Cloning and preliminary pharmacological characterization of the anaphylatoxin C5a receptor in the rabbit [PDF]
British Journal of Pharmacology, 1999 The rabbit receptor for C5a was cloned from a genomic library and found to be 79.5% identical to the human homologue, the highest degree of similarity found so far in nonprimate laboratory animals. The rabbit C5a receptor stably expressed in RBL cells binds human 125I‐C5a (2 nM). Unlabelled C5a and the C‐terminal analogue N‐acetyl‐Tyr‐Ser‐Phe‐Lys‐Pro‐
D R, Bachvarov +7 more
openaire +2 more sources
TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection
Frontiers in Immunology, 2023 BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He +6 more
doaj +1 more source
The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview
Biochimie, 2007 Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of a gradient of locally produced chemotactic factors. This review is focused on current knowledge about the activation and regulation of chemoattractant receptors.
Rabiet, Marie-Josèphe +2 more
openaire +4 more sources
Sulfated Tyrosines Contribute to the Formation of the C5a Docking Site of the Human C5a Anaphylatoxin Receptor [PDF]
The Journal of Experimental Medicine, 2001 The complement anaphylatoxin C5a and its seven-transmembrane segment (7TMS) receptor play an important role in host defense and in a number of inflammation-associated pathologies. The NH2-terminal domain of the C5a receptor (C5aR/CD88) contributes substantially to its ability to bind C5a.
M, Farzan +7 more
openaire +2 more sources
Human Plasmacytoid Dendritic Cells Express Receptors for Anaphylatoxins C3a and C5a and Are Chemoattracted to C3a and C5a [PDF]
Journal of Investigative Dermatology, 2006 The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases. Since anaphylatoxins or their precursors were also found in such lesions, we investigated a possible interaction between pDC and anaphylatoxins C3a and C5a.
Gutzmer, Ralf +6 more
openaire +3 more sources
Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. [PDF]
PLoS ONE, 2017 The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts.
Stephanie Bergdolt +7 more
doaj +1 more source
An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization [PDF]
Journal of Clinical Investigation, 2006 The anaphylatoxins complement component 3a and 5a (C3a and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause bronchoconstriction. A few years ago, controversy arose when it was shown that C5-deficient mice were more susceptible to experimental asthma compared
openaire +2 more sources
Frontiers in Immunology, 2023 IntroductionDNA methylation was one of the most important modification in epigenetics and played an important role in immune response. Since the introduction of Scophthalmus maximus, the scale of breeding has continued to expand, during which diseases ...
Yingrui Li +5 more
doaj +1 more source
Expression and induction of anaphylatoxin C5a receptors in the rat liver.
Histology and histopathology, 2003 The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G. +5 more
openaire +3 more sources
Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. [PDF]
PLoS ONE, 2011 Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusion ...
Guido Moll +12 more
doaj +1 more source