Results 71 to 80 of about 1,239,345 (193)

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, Volume 81, Issue 8, Page 2726-2743, August 2026.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1292-1301, July 2026.
This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo, Ziheng Yan, Jingyu Ye, Ruifu Yang, Yajun Song, Hui Yue, Yong Zhao   +6 more
wiley   +1 more source

Targeting complement anaphylatoxin C5a receptor in hyperoxic lung injury in mice

Molecular Medicine Reports, 2014
Receptor binding of complement anaphylatoxin C5a results in proinflammatory activation of numerous diseases, but the role of receptor-mediated action during hyperoxic lung injury has, to the best of our knowledge, not yet been investigated. The contribution of the C5a receptor (C5aR) to hyperoxic lung injury in mice was investigated in this study.
XU, YING, TIAN, ZHE, XIE, PEIYU
openaire   +3 more sources

Effects of the anaphylatoxin, C5a, on renal and glomerular hemodynamics in the rat [PDF]

, 1986
Effects of the anaphylatoxin, C5a, on renal and glomerular hemodynamics in the rat. The effects of intrarenal infusion of the complement–derived anaphylatoxin, C5a, upon glomerular hemodynamics were examined in the Munich–Wistar rat, a strain with ...
Pelayo, Juan C., Chenoweth, Dennis E., Hugli, Tony E., Wilson, Curtis B., Blantz, Roland C.   +4 more
core   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity [PDF]

, 2014
Evasion of killing by the complement system, a crucial part of innate immunity, is a key evolutionary strategy of many human pathogens. A major etiological agent of chronic periodontitis, the Gram-negative bacterium Porphyromonas gingivalis produces a ...
Mizgalska, Danuta, Enghild, Jan J, Prossnitz, Eric, Potempa, Jan, Jusko, Monika, Kantyka, Tomasz, Scavenius, Carsten, Blom, Anna M., Bielecka, Ewa, Potempa, Barbara, Blom, Anna, Prossnitz, Eric R., Szmigielski, Borys, Enghild, Jan J.   +13 more
core   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Role of the complement anaphylatoxin C5a-receptor pathway in atopic dermatitis in mice

Molecular Medicine Reports, 2015
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic background. The C5a‑receptor (C5aR) pathway has been reported to be involved in AD; however, the precise pathogenesis remains to be elucidated. In the present study, the contribution of the C5aR pathway to AD in mice was investigated.
DANG, LIN, HE, LEI, WANG, YAN, XIONG, JIKUI, BAI, BINGXUE, LI, YUZHEN   +5 more
openaire   +3 more sources

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

Frontiers in Immunology, 2019
Background: Ischemia reperfusion injury (IRI) plays a major role in solid organ transplantation. The length of warm ischemia time is critical for the extent of tissue damage in renal IRI.
Li Wang, Vijith Vijayan, Mi-Sun Jang, Anja Thorenz, Robert Greite, Song Rong, Rongjun Chen, Nelli Shushakova, Igor Tudorache, Katja Derlin, Pooja Pradhan, Kukuh Madyaningrana, Nodir Madrahimov, Jan Hinrich Bräsen, Ralf Lichtinghagen, Cees van Kooten, Markus Huber-Lang, Hermann Haller, Stephan Immenschuh, Faikah Gueler   +19 more
doaj   +1 more source