Results 51 to 60 of about 6,320 (210)

Mesenchymal stromal cells engage complement and complement receptor bearing innate effector cells to modulate immune responses. [PDF]

PLoS ONE, 2011
Infusion of human third-party mesenchymal stromal cells (MSCs) appears to be a promising therapy for acute graft-versus-host disease (aGvHD). To date, little is known about how MSCs interact with the body's innate immune system after clinical infusion ...
Guido Moll, Regina Jitschin, Lena von Bahr, Ida Rasmusson-Duprez, Berit Sundberg, Lena Lönnies, Graciela Elgue, Kristina Nilsson-Ekdahl, Dimitrios Mougiakakos, John D Lambris, Olle Ringdén, Katarina Le Blanc, Bo Nilsson   +12 more
doaj   +1 more source

Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance. [PDF]

, 2020
Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia.
Agarwal, Priyanka, Angara, Bryan, Bhowmick, Neil A, Billet, Sandrine, Duong, Frank, Haldar, Subhash, Madhav, Anisha, Mishra, Rajeev, Placencio-Hickok, Veronica R, Posadas, Edwin M, Thiruvalluvan, Manish, Tighiouart, Mourad   +11 more
core  

The interaction between C 5a and both C 5a R and C 5 L 2 receptors is required for production of G ‐ CSF during acute inflammation [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99020/1/eji2635 ...
Bamberg, Bosmann, Bosmann, Bosmann, Bosmann, Bosmann, Bosmann, Cain, Chen, Gerard, Gerard, Gerard, Hawlisch, Hopken, Huber-Lang, Jalili, Kourtzelis, Lajoie, Lalli, Laudes, Lee, Okinaga, Ricklin, Riedemann, Riedemann, Rittirsch, Strainic, Wetsel, Wittmann, Zhang, Zhang, Zheng   +31 more
core   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. [PDF]

PLoS ONE, 2017
Diabetic non-healing wounds are a major clinical problem. The mechanisms leading to poor wound healing in diabetes are multifactorial but unresolved inflammation may be a major contributing factor.
Kenji M Cunnion, Neel K Krishna, Haree K Pallera, Angela Pineros-Fernandez, Magdielis Gregory Rivera, Pamela S Hair, Brittany P Lassiter, Ryan Huyck, Mary A Clements, Antoinette F Hood, George T Rodeheaver, Patrick S Cottler, Jerry L Nadler, Anca D Dobrian   +13 more
doaj   +1 more source

Toxoplasma Infection Induces Sustained Up-Regulation of Complement Factor B and C5a Receptor in the Mouse Brain via Microglial Activation: Implication for the Alternative Complement Pathway Activation and Anaphylatoxin Signaling in Cerebral Toxoplasmosis

Frontiers in Immunology, 2021
Toxoplasma gondii is a neurotropic protozoan parasite, which is linked to neurological manifestations in immunocompromised individuals as well as severe neurodevelopmental sequelae in congenital toxoplasmosis.
Noriko Shinjyo, Noriko Shinjyo, Noriko Shinjyo, Kenji Hikosaka, Yasutoshi Kido, Hiroki Yoshida, Kazumi Norose   +6 more
doaj   +1 more source

Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu [PDF]

, 2009
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Alan A. Okada, Ekowati E. Handharyani, Hidechika H. Okada, Kazuhide K. Adachi, Masaki M. Imai, Noriko N. Okada, Retno Damajanti R. D. Soejoedono, Yasuhiro Tsukamoto   +7 more
core   +1 more source

Complement Split Product C5a Mediates the Lipopolysaccharide‐Induced Mobilization of Cfu‐S and Haemopoietic Progenitor Cells, But Not the Mobilization Induced By Proteolytic Enzymes [PDF]

, 1986
. Intravenous (i.v.) injection of mice with lipopolysaccharide (LPS), and the proteolytic enzymes trypsin and proteinase, mobilizes pluripotent haemopoietic stem cells (CFU‐s) as well as granulocyte‐macrophage progenitor cells (GM‐CFU) and the early ...
Benner R., Bertoncello I., Cline M.J., Daha M.R., Daha M.R., Daha M.R., Daha M.R., Fernandez H.N., Goodman J.W., Ham A.C., Hara M., Hugli T.E., Kessel K.P.M., Loor F., Molenaar J.L., Molendijk W.J., Perez H.D., Ploemacher R.E., Rickard K.A., Rosen F.S., Ross W.M., Snyderman R., Snyderman R., Vos O., Vos O., Wilschut I.J.C.   +25 more
core   +1 more source

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]

, 2018
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura, Giusti, Pietro, Skaper, Stephen D., Zusso, Morena   +3 more
core   +2 more sources

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source