Results 81 to 90 of about 6,320 (210)

Site‐specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor [PDF]

European Journal of Biochemistry, 1994
To check and clarify existing data on receptor‐interacting residues in the human C5a anaphylatoxin, we tested mutant C5a proteins obtained by site‐directed mutagenesis of a recombinant human C5a (rhC5a) cDNA clone for structural and functional integrity.
P, Bubeck, J, Grötzinger, M, Winkler, J, Köhl, A, Wollmer, A, Klos, W, Bautsch   +6 more
openaire   +2 more sources

C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease

Pharmacogenomics and Personalized Medicine, 2021
Jessica Kristin Henes,1,* Patrick Groga-Bada,1,* Elke Schaeffeler,2,3 Stefan Winter,2,3 Luis Hack,1 Monika Zdanyte,1 Karin Mueller,1 Michal Droppa,1 Fabian Stimpfle,1 Meinrad Gawaz,1 Harald Langer,4 Matthias Schwab,2,3,5,6 Tobias Geisler,1 ...
Henes JK, Groga-Bada P, Schaeffeler E, Winter S, Hack L, Zdanyte M, Mueller K, Droppa M, Stimpfle F, Gawaz M, Langer H, Schwab M, Geisler T, Rath D   +13 more
doaj  

Expression of C5a and its receptor in canine spontaneous tumours: a preliminary finding [PDF]

, 2016
A study of the development of spontaneous tumours in dogs gives many benefits in oncology research due to the similarity between dog and human cancer in terms of epidemiologic, biologic and clinical features.
Ahmad, Hafandi, Bachek, Noor Farhana, Ganti, Norhaifa, Kamarudin, Nurul Hazwani, Kosni, Nurneqman Nashreq, Md. Ajat, Mohd Mokrish, Mohd Noor, Mohd Hezmee, Selvarajah, Gayathri Thevi   +7 more
core  

Reprogramming Immunogenicity of Iron Oxide Nanoparticles through Sulfated Glycan Presentation

Small, Volume 22, Issue 11, 20 February 2026.
This study presents a comparative analysis of heparin (HP)‐ and dextran sulfate (DS)‐coated superparamagnetic iron oxide nanoparticles (SPIONs) as a tunable immunomodulatory platform where surface chemistry dictates therapeutic function. DS‐SPIONs are preferentially internalized by myeloid cells, reprogramming them into a pro‐healing M2 phenotype ...
Negin Pournoori, Heela Sarlus, Dick J. Sjöström, Rohith Pavan Parvathaneni, Oommen P. Varghese, Vesa P. Hytönen, Robert A. Harris, Per H. Nilsson, Oommen P. Oommen   +8 more
wiley   +1 more source

The role of the complement system in traumatic brain injury: a review [PDF]

, 2018
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of ...
A Alawieh, A Jauneau, A Kumar, Adnan Hammad, AG Therien, AH Stephan, AI Faden, AL Vescovi, B Oderfeld-Nowak, B Stevens, B-M Bellander, B-M Bellander, B-M Bellander, BJ Gabbe, BP Morgan, BP Morgan, C Cudrici, C Wang, CA Colton, CG Cochrane, D Cederberg, D Dupret, D Ricklin, D Shlosberg, DG Nicholls, DL Sewell, DN Abrous, DP Ankeny, DP Schafer, DT Fearon, E Makou, ED Ponomarev, EO Samstad, F Orsini, F Qiao, FH Brennan, G Arbore, G Winocur, GM Pasinetti, GT Manley, H Osaka, HD Manthey, HG Rus, HG Rus, HX Nguyen, I Leinhase, I Leinhase, I Leinhase, IP Karve, J Rogers, J van Beek, J van Beek, J Wetherington, JJ Ramirez, JL Cole, JR Dunkelberger, K Fluiter, K Färber, K Heese, K Järlestedt, K Pisalyaput, KA Kigerl, L Berliocchi, L Boos, L Longhi, L Longhi, L Soane, Laura Westacott, LG Coulthard, M Bénard, M Bénard, M Fosbrink, M Lévi-Strauss, M Moriyama, M Rancan, M-C Mathieu, Malik Zaben, MC Carroll, MC Carroll, MC Garrett, MD Saxe, ME Benoit, ME Medof, MJ Rutkowski, MK Liszewski, ML Pearn, MM Ruseva, N Sanai, N Shinjyo, NA Martin, O Butovsky, P Gasque, PF Stahel, PF Stahel, PF Stahel, PF Stahel, PH Yager, Q Shi, R Beschorner, R Knoth, RM Chesnut, RM Ransohoff, RS Ames, S Fumagalli, S Nataf, S Nataf, S Yang, SH Weerth, SK Ludwin, SL Kaczorowski, T Fujita, T Kossmann, TA Rupprecht, TJ Shors, U Amara, VM Holers, W Zheng, WH Kwan, X de la Rosa, X Jin, Y Chu, Y Rahpeymai, Y Xiong, YR Bogestål, Z You   +124 more
core   +1 more source

First successful protocol for desensitization to eptinezumab

Headache: The Journal of Head and Face Pain, Volume 66, Issue 2, Page 556-559, February 2026.
Abstract Background Eptinezumab is an anti‐calcitonin gene‐related peptide monoclonal antibody used for migraine prevention. During clinical trials, hypersensitivity to eptinezumab was described without a clear underlying mechanism. To determine if the reaction was immunoglobulin E–mediated, the team of Nice University Hospital (Nice, France) performed
Benoit Gerard, Hubert Praudel, Michel Lanteri‐Minet, Elise Van Obberghen, Fanny Rocher‐Moreau, Johanna Rousset, Ulysse Jacquier, Sylvie Leroy, Margot Delin   +8 more
wiley   +1 more source

Role of the complement anaphylatoxin C5a-receptor pathway in atopic dermatitis in mice

Molecular Medicine Reports, 2015
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic background. The C5a‑receptor (C5aR) pathway has been reported to be involved in AD; however, the precise pathogenesis remains to be elucidated. In the present study, the contribution of the C5aR pathway to AD in mice was investigated.
DANG, LIN, HE, LEI, WANG, YAN, XIONG, JIKUI, BAI, BINGXUE, LI, YUZHEN   +5 more
openaire   +3 more sources

Adjunctive Therapies in Periodontitis: Current Concepts and the Future

Journal of Periodontal Research, Volume 61, Issue 2, Page 138-164, February 2026.
This graphical abstract summarizes the translational pathway from preclinical research to clinical implementation of adjunctive therapies for periodontitis, highlighting key barriers, innovative therapeutic strategies, and emerging tools that aim to bridge experimental discoveries with patient care.
Rafael Scaf de Molon, Joao Paulo Steffens, Erica Dorigatti de Avila, Wim Teughels, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]

, 2015
Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO, Fineschi, Vittorio, Frati, Paola, Zaami, Simona   +3 more
core   +2 more sources

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Arieli Bernardo Portugal, Renato Augusto DaMatta, Edézio Ferreira da Cunha Júnior, João Luiz Mendes Wanderley   +3 more
wiley   +1 more source