Results 31 to 40 of about 1,239,345 (193)

Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury

Frontiers in Immunology, 2022
Polyphosphates are linear polymers of inorganic phosphates that exist in all living cells and serve pleiotropic functions. Bacteria produce long-chain polyphosphates, which can interfere with host defense to infection.
Julian Roewe, Sarah Walachowski, Arjun Sharma, Arjun Sharma, Kayleigh A. Berthiaume, Christoph Reinhardt, Markus Bosmann, Markus Bosmann   +7 more
doaj   +1 more source

Cloning and preliminary pharmacological characterization of the anaphylatoxin C5a receptor in the rabbit [PDF]

British Journal of Pharmacology, 1999
The rabbit receptor for C5a was cloned from a genomic library and found to be 79.5% identical to the human homologue, the highest degree of similarity found so far in nonprimate laboratory animals. The rabbit C5a receptor stably expressed in RBL cells binds human 125I‐C5a (2 nM). Unlabelled C5a and the C‐terminal analogue N‐acetyl‐Tyr‐Ser‐Phe‐Lys‐Pro‐
D R, Bachvarov, S, Houle, M, Bachvarova, J, Bouthillier, S A, St-Pierre, Y, Fukuoka, J A, Ember, F, Marceau   +7 more
openaire   +2 more sources

TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection

Frontiers in Immunology, 2023
BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He, Xianggui Yang, Kai Yang, Honglin Xu, Cheng Chen, Junxiong Wang, Jun Zeng   +6 more
doaj   +1 more source

The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview

Biochimie, 2007
Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of a gradient of locally produced chemotactic factors. This review is focused on current knowledge about the activation and regulation of chemoattractant receptors.
Rabiet, Marie-Josèphe, Huet, Emilie, Boulay, François   +2 more
openaire   +4 more sources

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. [PDF]

PLoS ONE, 2017
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts.
Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius   +7 more
doaj   +1 more source

An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization [PDF]

Journal of Clinical Investigation, 2006
The anaphylatoxins complement component 3a and 5a (C3a and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause bronchoconstriction. A few years ago, controversy arose when it was shown that C5-deficient mice were more susceptible to experimental asthma compared
openaire   +2 more sources

Human Plasmacytoid Dendritic Cells Express Receptors for Anaphylatoxins C3a and C5a and Are Chemoattracted to C3a and C5a [PDF]

Journal of Investigative Dermatology, 2006
The presence of plasmacytoid dendritic cells (pDC) was recently demonstrated in lesions of inflammatory skin diseases. Since anaphylatoxins or their precursors were also found in such lesions, we investigated a possible interaction between pDC and anaphylatoxins C3a and C5a.
Gutzmer, Ralf, Koether, Brigitta, Zwirner, Joerg, Dijkstra, Dorothea, Purwar, Rahul, Wittmann, Miriam, Werfel, Thomas   +6 more
openaire   +3 more sources

Immunity of turbot Induced by inactivated vaccine of Aeromonas salmonicida from the perspective of DNA methylation

Frontiers in Immunology, 2023
IntroductionDNA methylation was one of the most important modification in epigenetics and played an important role in immune response. Since the introduction of Scophthalmus maximus, the scale of breeding has continued to expand, during which diseases ...
Yingrui Li, Lin Su, Xiaofei Liu, Huimin Guo, Shun Zhou, Yunji Xiu   +5 more
doaj   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver.

Histology and histopathology, 2003
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H.L., Götze, O.   +5 more
openaire   +3 more sources

Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

, 2016
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure ...
Garland R. Marshall (727036), Thomas J. Baranski (104900), Gregory V. Nikiforovich (2450236)   +2 more
core   +1 more source