Results 61 to 70 of about 6,320 (210)

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction

Frontiers in Immunology, 2018
Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory
Hilde L. Orrem, Hilde L. Orrem, Hilde L. Orrem, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke, Ola Kleveland, Ola Kleveland, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Karin Ekholt, Karin Ekholt, Jan K. Damås, Terje Espevik, Bjørn Bendz, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Ida Gregersen, Ida Gregersen, Rune Wiseth, Rune Wiseth, Geir Ø. Andersen, Geir Ø. Andersen, Geir Ø. Andersen, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Andreas Barratt-Due, Andreas Barratt-Due, Andreas Barratt-Due, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes   +54 more
doaj   +1 more source

Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis [PDF]

, 2009
INTRODUCTION: Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear.
Flierl, M A, Stahel, P F, Rittirsch, D, Huber-Lang, M, Niederbichler, A D, Hoesel, L M, Touban, B M, Morgan, S J, Smith, W R, Ward, P A, Ipaktchi, K   +10 more
core   +2 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Antagonism of the prostaglandin D₂ receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

Respiratory Research, 2007
Background Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a high affinity receptor for ...
Högberg Thomas, Ulven Trond, Korsgren Magnus, Alenmyr Lisa, Mathiesen Jesper, Uller Lena, Andersson Gunnar, Persson Carl GA, Kostenis Evi   +8 more
doaj   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo [PDF]

Journal of Biological Chemistry, 1995
Interaction of human C5a anaphylatoxin with cell surface receptors mediates cell activation and receptor desensitization. Treatment of differentiated HL60 cells or transiently transfected COS-7 cells with C5a or phorbol 12-myristate 12-acetate (PMA) results in rapid hyperphosphorylation of the C5aR.
E, Giannini, L, Brouchon, F, Boulay
openaire   +2 more sources

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +1 more source