Results 101 to 110 of about 1,239,345 (193)

Expression and induction of anaphylatoxin C5a receptors in the rat liver

, 2018
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H. L., Gotze, O.   +5 more
openaire   +1 more source

The Role of Complement Component C5a in the Pathogenesis of Diabetic Kidney Disease: A New Kid on the Block? [PDF]

Cureus
Geladari V, Paschou E, Betsikos A, Pallas D, Sabanis N.   +4 more
europepmc   +1 more source

The Complement System in the Setting of Critical Illness-A Narrative Review. [PDF]

Biomolecules
Ampelakiotou K, Nikitopoulou I, Kokkoris S, Kotanidou A, Dimopoulou I, Detsika MG.   +5 more
europepmc   +1 more source

Activation of the C3a-C3aReceptor-axis is associated with endothelial dysfunction and glycocalyx damage in ST-elevation myocardial infarction. [PDF]

Basic Res Cardiol
Vahldieck C, Löning S, Hamacher C, Fels B, Svensson T, Rudzewski B, Weil J, Kusche K.   +7 more
europepmc   +1 more source

Complement Anaphylatoxin C5a-Induced Mouse Lymphatic Functions Modulate Interactions Between Endothelial Cells and T Lymphocytes. [PDF]

Immune Netw
Rich HE, Li YD, Hok KD, Mueller-Ortiz SL, Domozhirov AY, Shadid A, Thandavarayan RA, Yalamanchili HK, Doursout MF, Weng-Mills T, Bishehsari F, Banda NK, Eckel-Mahan KL, Restrepo MI, Shivshankar P.   +14 more
europepmc   +1 more source

The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]

Immun Inflamm Dis
Sunmboye K, Millan P.
europepmc   +1 more source

Development of C5a receptor antagonists

, 1999
During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia.
Taylor, S. M., Fairlie, D., Wong, A.
core  

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a. [PDF]

PLoS Biol
Kiran A, Thomason PA, Versluis DM, Paschke PI, Donnelly H, Tweedy L, Lilla S, Bravo-Ferrer I, Shergold A, Devlin R, Roberts EW, Insall RH.   +11 more
europepmc   +1 more source

The Intracellular C5a-mtC5aR1 Axis Promotes Necroptosis in Dry Eye Through DRP1-Mediated Mitochondrial Dysfunction. [PDF]

Invest Ophthalmol Vis Sci
Wang L, Yan H, Shen Y, Xin S, Dong C, Li J, Ren Y, Chen W, Zheng Q.   +8 more
europepmc   +1 more source

Targeting C3a and C5a Signaling-A Game Changer for Cancer Therapy? [PDF]

Biology (Basel)
Hudgins H, Molina V, Wiernicki S, Okwuegbe K, Feng X, Wang H.   +5 more
europepmc   +1 more source