stotz, Stephanie C, Sweeney, Michael, Tsujikawa, Laura M, Wasiak, Sylwia, Wong, Norman C   +11 more
core   +2 more sources

Cloning and preliminary pharmacological characterization of the anaphylatoxin C5a receptor in the rabbit [PDF]

British Journal of Pharmacology, 1999
The rabbit receptor for C5a was cloned from a genomic library and found to be 79.5% identical to the human homologue, the highest degree of similarity found so far in nonprimate laboratory animals. The rabbit C5a receptor stably expressed in RBL cells binds human 125I‐C5a (2 nM). Unlabelled C5a and the C‐terminal analogue N‐acetyl‐Tyr‐Ser‐Phe‐Lys‐Pro‐
D R, Bachvarov, S, Houle, M, Bachvarova, J, Bouthillier, S A, St-Pierre, Y, Fukuoka, J A, Ember, F, Marceau   +7 more
openaire   +2 more sources

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer. [PDF]

Clin Transl Med
Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Bennion A, Lysaght J, Lynam-Lennon N.
europepmc   +2 more sources

TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection

Frontiers in Immunology, 2023
BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He, Xianggui Yang, Kai Yang, Honglin Xu, Cheng Chen, Junxiong Wang, Jun Zeng   +6 more
doaj   +1 more source