Results 71 to 80 of about 3,648 (168)

CEG-0598, a novel dual inhibitor of EGFR and C5aR demonstrates in vitro anticancer and antimetastatic activity in prostate cancer cells

Discover Oncology
Background The EGFR is abundantly expressed in prostate cancer (PC). The anaphylatoxin C5a induces leukocyte migration via the C5a receptor (C5aR) by releasing matrix metalloproteinases (MMP) to favor metastasis in the tumor microenvironment.
Ayed A. Dera, Majed Al Fayi
doaj   +1 more source

Targeting complement anaphylatoxin C5a receptor in hyperoxic lung injury in mice

Molecular Medicine Reports, 2014
Receptor binding of complement anaphylatoxin C5a results in proinflammatory activation of numerous diseases, but the role of receptor-mediated action during hyperoxic lung injury has, to the best of our knowledge, not yet been investigated. The contribution of the C5a receptor (C5aR) to hyperoxic lung injury in mice was investigated in this study.
XU, YING, TIAN, ZHE, XIE, PEIYU
openaire   +3 more sources

Complement and transplant‐associated thrombotic microangiopathy: Current and future approaches

HemaSphere, Volume 10, Issue 4, April 2026.
Massimo Cugno, Francesco Onida, Bernhard Lämmle   +2 more
wiley   +1 more source

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Aquaculture Nutrition
Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear.
Yixin Gu, Yu Zhan, Yafeng Guo, Wenyuan Hua, Xin Qi, Zhizhi Gu, Shengnan Cao, Yan Chen, Zhuang Xue, Wei Wang   +9 more
doaj   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Respiratory Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced ...
Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana   +12 more
doaj   +1 more source

Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis

ESC Heart Failure
Aims Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF).
Tess E. Peterson, Joao A.C. Lima, Sanjiv J. Shah, David A. Bluemke, Alain G. Bertoni, Yongmei Liu, Debby Ngo, Vinithra Varadarajan, Josyf C. Mychaleckyj, Craig W. Johnson, Bruce M. Psaty, Clary B. Clish, Kent D. Taylor, Peter Durda, Russell P. Tracy, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Wendy S. Post, James S. Pankow   +19 more
doaj   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver

, 2018
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H. L., Gotze, O.   +5 more
openaire   +1 more source

The Role of Complement Component C5a in the Pathogenesis of Diabetic Kidney Disease: A New Kid on the Block? [PDF]

Cureus
Geladari V, Paschou E, Betsikos A, Pallas D, Sabanis N.   +4 more
europepmc   +1 more source

The Complement System in the Setting of Critical Illness-A Narrative Review. [PDF]

Biomolecules
Ampelakiotou K, Nikitopoulou I, Kokkoris S, Kotanidou A, Dimopoulou I, Detsika MG.   +5 more
europepmc   +1 more source

Activation of the C3a-C3aReceptor-axis is associated with endothelial dysfunction and glycocalyx damage in ST-elevation myocardial infarction. [PDF]

Basic Res Cardiol
Vahldieck C, Löning S, Hamacher C, Fels B, Svensson T, Rudzewski B, Weil J, Kusche K.   +7 more
europepmc   +1 more source