Results 71 to 80 of about 6,320 (210)
mBio, 2018 Sepsis caused by Neisseria meningitidis (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e., when the systemic inflammatory response is ...
Johannes B. Herrmann +7 more
doaj +1 more source
Complement is activated in progressive multiple sclerosis cortical grey matter lesions [PDF]
, 2016 The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing ...
A Bose +51 more
core +2 more sources
Cardiopulmonary and hemodynamic changes in complement activation-related pseudoallergy [PDF]
, 2013 Complement activation-related pseudoallergy (CARPA) is a frequent side effect of intravenous therapies with nanoparticle-containing drugs and biologicals that are recognized by the immune system as foreign.
Dézsi, László +4 more
core +1 more source
Xenotransplantation, Volume 33, Issue 2, March/April 2026.ABSTRACT Background In pig‐to‐nonhuman primate islet transplantation, reliable, sensitive biomarkers are needed to detect graft damage at an early stage before irreversible islet loss occurs. In our study, we investigated donor‐derived cell‐free DNA (dd‐cfDNA) as an early, noninvasive biomarker of graft injury by analyzing its correlation with porcine ...
Ji‐Jing Yan +10 more
wiley +1 more source
Renal C3 complement component: feed forward to diabetic kidney disease [PDF]
, 2015 BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. METHODS: Comprehensive genomic profiling (RNAseq) was employed in the ZS (F1 hybrids of Zucker and spontaneously hypertensive heart ...
Dominguez, Jesus H. +3 more
core +2 more sources
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye +10 more
wiley +1 more source
Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis [PDF]
, 2017 While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-β signaling, the specific hierarchical interactions between TGF-β and complement in lung fibrosis are unclear.
Cipolla, Ellyse +5 more
core +2 more sources
Evaluation of L-selectin expression and assessment of protein tyrosine phosphorylation in bovine polymorphonuclear neutrophil leukocytes around parturition. [PDF]
, 2002 Impaired polymorphonuclear neutrophil leukocyte (PMN) function around parturition has been associated with increased clinical mastitis in dairy cows. Rolling and attachment of PMN to the endothelium is the first step in the recruitment process and is ...
Burvenich, Christian +6 more
core +1 more source
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu +11 more
wiley +1 more source
Frontiers in Immunology, 2017 Activation of antigen-presenting dendritic cells (DCs) and the complement system are essential early events in the immune defense against invading pathogens.
Anouk Zaal +15 more
doaj +1 more source