Results 121 to 130 of about 3,648 (168)

Why Is C5a Inflammatory Complement Inhibition Not Enough to Improve C3 Glomerulopathy? [PDF]

J Am Soc Nephrol
Zipfel PF, Skerka C.
europepmc   +1 more source

Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood. [PDF]

Scand J Immunol
Cyranka L, Mariegaard I, Fageräng B, Pérez-Alós L, Harpf V, Mollnes TE, Garred P, Rosbjerg A.   +7 more
europepmc   +1 more source

Dual roles of complement in ulcerative colitis: insights from clinical studies and animal research. [PDF]

Eur J Med Res
Qin Z, Wang R, Zhang Y.
europepmc   +1 more source

Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors

Mishra S, Yadav MK, Dalal A, Ganguly M, Yadav R, Sawada K, Tiwari D, Roy N, Banerjee N, Fung JN, Marallag J, Cui CS, Li XX, Lee JD, Dsouza CA, Saha S, Sarma P, Rawat G, Zhu H, Khant HA, Clark RJ, Sano FK, Banerjee R, Woodruff TM, Nureki O, Gati C, Shukla AK.   +26 more
europepmc   +1 more source

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Expression of the anaphylatoxin C5a receptor in non-myeloid cells

Molecular Immunology, 1999
C5, a 74 amino acid peptide cleaved from the complement protein C5, represents the most potent anaphylatoxin and possesses inflammatory as well as immunomodulatory activities. In the past, expression of the receptor for the anaphylatoxin C5a (C5aR) has been thought to be restricted to cells of myeloid origin.
Jörg Zwirner, O Götze
exaly   +3 more sources

C5A Anaphylatoxin and Its Seven Transmembrane-Segment Receptor

Annual Review of Immunology, 1994
The molecular cloning of the C5a receptor places this molecule in the superfamily of G-protein coupled receptors. This superfamily is characterized by the presence of signature motifs including seven hydrophobic domains which span the cell membrane and impart a predicted serpentine topology to the receptor proteins.
C Gérard, N P Gérard
exaly   +4 more sources

The chemotactic receptor for human C5a anaphylatoxin

Nature, 1991
Host defence and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by a chemotactic factor that directs the approach of phagocytic cells. Complement receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor mediates the pro-inflammatory and ...
N P, Gerard, C, Gerard
openaire   +2 more sources

Distribution of Rat C5a Anaphylatoxin Receptor

Microbiology and Immunology, 2002
AbstractThe anaphylatoxin, complement 5a (C5a), plays a key role in mediating various inflammatory reactions following complement activation. Several investigators have reported that C5a receptor (C5aR) is expressed in non‐myeloid cells under certain conditions or in different cell lines.
Hiroyasu, Akatsu, Masayoshi, Abe, Takashi, Miwa, Hisashi, Tateyama, Seiji, Maeda, Noriko, Okada, Kiyohide, Kojima, Hidechika, Okada   +7 more
openaire   +2 more sources

Modeling Molecular Mechanisms of Binding of the Anaphylatoxin C5a to the C5a Receptor

Biochemistry, 2008
This study presents the 3D model of the complex between the anaphylatoxin C5a and its specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) complex with a peptide ligand deduced by a molecular modeling procedure analyzing various conformational possibilities of the extracellular loops and the N-terminal segment of ...
Gregory V, Nikiforovich, Garland R, Marshall, Thomas J, Baranski   +2 more
openaire   +2 more sources