Results 71 to 80 of about 3,783 (170)

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, Volume 81, Issue 8, Page 2726-2743, August 2026.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Pathophysiological mechanisms of disease severity in COVID-19: An update

Journal of Advanced Biotechnology and Experimental Therapeutics
The pandemic of COVID-19 has created a confounding global health crisis with more than 25 million cases and 870,000 deaths worldwide. The novel coronavirus, SARS-CoV-2, exploits the human ACE2 receptor and potential CD147 to invade a plethora of organ ...
Md. Hasanul Banna Siam, Shah MD Minhajul Abedin, Ahsan Ahmed, Nahida Hannan Nishat, Mohammad Sorowar Hossain   +4 more
doaj   +1 more source

CEG-0598, a novel dual inhibitor of EGFR and C5aR demonstrates in vitro anticancer and antimetastatic activity in prostate cancer cells

Discover Oncology
Background The EGFR is abundantly expressed in prostate cancer (PC). The anaphylatoxin C5a induces leukocyte migration via the C5a receptor (C5aR) by releasing matrix metalloproteinases (MMP) to favor metastasis in the tumor microenvironment.
Ayed A. Dera, Majed Al Fayi
doaj   +1 more source

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Aquaculture Nutrition
Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear.
Yixin Gu, Yu Zhan, Yafeng Guo, Wenyuan Hua, Xin Qi, Zhizhi Gu, Shengnan Cao, Yan Chen, Zhuang Xue, Wei Wang   +9 more
doaj   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Respiratory Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced ...
Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana   +12 more
doaj   +1 more source

Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis

ESC Heart Failure
Aims Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF).
Tess E. Peterson, Joao A.C. Lima, Sanjiv J. Shah, David A. Bluemke, Alain G. Bertoni, Yongmei Liu, Debby Ngo, Vinithra Varadarajan, Josyf C. Mychaleckyj, Craig W. Johnson, Bruce M. Psaty, Clary B. Clish, Kent D. Taylor, Peter Durda, Russell P. Tracy, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Wendy S. Post, James S. Pankow   +19 more
doaj   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver

, 2018
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H. L., Gotze, O.   +5 more
openaire   +1 more source

Complement tumor-crosstalk: the role of C5a receptors in urothelial carcinomas. [PDF]

Front Immunol
Lütje LS, Gruner C, Karsten CM, Merseburger AS, Roesch MC.   +4 more
europepmc   +1 more source

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review. [PDF]

Orthop Rev (Pavia)
Counts PR, Baer TM, Viswanath O, Ganti L.   +3 more
europepmc   +1 more source

Carboxypeptidase M deficiency aggravates complement-induced lung injury. [PDF]

iScience
Qadri F, Zhang C, Schütz A, Popova E, Czaplinska BA, Zemechmann K, Greckl R, Alenina N, Pesquero JB, Rodrigues AF, Bader M.   +10 more
europepmc   +1 more source