Results 101 to 110 of about 6,320 (210)
The complement cascade as a mediator of tissue growth and regeneration [PDF]
, 2010 Recent evidence has demonstrated that the complement cascade is involved in a variety of physiologic and pathophysiologic processes in addition to its role as an immune effector.
Martin J. Rutkowski +5 more
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Discover OncologyBackground The EGFR is abundantly expressed in prostate cancer (PC). The anaphylatoxin C5a induces leukocyte migration via the C5a receptor (C5aR) by releasing matrix metalloproteinases (MMP) to favor metastasis in the tumor microenvironment.
Ayed A. Dera, Majed Al Fayi
doaj +1 more source
Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]
, 2014 The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W. +8 more
core +1 more source
Targeting complement anaphylatoxin C5a receptor in hyperoxic lung injury in mice
Molecular Medicine Reports, 2014 Receptor binding of complement anaphylatoxin C5a results in proinflammatory activation of numerous diseases, but the role of receptor-mediated action during hyperoxic lung injury has, to the best of our knowledge, not yet been investigated. The contribution of the C5a receptor (C5aR) to hyperoxic lung injury in mice was investigated in this study.
XU, YING, TIAN, ZHE, XIE, PEIYU
openaire +3 more sources
Pathophysiological mechanisms of disease severity in COVID-19: An update
Journal of Advanced Biotechnology and Experimental TherapeuticsThe pandemic of COVID-19 has created a confounding global health crisis with more than 25 million cases and 870,000 deaths worldwide. The novel coronavirus, SARS-CoV-2, exploits the human ACE2 receptor and potential CD147 to invade a plethora of organ ...
Md. Hasanul Banna Siam +4 more
doaj +1 more source
Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice [PDF]
, 2014 There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Bowman, Andrew S. +8 more
core +2 more sources
The pathophysiology of the complement system in leprosy [PDF]
, 1991 The complement system, which consists of a group of proteins and glycoproteins, generally serves to amplify the effects of the interaction of antigen with antibody.
Ramanathan, V D
core
Modulation of human lymphocyte function by C3a and C3a(70-77). [PDF]
, 1982 Human C3a and the synthetic octapeptide C3a (70-77), which retains the activities of an anaphylatoxin, inhibit in a concentration-dependent manner the generation of leukocyte inhibitory factor (LIF) activity by human mononuclear leukocytes and T ...
Goetzl, EJ, Payan, DG, Trentham, DE
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Aquaculture NutritionCinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear.
Yixin Gu +9 more
doaj +1 more source
Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement [PDF]
, 2004 The complement system is important in immunosurveillance against tumors. However, malignant cells are usually resistant to complement-mediated lysis. In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor ...
Ajona, D. (Daniel) +8 more
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