Results 81 to 90 of about 1,239,345 (193)

Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats

Physiological Reports, Volume 14, Issue 14, July 2026.
Comparative proteomic analysis of kidneys from C3‐/‐ and C5‐/‐ rats following ischemia‐reperfusion injury (IRI) reveals diverse range of renal injury and repair mechanisms. C3 knockout enhanced mitochondrial, metabolic, and purine pathways while suppressing immune and extracellular matrix programs. In contrast, C5 absences affected extracellular matrix
Dinesh Bhattarai, Amod Sharma, Madison McGraw, Se‐Ran Jun, Neelam Joshi, Neriman Gokden, Samuel Mackintosh, Nirmala Parajuli   +7 more
wiley   +1 more source

Expression and Role of Anaphylatoxin Receptors on Human Colonic Epithelial Cells

, 2012
Human colonic epithelial cell lines (T84, Caco2 and HT-29) were used to address the question of whether intestinal epithelial cells can detect and respond to activated complement via the anaphylatoxin receptors, considering the gut is host to large ...
Cao, Qi
core  

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Evaluation of the C5a anaphylatoxin and its receptor (CD88) in allergic lung disease

, 2008
Allergic asthma is characterized by airflow obstruction, airway hyperresponsiveness (AHR) and chronic airway inflammation. We and others have reported that complement component C3 and the anaphylatoxin C3a receptor promote while C5 protects against the ...
Sinha, Meenal
core   +1 more source

Pathophysiological mechanisms of disease severity in COVID-19: An update

Journal of Advanced Biotechnology and Experimental Therapeutics
The pandemic of COVID-19 has created a confounding global health crisis with more than 25 million cases and 870,000 deaths worldwide. The novel coronavirus, SARS-CoV-2, exploits the human ACE2 receptor and potential CD147 to invade a plethora of organ ...
Md. Hasanul Banna Siam, Shah MD Minhajul Abedin, Ahsan Ahmed, Nahida Hannan Nishat, Mohammad Sorowar Hossain   +4 more
doaj   +1 more source

CEG-0598, a novel dual inhibitor of EGFR and C5aR demonstrates in vitro anticancer and antimetastatic activity in prostate cancer cells

Discover Oncology
Background The EGFR is abundantly expressed in prostate cancer (PC). The anaphylatoxin C5a induces leukocyte migration via the C5a receptor (C5aR) by releasing matrix metalloproteinases (MMP) to favor metastasis in the tumor microenvironment.
Ayed A. Dera, Majed Al Fayi
doaj   +1 more source

Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration

, 1999
In this study we explored the potential role of the complement derived anaphylatoxin C5a and the expression of its receptor in mouse brain. Using in situ hybridization, we found that C5a receptor messenger RNA is expressed in mouse brain.
Gerard, C., Hoepken, U.E., Lu, Wanhua, Pasinetti, G.M., H. Osaka, C. Gerard, A. McGinty, B. Lu, McGinty, Ann, Osaka, H., Höpken, U.E., Lu, B., G.M. Pasinetti, U.E. Höpken, McGinty, A.   +14 more
core   +3 more sources

Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin [PDF]

, 1988
When stimulated with immune complex or C5a anaphylatoxin, human neutrophils undergo an increase in the concentration of intracellular Ca2+ ([Ca2+]i) that precedes the onset of superoxide (O−2) production.
Shirato, Manabu, Koyama, Jiro, Manabu Shirato, Shigeharu Nagasawa, Takahashi, Kazuhiko, Jiro Koyama, Nagasawa, Shigeharu, Kazuhiko Takahashi   +7 more
core   +1 more source

A proton nuclear magnetic resonance study of the conformation of bovine anaphylatoxin C5a in solution [PDF]

, 1988
The solution conformation of bovine anaphylatoxin C5a has been investigated by nuclear magnetic resonance (NMR) spectroscopy. The 1H-NMR spectrum is assigned in a sequential manner using a variety of two-dimensional NMR techniques.
Jutta Zarbock, Gennaro, Renato, Renato Gennaro, Domenico Romeo, G.Marius Clore, Zarbock, Jutta, Romeo, Domenico, Clore, G.Marius, Angela M. Gronenborn, G. Marius Clore, Gronenborn, Angela M.   +10 more
core   +1 more source

Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin [PDF]

, 2015
Excessive activation of the complement system is detrimental in acute inflammatory disorders. In this study, we analyzed the role of complement‐derived anaphylatoxins in the pathogenesis of experimental acute lung injury/acute respiratory distress ...
Bethany B. Moore, Russkamp, Norman F., Norman F. Russkamp, Robert Ruemmler, Ruemmler, Robert, Moore, Bethany B., Julian Roewe, Peter A. Ward, Markus Bosmann, Bosmann, Markus, Ward, Peter A., Roewe, Julian   +11 more
core   +1 more source