Results 61 to 70 of about 3,648 (168)

C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease

Pharmacogenomics and Personalized Medicine, 2021
Jessica Kristin Henes,1,* Patrick Groga-Bada,1,* Elke Schaeffeler,2,3 Stefan Winter,2,3 Luis Hack,1 Monika Zdanyte,1 Karin Mueller,1 Michal Droppa,1 Fabian Stimpfle,1 Meinrad Gawaz,1 Harald Langer,4 Matthias Schwab,2,3,5,6 Tobias Geisler,1 ...
Henes JK, Groga-Bada P, Schaeffeler E, Winter S, Hack L, Zdanyte M, Mueller K, Droppa M, Stimpfle F, Gawaz M, Langer H, Schwab M, Geisler T, Rath D   +13 more
doaj  

Urine Proteomic Profiling at Admission Reveals Complement Biomarkers Linked to Alcohol‐Associated Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
Patients with alcohol‐associated hepatitis (AH) and alcohol‐cirrhosis (AC) show perturbations in complement. Complement activation pathways are perturbed in the urine of patients with AH and AC, and distinguish severe AH from AC. Complement perturbations can help physicians and researchers to understand the liver–kidney crosstalk in severe AH and AC ...
Luan Prado, Ryan Musich, Moyinoluwa Taiwo, Vai Pathak, Daniel M. Rotroff, Annette Bellar, Nicole Welch, Jaividhya Dasarathy, David Streem, for the AlcHepNet, Srinivasan Dasarathy, Laura E. Nagy   +11 more
wiley   +1 more source

Novel interactions between the C5‐C5aR1 Axis and IF1: Implications for kidney mitochondrial physiology and ischemia–reperfusion injury

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Ischemia‐reperfusion injury (IRI) is a prevalent condition that predominantly afflicts hospitalized patients, inducing acute kidney injury (AKI). In recent years, complement 5 (C5) and its anaphylatoxin receptor C5aR1 have been implicated in driving kidney IRI and loss of function.
Madison McGraw, Amod Sharma, Dinesh Bhattarai, Neriman Gokden, LeeAnn Macmillan‐Crow, Nirmala Parajuli   +5 more
wiley   +1 more source

Role of the complement anaphylatoxin C5a-receptor pathway in atopic dermatitis in mice

Molecular Medicine Reports, 2015
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic background. The C5a‑receptor (C5aR) pathway has been reported to be involved in AD; however, the precise pathogenesis remains to be elucidated. In the present study, the contribution of the C5aR pathway to AD in mice was investigated.
DANG, LIN, HE, LEI, WANG, YAN, XIONG, JIKUI, BAI, BINGXUE, LI, YUZHEN   +5 more
openaire   +3 more sources

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Noninvasive Monitoring of Complement Using the Bioluminescent Modified Ham Assay in the Second Porcine‐to‐Human Live Heart Transplant

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Complement activation is a major barrier to xenotransplantation. We report detailed complement monitoring in a 58‐year‐old man who received a 10 gene–edited porcine heart expressing human complement regulators CD46 and CD55. Despite these transgenes and prophylactic systemic complement inhibition with C1 esterase inhibitor (C1INH), early ...
Michael A. Cole, Andy Tully, Javier Galindo, Avneesh K. Singh, Meryl Waldman, Janhavi Athale, Idris Boudhabhay, Erwan Morgand, Fariza Mezine, Valentin Goutaudier, Aurélie Sannier, Brad Lewis, Jamey Kain, Mike Ero, Lubka Roumenina, Patrick Bruneval, Robert Christenson, Lo Tamburro, Alan Burke, Cinthia Drachenburg, Alexandre Loupy, David Ayares, Robert A. Brodsky, Bartley P. Griffith, Muhammad M. Mohiuddin, Alison Grazioli   +25 more
wiley   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

Frontiers in Immunology, 2019
Background: Ischemia reperfusion injury (IRI) plays a major role in solid organ transplantation. The length of warm ischemia time is critical for the extent of tissue damage in renal IRI.
Li Wang, Vijith Vijayan, Mi-Sun Jang, Anja Thorenz, Robert Greite, Song Rong, Rongjun Chen, Nelli Shushakova, Igor Tudorache, Katja Derlin, Pooja Pradhan, Kukuh Madyaningrana, Nodir Madrahimov, Jan Hinrich Bräsen, Ralf Lichtinghagen, Cees van Kooten, Markus Huber-Lang, Hermann Haller, Stephan Immenschuh, Faikah Gueler   +19 more
doaj   +1 more source

Donor‐Derived Cell‐Free DNA (dd‐cfDNA) as an Early Noninvasive Biomarker of Graft Injury in Pig‐to‐Monkey Islet Xenotransplantation

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT Background In pig‐to‐nonhuman primate islet transplantation, reliable, sensitive biomarkers are needed to detect graft damage at an early stage before irreversible islet loss occurs. In our study, we investigated donor‐derived cell‐free DNA (dd‐cfDNA) as an early, noninvasive biomarker of graft injury by analyzing its correlation with porcine ...
Ji‐Jing Yan, Jong‐Min Kim, Sang‐Ik Cho, Hyori Kim, Kyungmin Kwak, Hyunil Kim, Eun‐Jee Oh, Jaeseok Yang, Chung‐Gyu Park, Jong Cheol Jeong, Beom Seok Kim   +10 more
wiley   +1 more source

Pathophysiological mechanisms of disease severity in COVID-19: An update

Journal of Advanced Biotechnology and Experimental Therapeutics
The pandemic of COVID-19 has created a confounding global health crisis with more than 25 million cases and 870,000 deaths worldwide. The novel coronavirus, SARS-CoV-2, exploits the human ACE2 receptor and potential CD147 to invade a plethora of organ ...
Md. Hasanul Banna Siam, Shah MD Minhajul Abedin, Ahsan Ahmed, Nahida Hannan Nishat, Mohammad Sorowar Hossain   +4 more
doaj   +1 more source