Results 111 to 120 of about 6,320 (210)

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Respiratory Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced ...
Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana   +12 more
doaj   +1 more source

Proteomics of left ventricular structure in the Multi‐Ethnic Study of Atherosclerosis

ESC Heart Failure
Aims Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF).
Tess E. Peterson, Joao A.C. Lima, Sanjiv J. Shah, David A. Bluemke, Alain G. Bertoni, Yongmei Liu, Debby Ngo, Vinithra Varadarajan, Josyf C. Mychaleckyj, Craig W. Johnson, Bruce M. Psaty, Clary B. Clish, Kent D. Taylor, Peter Durda, Russell P. Tracy, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Wendy S. Post, James S. Pankow   +19 more
doaj   +1 more source

C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis [PDF]

, 2017
Adrian W. S. Ho, Alessandra Mortellaro, Baalasubramanian Sivasankar, Federica Laudisi, Gim Gee Teng, Hanif J. Khameneh, Heidi Derks, Matheswaran Kandasamy   +7 more
core   +1 more source

Does C3-deficiency alter the amyloid precursor protein expression and thalamic structure following cranial radiotherapy to the developing brain? [PDF]

, 2017
Brain tumours in children preserve certain characteristics of the original stem cells that develop during foetal life. How do cancer cells acquire these characteristics is unknown. New research suggests that cell origin and its genetic alterations play a
Amin, Safaeldin
core  

Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer’s disease [PDF]

, 2015

core   +1 more source

Expression and induction of anaphylatoxin C5a receptors in the rat liver

, 2018
The C5a-anaphylatoxin which is generated by limited proteolysis upon activation of the fifth component of complement may be induced by the classical, the alternative or the lectin pathway. C5a has been shown, under normal conditions, to induce the release of prostanoids from Kupffer cells (KC) and hepatic stellate cells (HSC) and thereby indirectly to ...
Schlaf, G., Schmitz, M., Rothermel, E., Jungermann, K., Schieferdecker, H. L., Gotze, O.   +5 more
openaire   +1 more source

The Role of Complement Component C5a in the Pathogenesis of Diabetic Kidney Disease: A New Kid on the Block? [PDF]

Cureus
Geladari V, Paschou E, Betsikos A, Pallas D, Sabanis N.   +4 more
europepmc   +1 more source

The Complement System in the Setting of Critical Illness-A Narrative Review. [PDF]

Biomolecules
Ampelakiotou K, Nikitopoulou I, Kokkoris S, Kotanidou A, Dimopoulou I, Detsika MG.   +5 more
europepmc   +1 more source

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a. [PDF]

PLoS Biol
Kiran A, Thomason PA, Versluis DM, Paschke PI, Donnelly H, Tweedy L, Lilla S, Bravo-Ferrer I, Shergold A, Devlin R, Roberts EW, Insall RH.   +11 more
europepmc   +1 more source

Potential Mechanisms of Mast Cell Activation in Human Atherosclerotic Coronary Arteries [PDF]

, 2003
Laine, Petri
core